Abstract: A method of manufacturing an intervertebral implant comprising forming the implant with at least one dimension that is greater than a desired dimension, the implant comprising a superior bone facing surface, an inferior bone facing surface, a distal side, a proximal side, and lateral sides; coating at least the superior bone facing surface and the inferior bone facing surface with an osteophilic material; and machining one or more of the distal side, proximal side and lateral sides to the desired dimensions after coating; wherein edges of the coating on the superior bone facing surface and the inferior bone facing surface are machined to be flush with the distal side, proximal side and/or lateral sides.

Abstract: A digital asset delivery network that consists of a cryptographic scheme and a decentralized network that runs on a blockchain. The decentralized network consists of a computer program that interact with the network by issuing electronic messages, computer programs that validate those messages as entries into blockchain and agree on blocks to publish next, and computer programs that run cryptographic multi-party computation protocols. The multi-party computation protocol generates public keys necessary to create cryptocurrency or crypto asset wallets, and also generates the digital signatures necessary to create a transaction for submission to the crypto asset's underlying decentralized network and blockchain.

Abstract: A stranding apparatus including a preformer attached to a preformer shaft; an adjustable core guide attached to the preformer shaft; and a ring positioned away from the preformer and centered on a longitudinal axis of the preformer shaft; wherein a gap is formed between the ring and the adjustable core guide, through which a stranding element can pass.

Abstract: Differential expression of nucleic acids in the brains of subjects suffering from late-onset depression has been demonstrated. The invention provides methods useful in the determination of late-onset depression. Also provided by the present invention is a screening method for the identification of compounds for treatment, prevention or diagnosis of late-onset depression.

Abstract: A stranding apparatus including a performer attached to a preformer shaft; an adjustable core guide attached to the preformer shaft; and a ring positioned away from the performer and centered on a longitudinal axis of the preformer shaft; wherein a gap is formed between the ring and the adjustable core guide, through which a stranding element can pass.

Abstract: Differential expression of nucleic acids in the brains of subjects suffering from late-onset depression has been demonstrated. The invention provides methods useful in the determination of late-onset depression. Also provided by the present invention is a screening method for the identification of compounds for treatment, prevention or diagnosis of late-onset depression.

Abstract: Differential expression of nucleic acids in the brains of subjects suffering from late-onset depression has been demonstrated. The invention provides methods useful in the determination of late-onset depression. Also provided by the present invention is a screening method for the identification of compounds for treatment, prevention or diagnosis of late-onset depression.

Abstract: Differential expression of nucleic acids in the brains of subjects suffering from late-onset depression has been demonstrated. The invention provides methods useful in the determination of late-onset depression. Also provided by the present invention is a screening method for the identification of compounds for treatment, prevention or diagnosis of late-onset depression.

Abstract: Described is a desiccant arrangement for a computing device. The computing device comprises a sealed housing, an optical element having at least one substantially flat surface internal to the sealed housing and a desiccant removing moisture from air within the sealed housing to prevent accumulation of the moisture on the at least one substantially flat surface.

Abstract: An apparatus and method for performing enhanced algorithmic processing, including reduced cycle-count fast Fourier transform (FFT) calculations. In one aspect, the invention comprises a user-configurable processor having an extension instruction adapted for reduced cycle-count algorithmic operations. In one exemplary embodiment, the processor is an extensible core, and the extension instruction comprises a 32-bit instruction word linked with existing circuitry in the processor core used for multiply-accumulate (mac) instructions. 16-bit, 24-bit, and dual 16-bit multiply options are available for the multiply/accumulate unit of the processor. The extension instruction is pipelined to the same number of stages as the mac instructions, thereby avoiding unnecessary stalls and increasing performance. A modified accumulator data path used in support of the foregoing instruction is also described.

Abstract: Microfluidic devices and methods for performing a microfluidic process are presented. A microfluidic device conforms with a standard well plate format. The device includes a well plate comprising a plate and an array of wells formed on or in the plate, and a microfluidic structure connecting at least two of the wells. The device can rely exclusively on gravitational and capillary forces that exist in channels within the microfluidic structure when receiving fluid streams. Also disclosed is a microfluidic device having an array of microfluidic structures, each connecting at least two wells of a well plate, and connecting three or more wells in alternative embodiments. With the present invention, a large number of microfluidic processes or reactions can be performed simultaneously.

Abstract: Microfluidic devices and methods for performing a microfluidic process are presented. A microfluidic device conforms with a standard well plate format. The device includes a well plate comprising a plate and an array of wells formed on or in the plate, and a microfluidic structure connecting at least two of the wells. The device can rely exclusively on gravitational and capillary forces that exist in channels within the microfluidic structure when receiving fluid streams. Also disclosed is a microfluidic device having an array of microfluidic structures, each connecting at least two wells of a well plate, and connecting three or more wells in alternative embodiments. With the present invention, a large number of microfluidic processes or reactions can be performed simultaneously.

Abstract: Microfluidic devices and methods for performing a microfluidic process are presented. A microfluidic device conforms with a standard well plate format. The device includes a well plate comprising a plate and an array of wells formed on or in the plate, and a microfluidic structure connecting at least two of the wells. The device can rely exclusively on gravitational and capillary forces that exist in channels within the microfluidic structure when receiving fluid streams. Also disclosed is a microfluidic device having an array of microfluidic structures, each connecting at least two wells of a well plate, and connecting three or more wells in alternative embodiments. With the present invention, a large number of microfluidic processes or reactions can be performed simultaneously.

Abstract: An apparatus and method for performing enhanced algorithmic processing, including reduced cycle-count fast Fourier transform (FFT) calculations. In one aspect, the invention comprises a user-configurable processor having an extension instruction adapted for reduced cycle-count algorithmic operations. In one exemplary embodiment, the processor is an extensible core, and the extension instruction comprises a 32-bit instruction word linked with existing circuitry in the processor core used for multiply-accumulate (mac) instructions. 16-bit, 24-bit, and dual 16-bit multiply options are available for the multiply/accumulate unit of the processor. The extension instruction is pipelined to the same number of stages as the mac instructions, thereby avoiding unnecessary stalls and increasing performance. A modified accumulator data path used in support of the foregoing instruction is also described.

Abstract: An improvement in lead-acid batteries is disclosed. The improvement is directed toward construction of a lead-acid rechargeable battery in which bipolar positive and negatives plates (biplates) share the same grid or substrate. According to the present invention, such biplates are stacked upon each other, separated by interleaved, highly porous glass mat separators. These substratea positioned between the positive and negative plate areas act as electrical connections attaching the plates to terminals of the battery. The battery case cover is used to provide compressive force on the biplates and separators.

Abstract: A lead-oxide paste mix for use as an active material superimposed upon the plates of a lead-acid rechargeable battery. Battery grades of oxides of lead are mixed with a dilute solution of hydrogen peroxide, either alone or with additives and/or expanders. The resultant paste offers such advantages as reduced curing and drying times and/or the elimination of the need for curing and drying, lower dry active material weights and improved cohesion when compared to conventional pastes manufactured from leady oxides, sulfuric acid, and water.