Abstract: Provided herein are antibodies comprising non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their production and methods of their use. The antibodies are useful for methods of treatment and prevention, methods of detection and methods of diagnosis.

Abstract: Provided herein are modified Fc proteins comprising non-natural amino acid residues at site-specific positions, conjugates of the modified Fc proteins for therapy or diagnosis, compositions comprising the modified Fc proteins and conjugates thereof, methods of their production and methods of their use. The modified Fc proteins and conjugates are useful for methods of treatment and prevention, methods of detection and methods of diagnosis.

Abstract: A rock-fracturing mining explosive element; said explosive element subjected to an initial spreading against a target surface on impact of said explosive element with said target surface; said explosive element so constructed as to control the rate of spreading and compression against said surface prior to detonation.

Abstract: A connector apparatus including a body, a fluid supply connection subassembly and a docking station connection subassembly. The body defines a fluid passageway including a first passageway portion and a second passageway portion generally perpendicular to the first passageway portion. The first passageway portion including a first end outlet and the second passageway portion including a second end outlet. The fluid supply connection subassembly is at the first end of the body and includes an elongated probe defined by the first end outlet. The docking station connection subassembly is at the second end of the body and includes an elongated spout defining the second end outlet. The elongated spout extends from a frame including an outside surface and a base rim. The base rim defines a plane with the elongated spout extending therebeyond.

Abstract: A spout assembly for a flexible bag having a base flange, a body and a dual lead thread. The base flange has a top surface and a bottom surface. At least one of the top surface and the bottom surface are configured for coupling to a flexible bag. The body extends from the base flange and includes a proximal end corresponding to the base flange and a distal end spaced apart therefrom, and, an inner surface and an outer surface. The dual lead thread extends along the outer surface of the body between the proximal end and the distal end. The dual lead thread has a first threadform and a second threadform. The first threadform has a first threadform length. The second threadform has a second threadform length. The length of the first threadform is different than that of the second threadform.

Abstract: A spout assembly for a flexible bag having a base flange, a body and a dual lead thread. The base flange has a top surface and a bottom surface. At least one of the top surface and the bottom surface are configured for coupling to a flexible bag. The body extends from the base flange and includes a proximal end corresponding to the base flange and a distal end spaced apart therefrom, and, an inner surface and an outer surface. The dual lead thread extends along the outer surface of the body between the proximal end and the distal end. The dual lead thread has a first threadform and a second threadform. The first threadform has a first threadform length. The second threadform has a second threadform length. The length of the first threadform is different than that of the second threadform.

Abstract: A tool, a tool system, and method for applying torque to a hammer union. The tool includes a handle attached to a tool head, and the tool head further includes at least two indentations, the indentations having a curved rearward wall and forming a mouth with a first width and a mid-section with a second width, wherein the mid-section width is greater than the mouth width.

Abstract: The invention describes a cleaning system in the form of a mitt having cleaning pads attached by reversible fastening means so that pads may be electively and consecutively attached, removed, or replaced. Furthermore, the invention provides a means for introducing, retaining, dispensing, and distributing a fluid, such as water or a liquid cleaning product, so that a removable pad may be irrigated with a regulated dose of fluid prior to use. The invention also describes a cooperative enclosure that can store a plurality of cleaning pads. Features of the compatible enclosure serve to physically guide the body of the mitt into alignment with a replacement pad.

Abstract: A flexible package for positionable within a vessel having an outlet with a valve dispensing member. The flexible package includes a dispensing bag and a hose spout. The dispensing bag includes a panel and a seal defining a cavity with an open top and an opening extending through the panel. The opening is spaced apart from the open top and the at least one seal. The hose spout includes an integrally molded flange and an elongated spout of a uniform material. The elongated spout extends from the molded flange and together defines an elongated channel with a proximal end and a distal end. The proximal end corresponds to the molded flange. The inner outer surface of the molded flange is coupled to the inner surface of the dispensing bag by a seal with the elongated spout extending through about the opening thereof.

Abstract: A tool, a tool system, and method for applying torque to a hammer union. The tool includes a handle attached to a tool head, and the tool head further includes at least two indentations, the indentations having a curved rearward wall and forming a mouth with a first width and a mid-section with a second width, wherein the mid-section width is greater than the mouth width.

Abstract: A tap for a flexible package having a dosing dispenser. The tap can be coupled to a spout of a flexible bag (such as the type that is provided for bag in box packaging). The tap permits the application of metered doses from the flexible bag. As the flexible bag is emptied, the flexible bag collapses, as the dosing dispenser generally prohibits the passage of air back into the flexible bag when the flowable material is emptied therefrom.

Abstract: A connector apparatus including a body, a fluid supply connection subassembly and a docking station connection subassembly. The body defines a fluid passageway including a first passageway portion and a second passageway portion generally perpendicular to the first passageway portion. The first passageway portion including a first end outlet and the second passageway portion including a second end outlet. The fluid supply connection subassembly is at the first end of the body and includes an elongated probe defined by the first end outlet. The docking station connection subassembly is at the second end of the body and includes an elongated spout defining the second end outlet. The elongated spout extends from a frame including an outside surface and a base rim. The base rim defines a plane with the elongated spout extending therebeyond.

Abstract: Systems and indicators of cleaning effectiveness are provided for deployment in an environment where samples of different vacuum cleaners are displayed for consideration by potential purchasers or renters of such vacuum cleaners to facilitate comparisons of cleaning effectiveness between or among the different vacuum cleaners.