Patents by Inventor Chris NEHME

Chris NEHME has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220243260
    Abstract: Microscopy imaging that allow for multiple mRNAs, proteins and metabolites to be spatially resolved at a subcellular level provides valuable molecular information which is a crucial factor for understanding tissue heterogeneity as for example within the tumor micro environment. The current invention describes a method (SUMI-Seq) which combines the use of Spatial Unique Molecular Identifier in situ sequencing and in vitro sequencing of rolonies derived from rolling circle amplification from padlock oligonucleotides targeting portion of RNA or cDNA transcript at a subcellular level with less limitation in the amount of transcripts and the length of the sequence that can be analyzed. Apart from padlocks oligonucleotides, the SUMI-Seq method can also be applied using circular oligonucleotides to spatially resolve proteins and metabolites to provide multiomics results.
    Type: Application
    Filed: January 31, 2022
    Publication date: August 4, 2022
    Applicant: Miltenyi Biotec B.V. & Co. KG
    Inventors: Thomas ROTHMANN, Robert PINARD, Hansueli MEYER, Andreas BOSIO, Heinrich SPIECKER, Seiyu HOSONO, Ryan HINDMAN, Emily NEIL, Chris NEHME