Abstract: The present disclosure relates to methods of treating or preventing cancer (e.g., advanced solid cancer) using Compound No. 1 or Compound No. 2: or a pharmaceutically acceptable salt thereof. The present disclosure also relates to pharmaceutical compositions and pharmaceutical kits suitable for the treatment or prevention.

Abstract: A system for delivering a replacement heart valve implant may include a handle and a valve capsule, an inner shaft extending from the handle to the capsule, an outer sheath over the inner shaft and extending from the handle to the capsule, a positioning sheath over the outer sheath and extending from the handle, a guide tube within the handle, and a distal hub attached to the positioning sheath. The distal hub may be disposed within and movable relative to the guide tube via rotation of the positioning sheath. A method of manufacturing the system may include positioning proximal and distal hubs within the guide tube, setting a first predetermined distance between proximal and distal capsule portions, moving the positioning sheath relative to the outer sheath to set a second predetermined distance between the hubs, and securing the distal hub within the guide tube at the second predetermined distance.

Abstract: Computer systems, methods, and devices for structured dynamic electronic forms are provided. The system includes a user device comprising a client form management application and a server comprising a server form management application. The client form management application generates and sends a request for a dynamic electronic form to the server. The server form management application stores the dynamic electronic form comprising separately stored form template data and form data; and merges and sends the form template data and the form data to the user device for rendering. The client form management application sends a request for a form filler package (“FFP”) comprising rules for filling out and rendering the dynamic electronic form. The server form management application sends the FFP to the user device and the client form management application renders the dynamic electronic form using the merged form template data and form data and the FFP.

Abstract: A vehicle comprising a stowage bin, an actuation assembly configured to actuate in response to an actuation signal, and a stowage bin closure operable between stored and fully deployed positions, wherein the actuation assembly is configured to deploy the stowage bin closure over an opening defined by the stowage bin.

Abstract: An apparatus includes a stowage bin defining a compartment and an airbag mounted to the stowage bin. The airbag is deployable to an inflated position. When the airbag is in the inflated position, the airbag at least partially encloses the compartment. When in the inflated position, the airbag retains items, if any, that are stored in the compartment by an occupant of the vehicle.

Abstract: An apparatus includes a stowage bin defining a compartment and an airbag mounted to the stowage bin. The airbag is deployable to an inflated position. When the airbag is in the inflated position, the airbag at least partially encloses the compartment. When in the inflated position, the airbag retains items, if any, that are stored in the compartment by an occupant of the vehicle.

Abstract: A vehicle comprising a stowage bin, an actuation assembly configured to actuate in response to an actuation signal, and a stowage bin closure operable between stored and fully deployed positions, wherein the actuation assembly is configured to deploy the stowage bin closure over an opening defined by the stowage bin.

Abstract: A digital assistant supported on devices such as smartphones, tablets, personal computers, game consoles, etc. exposes an updated and enhanced set of alarm functions to improve a device's user wake-up routines by applying automation rules to a variety of collected or sensed data and inputs in a context-aware manner in order to surface user experiences and content that are contextually meaningful and catered to the particular device user. The digital assistant can support an alarm system having network connectivity to other devices and external systems that enables the user to set an alarm and be awoken using a wide variety of stimuli such as sounds, voice, music, lights, and tactile sensations and then be given a summary of the upcoming day using verbal narration and graphical displays on the device.

Abstract: A vehicle including a storage bin and a restraint control system. An actuation assembly is configured to activate in response to a signal from the restraint control system. A tether is operable between undeployed and deployed positions and the actuation assembly is configured to deploy the tether over an opening defined by the storage bin.

Abstract: A vehicle including a storage bin and a restraint control system. An actuation assembly is configured to activate in response to a signal from the restraint control system. A tether is operable between undeployed and deployed positions and the actuation assembly is configured to deploy the tether over an opening defined by the storage bin.

Abstract: A low power, digital audio interface includes support for variable length coding depending on content of the audio data sent from the interface. A particularized coding system is implemented that uses techniques of silence detection, dynamic scaling, and periodic encoding to reduce sent data to a minimum. Other techniques include variable packet scaling based on an audio sample rate. Differential signaling techniques are also used. The digital audio interface may be used in a headphone interface to drive digital headphones. A detector in the interface may detect whether digital or analog headphones are coupled to a headphone jack and drive the headphone jack accordingly.

Abstract: A low power, digital audio interface includes support for variable length coding depending on content of the audio data sent from the interface. A particularized coding system is implemented that uses techniques of silence detection, dynamic scaling, and periodic encoding to reduce sent data to a minimum. Other techniques include variable packet scaling based on an audio sample rate. Differential signaling techniques are also used. The digital audio interface may be used in a headphone interface to drive digital headphones. A detector in the interface may detect whether digital or analog headphones are coupled to a headphone jack and drive the headphone jack accordingly.

Abstract: A low power, digital audio interface includes support for variable length coding depending on content of the audio data sent from the interface. A particularized coding system is implemented that uses techniques of silence detection, dynamic scaling, and periodic encoding to reduce sent data to a minimum. Other techniques include variable packet scaling based on an audio sample rate. Differential signaling techniques are also used. The digital audio interface may be used in a headphone interface to drive digital headphones. A detector in the interface may detect whether digital or analog headphones are coupled to a headphone jack and drive the headphone jack accordingly.

Abstract: A digital assistant supported on devices such as smartphones, tablets, personal computers, game consoles, etc. exposes an updated and enhanced set of alarm functions to improve a device's user wake-up routines by applying automation rules to a variety of collected or sensed data and inputs in a context-aware manner in order to surface user experiences and content that are contextually meaningful and catered to the particular device user. The digital assistant can support an alarm system having network connectivity to other devices and external systems that enables the user to set an alarm and be awoken using a wide variety of stimuli such as sounds, voice, music, lights, and tactile sensations and then be given a summary of the upcoming day using verbal narration and graphical displays on the device.

Abstract: An attachment assembly for securing a child safety seat to a mounting portion of a vehicle is provided. The attachment assembly may include a guide having a channel, and a metal strap positioned in the channel of the guide in a retracted configuration such that a free end of the metal strap is adjacent to a front face of the guide, a fixed end of the metal strap is secured to a side of the channel, and a body of the strap is bent along a radius so as to double back between the free end and the fixed end. When pulled in tension, the metal strap is configured to transition from the retracted configuration to an extended configuration, and the guide is configured to constrain the strap during this transition so that the strap rolls along the radius within the guide, thereby absorbing energy.

Abstract: An energy-absorbing deformable structure to attach a child seat to a mounting portion of a vehicle is provided. The energy-absorbing deformable structure comprises a loop of metal rod including a base end configured to be coupled to the mounting portion of the vehicle, a distal end configured to be coupled to a child safety seat, and a plurality of sinuous deformable portions positioned intermediate to the base end and the distal end, wherein each of the sinuous deformable portions includes an inwardly extending portion that extends inward from a perimeter of the deformable structure to a substantially central interior region of the deformable structure; wherein the sinuous deformable portions of the deformable structure are configured to be deformed when the base end and distal end are pulled in tension, thereby absorbing energy.

Abstract: An energy-absorbing deformable structure to attach a child seat to a mounting portion of a vehicle is provided. The energy-absorbing deformable structure comprises a loop of metal rod including a base end configured to be coupled to the mounting portion of the vehicle, a distal end configured to be coupled to a child safety seat, and a plurality of sinuous deformable portions positioned intermediate to the base end and the distal end, wherein each of the sinuous deformable portions includes an inwardly extending portion that extends inward from a perimeter of the deformable structure to a substantially central interior region of the deformable structure; wherein the sinuous deformable portions of the deformable structure are configured to be deformed when the base end and distal end are pulled in tension, thereby absorbing energy.

Abstract: An attachment assembly for securing a child safety seat to a mounting portion of a vehicle is provided. The attachment assembly may include a guide having a channel, and a metal strap positioned in the channel of the guide in a retracted configuration such that a free end of the metal strap is adjacent to a front face of the guide, a fixed end of the metal strap is secured to a side of the channel, and a body of the strap is bent along a radius so as to double back between the free end and the fixed end. When pulled in tension, the metal strap is configured to transition from the retracted configuration to an extended configuration, and the guide is configured to constrain the strap during this transition so that the strap rolls along the radius within the guide, thereby absorbing energy.

Abstract: A collapsible shaft having a unitary tube having an outer portion and a depressed portion dividing the outer portion into two segments. The outer portion has an outer exterior radius (Ro). The depressed portion has a depressed exterior radius (Rd). The Ro is greater than the Rd and the difference between the Ro and Rd is a depressed depth (Dd).