Abstract: The present invention relates to biodegradable perfume compositions, consumer products containing the compositions, methods of preparing the foregoing, and to methods of enhancing the performance and olfactive diversity of biodegradable perfume compositions.

Abstract: The present invention is related to a liquid dishwashing, preferably an automatic dishwashing, detergent composition comprising at least one liquid non-ionic fatty alcohol alkoxylate surfactant and at least one coloring agent; wherein the detergent composition further comprises at least one rheology modifier; wherein said rheology modifier comprises a dispersion of cellulose in a non-aqueous solvent system. The invention is further related to a dishwashing, preferably an automatic dishwashing, water-soluble container; wherein said water-soluble container is made of a thermoformed water-soluble film comprising poly(vinyl alcohol) and wherein said water-soluble container is at least partially filled with such a liquid, preferably an automatic dishwashing, detergent composition.

Abstract: There is in particular described a system (10) of conditioning sugar-containing juices or liquids (M) for the purpose of their alcoholic fermentation, comprising at least one conditioning circuit (100) capable of allowing circulation of a sugar-containing juice or liquid (M), such as fruit juices or fruit musts. The conditioning circuit (100) comprises in particular a supply duct (100.1) capable of allowing the juice or liquid (M) to be taken from a tank (C) or other storage space for the juice or liquid (M). The conditioning circuit (100) further comprises a conditioning duct (100.2) coupled with an inlet (100.2A) to the supply duct (100.1) and capable of being crossed by the juice or liquid (M). The conditioning circuit (100) further comprises an outlet duct (100.3) coupled to an outlet (100.2B) of the conditioning duct (100.2) and capable of allowing the delivery of the conditioned juice or liquid (M) by means of the conditioning duct (100.

Abstract: The present disclosure relates to systems, devices, and methods for using a first component (e.g., having a top reservoir and bottom reservoir that are fluidically connected through, and only through, a nanoporous membrane) that is able to be mated with a second component that comprises a plurality of microwells. Stimulating agents and/or candidate therapeutics may be added to the top reservoir such that cells (e.g., endothelial cells) in the top reservoir release one or more analytes that pass through the nanoporous membrane into the bottom reservoir (which may contain cells such as neurons) and into the microwells where they are captured and then detected.

Abstract: A process for the treatment of a lignocellulosic biomass comprises: a) a stage of pretreatment (2) of biomass, in order to obtain a pretreated biomass (3), b) a first stage of solid/liquid separation of all or part (3a) of the pretreated biomass (3) into a first solid fraction (7) and a first liquid fraction (6) comprising a mixture of sugars, c) a stage of enzymatic hydrolysis (14) of the first solid fraction (7) of pretreated biomass, in order to obtain a hydrolysate (15) in the form of sugar(s), d) a stage of purification (24) of said first liquid fraction by bringing said first liquid fraction (6) into contact with microorganisms consuming only the C6 sugars, in order to obtain a purified liquid fraction (26), e) a second stage e) of solid/liquid separation (27) of the purified liquid fraction (26).

Abstract: A system comprising a collocated thermal plant, water source, CO2 source and biomass growth module is disclosed. A method of improving the environment by utilizing the system is disclosed.

Abstract: The compositions, apparatuses, and methods described herein relate to the discovery that the time to detection of yeast and microorganism contaminants in microbial growth media can be improved by controlling the concentration of iron and copper.

Abstract: The present invention aims to provide a novel method for culturing muscle-derived cells. In the method, muscle-derived cells and at least one type of cells selected from the group consisting of skin-derived cells, intestine-derived cells, heart-derived cells, brain-derived cells, stomach-derived cells, embryonic membrane-derived cells, liver-derived cells, kidney-derived cells, and lung-derived cells are co-cultured. Alternatively, muscle-derived cells may be cultured in the presence of a supernatant obtained from culturing at least one type of cells selected from the group consisting of skin-derived cells, intestine-derived cells, heart-derived cells, brain-derived cells, stomach-derived cells, embryonic membrane-derived cells, liver-derived cells, kidney-derived cells, and lung-derived cells.

Abstract: The present invention relates to: a method for inhibiting aging of stem cells, comprising a step of treating stem cells with nervonic acid; and a composition for inhibiting aging of stem cells, containing nervonic acid as an active ingredient. According to the present invention, aging of aged stem cells can be restored such that high cell proliferation capacity and stem cell properties are maintained, and thus cell therapy efficacy using mesenchymal stem cells can be improved.

Abstract: The present disclosure belongs to the field of biotechnology and discloses a protein complex and production process thereof. The protein complex is obtained by stimulation of MSCs followed by lysis, and then isolation and purification. The protein complex has a strong ability to repair oxidative damage, which can reduce the size of cerebral infarction, improve neurological function, inhibit the level of neuroinflammation, and increase the number of surviving neurons.

Abstract: The present invention is related to increased accumulation of carotenoids and derivatives thereof via manipulation and heterologous expression of CarRP derived from Mucor circinelloides.

Abstract: The disclosure provides compositions and methods for preparing and using modified Taq DNA polymerases. The disclosure also provides Taq DNA polymerases having improved Sanger sequencing elongation sequencing rates as compared to commercially available Sanger sequencing reagents (i.e., AmpliTaq FS™).

Abstract: The present disclosure provides Moloney murine leukemia virus (MMLV) reverse transcriptase (RTase) variants. The present disclosure further provides amino acid positions for mutagenesis of MMLV RTase as well as nucleic acids, kits, compositions, fusion proteins, and methods including MMLV RTase variants.

Abstract: Provided is a lipase mutant in which the inhibition of activity against a dispersed substrate in the presence of a surfactant has been alleviated. The lipase mutant consists of an amino acid sequence having an identity of at least 75% with the amino acid sequence of SEQ ID NO: 2, 4, 6, or 8 and has an amino acid residue other than isoleucine at a position corresponding to position 44 numbered according to SEQ ID NO: 2.

Abstract: The invention relates to compositions and methods for targeting polynucleotides with eukaryotic RNA-guided nucleases. In particular, programmable RNA-guided DNA endonucleases termed Fanzors, can be harnessed for genome editing.

Abstract: The present disclosure discloses a kappa-carrageenase Cgk-GDSX478 for directionally preparing a kappa-carrageenan disaccharide and relates to the technical field of biological enzymes. A nucleotide sequence of a gene Cgk-GDSX478 encoding kappa carrageenase is shown in SEQ ID NO: 1, and the amino acid sequence of the encoding kappa carrageenase Cgk-GDSX478 is shown in SEQ ID NO: 2. The present disclosure also provides a method for preparing the kappa-carrageenan disaccharide: adding kappa-carrageenase Cgk-GDSX478 into a kappa-carrageenan solution, and performing enzymolysis to obtain the kappa-carrageenan disaccharide, wherein enzymolysis reaction conditions are: a temperature is 4-70° C., a pH is 3.0-11.0, and a time is 30-1440 minutes. The kappa-carrageenan disaccharide obtained by performing degradation on kappa-carrageenan by the kappa-carrageenase of the present disclosure has high singleness, which is of great significance for industrial production of the kappa-carrageenan disaccharides.

Abstract: The invention provides methods and apparatuses for extracting or separating nucleic acids from biological samples by (i) flowing an aqueous fluid containing a cell through a channel of a microfluidic device, wherein the cell gets lysed and releases, into aqueous solution in the aqueous fluid, at least one DNA molecule of at least one hundred kbp in length, (ii) capturing the DNA molecule on a capture array in the channel, and (iii) changing flow conditions of the aqueous fluid to wash the DNA from the capture array and into a collection reservoir without introducing any fragmentation enzyme or protocol, thereby maintaining the DNA molecule in constant aqueous solution from lysis of the cell to collection in reservoir, and to thus provide the DNA molecule (at least 100 kbp in length) in aqueous solution in the collection reservoir.

Abstract: Intermediate compounds (i.e., oligonucleotide fragments) are disclosed for making RNAi agents, or pharmaceutically acceptable salts thereof. In addition, methods are disclosed for making single-stranded oligonucleotides by ligating two or more of the intermediate compounds herein via a hybrid chemical-enzymatic route.

Abstract: The present invention relates to UNC13A cryptic exon antisense oligonucleotides (ASOs), pharmaceutical compositions containing them, and methods for treating, inhibiting, suppressing, and preventing neurological diseases with them.

Abstract: The present disclosure provides compositions with a modulating gene expression and methods for modulating transcription