Patents by Inventor Chris P. Miller

Chris P. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12329746
    Abstract: A method for treating AR+ breast cancer in a subject comprising administering to the subject an AR agonist (e.g., SARMs such as RAD140), or in combination with one or more therapeutic agents selected from the group consisting of cdk4/6 inhibitors, m-TOR inhibitors, PI3k inhibitors, PARP inhibitors, BCL-2 inhibitors, and MCL-1 inhibitors.
    Type: Grant
    Filed: September 29, 2023
    Date of Patent: June 17, 2025
    Assignee: Ellipses Pharma Ltd
    Inventors: Gary Hattersley, Jamal Saeh, Ziyang Yu, Chris P. Miller, Teeru Bihani
  • Publication number: 20240207234
    Abstract: A method for treating AR+ breast cancer in a subject comprising administering to the subject an AR agonist (e.g., SARMs such as RAD140), or in combination with one or more therapeutic agents selected from the group consisting of cdk4/6 inhibitors, m-TOR inhibitors, PI3k inhibitors, PARP inhibitors, BCL-2 inhibitors, and MCL-1 inhibitors.
    Type: Application
    Filed: September 29, 2023
    Publication date: June 27, 2024
    Inventors: Gary Hattersley, Jamal Saeh, Ziyang Yu, Chris P. Miller, Teeru Bihani
  • Publication number: 20230339964
    Abstract: Novel bromodomain and extraterminal domain (BET) inhibitors and to therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.
    Type: Application
    Filed: January 9, 2023
    Publication date: October 26, 2023
    Inventors: Son Minh PHAM, Sarvajit Chakravarty, Jayakanth Kankanaka, Jiyun Chen, Chris P. Miller, Jeremy D. Pettigrew, Anjan Kumar Nayak, Anup Barde
  • Publication number: 20230174545
    Abstract: Novel bromodomain and extraterminal domain (BET) inhibitors and to therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.
    Type: Application
    Filed: April 28, 2021
    Publication date: June 8, 2023
    Inventors: Son Minh PHAM, Jayakanth KANKANALA, Chris P. MILLER, Jeremy D. PETTIGREW
  • Patent number: 11584756
    Abstract: Novel bromodomain and extraterminal domain (BET) inhibitors and to therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: February 21, 2023
    Assignee: NUVATION BIO INC.
    Inventors: Son Minh Pham, Sarvajit Chakravarty, Jayakanth Kankanala, Jiyun Chen, Chris P. Miller, Jeremy D. Pettigrew, Anjan Kumar Nayak, Anup Barde
  • Publication number: 20230000876
    Abstract: The present disclosure relates to methods of treating cancers, including metastasized cancers by administering a potent CDK 2/4/6 inhibitor of the formula (I), or a pharmaceutically acceptable salt thereof, to a patient in need thereof.
    Type: Application
    Filed: June 8, 2022
    Publication date: January 5, 2023
    Inventors: Teeru BIHANI, Gary HATTERSLEY, Chris P. MILLER, Hitisha PATEL, Sergey YURASOV, Yan ZHANG
  • Publication number: 20220281875
    Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Application
    Filed: July 21, 2020
    Publication date: September 8, 2022
    Inventor: Chris P. MILLER
  • Publication number: 20220273659
    Abstract: Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.
    Type: Application
    Filed: July 1, 2020
    Publication date: September 1, 2022
    Inventors: Son Minh PHAM, Sarvajit CHAKRAVARTY, Jayakanth KANKANALA, Brahmam PUJALA, Amit SHETE, Mukesh GANGAR, Bhawana BHATT, Chris P. MILLER, Jeremy D. PETTIGREW
  • Publication number: 20210002293
    Abstract: Novel bromodomain and extraterminal domain (BET) inhibitors and to therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.
    Type: Application
    Filed: July 1, 2020
    Publication date: January 7, 2021
    Inventors: Son Minh PHAM, Sarvajit CHAKRAVARTY, Jayakanth KANKANALA, Jiyun CHEN, Chris P. MILLER, Jeremy D. PETTIGREW, Anjan Kumar NAYAK, Anup BARDE
  • Patent number: 9920044
    Abstract: This invention provides compounds of formula I, pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds and intermediates useful in the preparation of same.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: March 20, 2018
    Assignee: RADIUS PHARMACEUTICALS, INC.
    Inventor: Chris P. Miller
  • Publication number: 20170121285
    Abstract: This invention provides compounds of Formula (II), or (IIa) and or salts thereof, pharmaceutical compositions comprising a compound of Formula (II), or (IIa) and a pharmaceutically acceptable excipient, processes for making compounds for Formula (II), or (IIa) and intermediates useful in the preparation of same; and methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type II diabetes related disorders or diseases, anemia, depression, and renal disease) using compounds of Formula (I), (II), or (IIa).
    Type: Application
    Filed: November 7, 2016
    Publication date: May 4, 2017
    Inventor: Chris P. Miller
  • Publication number: 20150322059
    Abstract: This invention provides compounds of formula I, pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds and intermediates useful in the preparation of same.
    Type: Application
    Filed: July 22, 2015
    Publication date: November 12, 2015
    Inventor: Chris P. MILLER
  • Publication number: 20150266821
    Abstract: This invention provides compounds of Formula (II), or (IIa) and or salts thereof, pharmaceutical compositions comprising a compound of Formula (II), or (IIa) and a pharmaceutically acceptable excipient, processes for making compounds of Formula (II), or (IIa) and intermediates useful in the preparation of same; and methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type II diabetes related disorders or diseases, anemia, depression, and renal disease) using compounds of Formula (I), (II) or (IIa).
    Type: Application
    Filed: March 23, 2015
    Publication date: September 24, 2015
    Inventor: Chris P. MILLER
  • Patent number: 9133182
    Abstract: This invention provides compounds of formula I, pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds and intermediates useful in the preparation of same.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: September 15, 2015
    Assignee: Radius Health, Inc.
    Inventor: Chris P. Miller
  • Patent number: 8987319
    Abstract: This invention provides compounds of Formula (I), (Ia), (Ib), (Ic), (II), (IIa) or (III) and or salts thereof, pharmaceutical compositions comprising a compound of Formula (I), (Ia), (Ib), (Ic), (II), (IIa) or (III) and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type II diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds of Formula (I), (Ia), (Ib), (Ic), (II), (IIa) or (III) and intermediates useful in the preparation of same.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: March 24, 2015
    Assignee: Radius Health, Inc.
    Inventor: Chris P. Miller
  • Patent number: 8642632
    Abstract: This invention provides compounds as described herein or pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound as described herein or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor using the compounds or compositions described herein, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) using the compounds and compositions described herein and processes for making compounds described herein and intermediates useful in the preparation of same.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: February 4, 2014
    Assignee: Radius Health, Inc.
    Inventor: Chris P. Miller
  • Patent number: 8629167
    Abstract: This invention provides compounds of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig or salts thereof, pharmaceutical compositions comprising a compound of formulas I, Ia, Ib, Ic, Id, If or Ig and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig and intermediates useful in the preparation of same.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: January 14, 2014
    Assignee: Radius Health, Inc.
    Inventor: Chris P. Miller
  • Publication number: 20130217732
    Abstract: This invention provides compounds of formula I, pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds and intermediates useful in the preparation of same.
    Type: Application
    Filed: September 27, 2011
    Publication date: August 22, 2013
    Inventor: Chris P. Miller
  • Patent number: 8455525
    Abstract: This invention provides compounds of formulas I, Ia, Ib, Ic, Id, Ie, and or salts thereof, pharmaceutical compositions comprising a compound of formulas I, Ia, Ib, Ic, Id, Ie, and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds of formulas I, Ia, Ib, Ic, Id, Ie, and intermediates useful in the preparation of same.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: June 4, 2013
    Assignee: Radius Health, Inc.
    Inventor: Chris P. Miller
  • Publication number: 20130116288
    Abstract: This invention provides compounds of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig or salts thereof, pharmaceutical compositions comprising a compound of formulas I, Ia, Ib, Ic, Id, If or Ig and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig and intermediates useful in the preparation of same.
    Type: Application
    Filed: August 9, 2012
    Publication date: May 9, 2013
    Applicant: Radius Health, Inc.
    Inventor: Chris P. Miller