Patents by Inventor Chris Pappas

Chris Pappas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230248192
    Abstract: A robotic cleaner may include a body having a top wall, a bottom wall, and a sidewall extending between the top wall and the bottom wall, a suction motor, and at least one air jet assembly configured to encourage generation of a vortex between the body, a surface to be cleaned, and a vertical surface extending from the surface to be cleaned.
    Type: Application
    Filed: April 12, 2023
    Publication date: August 10, 2023
    Inventors: Andre D. BROWN, Scott TEUSCHER, John LEWIS, Chris PAPPAS, Derek A. LESSARD
  • Publication number: 20230126586
    Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function may include determining the patient's acute-on-chronic liver failure (ACLF) grade and baseline serum creatinine level; obtaining a baseline oxygenation saturation (SpO2) of the patient; administering a dose of terlipressin acetate to the patient by intravenous (IV) injection; and monitoring the patient's oxygenation saturation with pulse oximetry.
    Type: Application
    Filed: October 28, 2022
    Publication date: April 27, 2023
    Inventors: Khurram Jamil, Stephen Chris Pappas, Peter Teuber
  • Publication number: 20230108970
    Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function may include determining the patient's acute-on-chronic liver failure (ACLF) grade and baseline serum creatinine level; obtaining a baseline oxygenation saturation (SpO2) of the patient; administering a dose of terlipressin acetate to the patient by intravenous (IV) injection; and monitoring the patient's oxygenation saturation with pulse oximetry.
    Type: Application
    Filed: October 28, 2022
    Publication date: April 6, 2023
    Inventors: Khurram Jamil, Stephen Chris Pappas, Peter Teuber
  • Publication number: 20230054888
    Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of improving kidney function in an adult patient with hepatorenal syndrome with rapid reduction in kidney function may include determining the patient’s acute-on-chronic liver failure (ACLF) grade and baseline serum creatinine level; obtaining a baseline oxygenation saturation (SpO2) of the patient; administering a dose of terlipressin acetate to the patient by intravenous (IV) injection; and monitoring the patient’s oxygenation saturation with pulse oximetry.
    Type: Application
    Filed: October 28, 2022
    Publication date: February 23, 2023
    Inventors: Khurram Jamil, Stephen Chris Pappas, Peter Teuber
  • Publication number: 20220143132
    Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A patient identified as suffering from HRS-1 is tested to determine if the patient meets at least two out of three criteria, wherein the three criteria include a WBC<4 or >12 cells/4; HR>90 bpm; and any one of HCO3<21 mmol/L or PaCO2<32 mmHg or >20 breaths per minute. If the patient meets at least two of the criteria, he or she is administered terlipressin in an amount effective to produce a reduction in serum creatinine of at least 1.0 mg/dL.
    Type: Application
    Filed: January 28, 2022
    Publication date: May 12, 2022
    Inventors: Khurram Jamil, Stephen Chris Pappas, Jim Potenziano
  • Publication number: 20210290725
    Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of treating an adult patient with type 1 hepatorenal syndrome (HRS-1) may include administering a dose of terlipressin to the patient if the patient has a baseline model end stage liver disease (MELD) score <35, the patient has a serum creatinine (SCr) <5 mg/dl, the patient has an ACLF Grade <3, or a combination thereof and/or monitoring the patient's oxygenation level (SpO2) before and during treatment with the terlipressin.
    Type: Application
    Filed: June 7, 2021
    Publication date: September 23, 2021
    Inventors: Khurram Jamil, Stephen Chris Pappas, Peter Teuber
  • Publication number: 20210128676
    Abstract: The principles and embodiments of the present disclosure relate to methods of increasing survival of a patient having type 1 hepatorenal syndrome (HRS-1) and low mean arterial pressure (MAP). The methods may include identifying a patient having HRS-1 that has a baseline MAP of less than 65 mmHg, and administering, to the patient, an amount of terlipressin effective to treat the HRS-1 in the patient. In other aspects, the method may include administering an effective dose of terlipressin to a patient in need thereof every 6 hours by intravenous (IV) bolus injection over 2 minutes, where the dose is sufficient to yield an increase in MAP and decrease in heart rate in the patient. The patient may not have overt sepsis, septic shock, or uncontrolled infection.
    Type: Application
    Filed: October 29, 2020
    Publication date: May 6, 2021
    Inventors: Khurram Jamil, Stephen Chris Pappas, Peter Teuber
  • Publication number: 20200246418
    Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A patient identified as suffering from HRS-1 is tested to determine if the patient meets at least two out of three criteria, wherein the three criteria include a WBC<4 or >12 cells/4; HR>90 bpm; and any one of HCO3<21 mmol/L or PaCO2<32 mmHg or >20 breaths per minute. If the patient meets at least two of the criteria, he or she is administered terlipressin in an amount effective to produce a reduction in serum creatinine of at least 1.0 mg/dL.
    Type: Application
    Filed: March 24, 2020
    Publication date: August 6, 2020
    Inventors: Khurram Jamil, Stephen Chris Pappas, Jim Potenziano
  • Publication number: 20200237856
    Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A method of treating an adult patient with type 1 hepatorenal syndrome (HRS-1) may include assessing a baseline serum creatinine level prior to administration of terlipressin to the patient, initiating dosing of about 0.5 mg to about 1 mg of terlipressin to the patient every 6 hours by IV for 1-3 days, assessing a serum creatinine level in the patient at day 4±1 day from initiating dosing, administering a modified dosage of terlipressin based on a comparison of the assessed serum creatinine level at day 4±1 day and the baseline serum creatinine level, and continuing administration until 24 hours after two consecutive serum creatinine levels of ?1.5 mg/dL at least 2 hours apart for a maximum of 14 days. The treatment may result in verified reversal of the HRS-1.
    Type: Application
    Filed: March 24, 2020
    Publication date: July 30, 2020
    Inventors: Khurram Jamil, Stephen Chris Pappas, Jim Potenziano
  • Publication number: 20200046798
    Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A patient identified as suffering from HRS-1 is tested to determine if the patient meets at least two out of three criteria, wherein the three criteria include a WBC<4 or >12 cells/4; HR>90 bpm; and any one of HCO3<21 mmol/L or PaCO2<32 mmHg or >20 breaths per minute. If the patient meets at least two of the criteria, he or she is administered terlipressin in an amount effective to produce a reduction in serum creatinine of at least 1.0 mg/dL.
    Type: Application
    Filed: October 30, 2019
    Publication date: February 13, 2020
    Inventors: Khurram Jamil, Stephen Chris Pappas, Jim Potenziano
  • Publication number: 20190328831
    Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A patient identified as suffering from HRS-1 is tested to determine if the patient meets at least two out of three criteria, wherein the three criteria include a WBC<4 or >12 cells/4; HR>90 bpm; and any one of HCO3<21 mmol/L or PaCO2<32 mmHg or >20 breaths per minute. If the patient meets at least two of the criteria, he or she is administered terlipressin in an amount effective to produce a reduction in serum creatinine of at least 1.0 mg/dL.
    Type: Application
    Filed: May 14, 2019
    Publication date: October 31, 2019
    Inventors: Khurram Jamil, Stephen Chris Pappas, Jim Potenziano
  • Patent number: 10335452
    Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A patient identified as suffering from HRS-1 is tested to determine if the patient meets at least two out of three criteria, wherein the three criteria include a WBC<4 or >12 cells/?L; HR>90 bpm; and any one of HCO3<21 mmol/L or PaCO2<32 mmHg or >20 breaths per minute. If the patient meets at least two of the criteria, he or she is administered terlipressin in an amount effective to produce a reduction in serum creatinine of at least 1.0 mg/dL.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: July 2, 2019
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Khurram Jamil, Stephen Chris Pappas, Jim Potenziano
  • Publication number: 20160113994
    Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A patient identified as suffering from HRS-1 is tested to determine if the patient meets at least two out of three criteria, wherein the three criteria include a WBC<4 or >12 cells/4; HR>90 bpm; and any one of HCO3<21 mmol/L or PaCO2<32 mmHg or >20 breaths per minute. If the patient meets at least two of the criteria, he or she is administered terlipressin in an amount effective to produce a reduction in serum creatinine of at least 1.0 mg/dL.
    Type: Application
    Filed: October 22, 2015
    Publication date: April 28, 2016
    Applicant: Ikaria Therapeutics LLC
    Inventors: Khurram Jamil, Stephen Chris Pappas, Jim Potenziano
  • Publication number: 20100113530
    Abstract: Methods and compositions for treating, managing, and/or preventing cerebral malaria are disclosed.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 6, 2010
    Inventors: Philip Manton Brown, Constance Ann Marjory Finney, Kevin Charles Kain, Tamas Oravecz, Stephen Chris Pappas
  • Patent number: 5534281
    Abstract: The present invention provides apparatus and a method for making printed foods such as cookies, crackers, and snacks at high production speeds on a continuous basis. The apparatus includes a rotary printer which is synchronized with dough forming apparatus such as a rotary cutter or rotary molder.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: July 9, 1996
    Assignee: Nabisco, Inc.
    Inventors: Chris Pappas, Daniel A. Koppa, Roger E. Skeels, Agostino Aquino
  • Patent number: 5340598
    Abstract: Spherical baked goods, such as, cookies, crackers and snacks, are produced on a mass production basis by feeding a farinaceous dough or other food composition to one or a plurality of dies which shape it into ropes. The shaped extrudate ropes obtained from each die are cut by a cutting means, such as, a reciprocating cutter, which severs and shapes the rope into substantially spherical, cylindrical or rounded pieces. The doughs which are cut into substantially spherical, cylindrical or rounded pieces can be raw, partially cooked or baked, or fully cooked. A spherical or rounded shape is maintained or obtained upon subsequent baking or leavening of the substantially spherical dough pieces by continuously moving them relative to the oven conveyer so as to avoid flattening of the dough piece due to spreading. The baked pieces are sufficiently rounded or spherical so as to permit continuous application of confectionery coatings of substantially uniform thickness by pan coating techniques.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: August 23, 1994
    Assignee: Nabisco, Inc.
    Inventors: Richard C. Hay, Jr., Chris Pappas, Harry J. Bergstrom, Richard D. Fazzolare
  • Patent number: 5162119
    Abstract: The present invention provides apparatus for making printed foods such as cookies, crackers, and snacks at high production speeds on a continuous basis. The apparatus includes a rotary printer which is synchronized with dough forming apparatus such as a rotary cutter or rotary molder.
    Type: Grant
    Filed: April 9, 1991
    Date of Patent: November 10, 1992
    Assignee: Nabisco, Inc.
    Inventors: Chris Pappas, Daniel A. Koppa, Roger E. Skeels, Agostino Aquino