Abstract: Provided are modified isolated ADAM10 modulating peptides and methods of using the same to modulate ADAM10 biological activities, inhibit ADAM10 biological activities associated with diseases, disorders, or conditions in subjects, including but not limited to decreasing inflammation and inhibiting undesirablecell proliferation. In some embodiments, the modified isolated ADAM10 modulating peptides are based on SEQ ID NO: 3 or SEQ ID NO: 4, and in some embodiments include modifications at or near the N-terminal and/or the C-terminal ends of the disclosed peptides as well as substitutions, insertions, and deletions at one or more amino acid positions of the ADAM10 prodomain peptides disclosed herein.

Abstract: Provided are ADAM9 modulating peptides and methods for using the same to modulate ADAM9 biological activities in vitro and/or in vivo, to inhibit ADAM9 biological activities associated with diseases or disorders in subjects, to decrease inflammation, and to inhibit undesirable cellular proliferation, fibrosis, and angiogenesis. In some embodiments, the ADAM9 modulating peptides include modifications of one or more amino acids of the human ADAM9 prodomain amino acid sequence, and in some embodiments the ADAM9 modulating peptides include other modifications such as but not limited to the addition of PEG groups.

Abstract: Provided are modified isolated ADAM10 modulating peptides and methods of using the same to modulate ADAM10 biological activities, inhibit ADAM10 biological activities associated with diseases, disorders, or conditions in subjects, including but not limited to decreasing inflammation and inhibiting undesirable cell proliferation. In some embodiments, the modified isolated ADAM10 modulating peptides are based on SEQ ID NO: 3 or SEQ ID NO: 4, and in some embodiments include modifications at or near the N-terminal and/or the C-terminal ends of the disclosed peptides as well as substitutions, insertions, and deletions at one or more amino acid positions of the ADAM10 prodomain peptides disclosed herein.

Abstract: A process, device and system for mapping usage data from a plurality of utility usage nodes, such as electricity usage meters, to one or more utility distribution nodes, such as a transformer, in which utility usage data collected at a collection device from the plurality of utility usage nodes at predetermined intervals is received, and utility distribution data collected at the collection device from the utility distribution node at the predetermined intervals is likewise received. Aggregate usage data from one or more of the plurality of utility usage nodes is compared to distribution data from the utility distribution node during one or more of the same predetermined intervals to determine, using a computer, which of the plurality of utility usage nodes is connected to the utility distribution node.

Abstract: A process, device and system for mapping usage data from a plurality of utility usage nodes, such as electricity usage meters, to one or more utility distribution nodes, such as a transformer, in which utility usage data collected at a collection device from the plurality of utility usage nodes at predetermined intervals is received, and utility distribution data collected at the collection device from the utility distribution node at the predetermined intervals is likewise received. Aggregate usage data from one or more of the plurality of utility usage nodes is compared to distribution data from the utility distribution node during one or more of the same predetermined intervals to determine, using a computer, which of the plurality of utility usage nodes is connected to the utility distribution node.

Abstract: A process, device and system for mapping usage data from a plurality of utility usage nodes, such as electricity usage meters, to one or more utility distribution nodes, such as a transformer, in which utility usage data collected at a collection device from the plurality of utility usage nodes at predetermined intervals is received, and utility distribution data collected at the collection device from the utility distribution node at the predetermined intervals is likewise received.