Patents by Inventor Chris R. Rasmussen

Chris R. Rasmussen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-[(thien-2-yl)methyl]-imidazole analgesics
    Patent number: 5621113
    Abstract: The 4-[(thien-2-yl)methyl]-imidazoles of the formulae: ##STR1## wherein R is hydrogen or methyl,X is hydrogen, C.sub.1-4 alkyl, bromine or chlorine, andY is hydrogen, C.sub.1-4 alkyl, bromine or chlorine;with the proviso that X and Y are not both simultaneously hydrogen.have exceptional analgesic activity.
    Type: Grant
    Filed: March 28, 1996
    Date of Patent: April 15, 1997
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Robert E. Boyd, Chris R. Rasmussen, Jeffrey B. Press
  • Guanidine derivatives
    Patent number: 5294708
    Abstract: This invention relates to new heterocyclic derivatives of guanidine and more particularly to such derivatives which have hypoglycemic activity, their methods of use for treating hyperglycemia and novel intermediate compounds for their preparation.
    Type: Grant
    Filed: July 20, 1993
    Date of Patent: March 15, 1994
    Assignee: McNeilab, Inc.
    Inventors: Henry J. Breslin, Michael J. Kukla, Chris R. Rasmussen, Robert W. Tuman
  • Guanidine derivatives, compositions and use
    Patent number: 5268373
    Abstract: This invention relates to new heterocyclic derivatives of guanidine and more particularly to such derivatives which have hypoglycemic activity, their methods of use for treating hyperglycemia and novel intermediate compounds for their preparation.
    Type: Grant
    Filed: July 28, 1992
    Date of Patent: December 7, 1993
    Assignee: McNeilab, Inc.
    Inventors: Henry J. Breslin, Michael J. Kukla, Chris R. Rasmussen, Robert W. Tuman
  • Antipsychotic hexahydro-2H-indeno[1,2-c]pyridine derivatives
    Patent number: 5075315
    Abstract: Novel hexahydro-2H-indeno[1,2-c]pyridines and their pharmaceutically acceptable acid addition salts having useful antipsychotic properties.
    Type: Grant
    Filed: May 17, 1990
    Date of Patent: December 24, 1991
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • Anxiolytic 4,5-dihydro-4-oxo-1H-imidazol-2-yl urea derivatives
    Patent number: 4657922
    Abstract: Ureas of the formula (I): ##STR1## where R.sup.1 =alkoxy or alkylthio; R.sup.2 =alkyl; and Ar=substituted or unsubstituted phenyl, useful as anxiolytic agents as well as intermediates useful in the synthesis.
    Type: Grant
    Filed: May 24, 1985
    Date of Patent: April 14, 1987
    Assignee: McNeilab, Inc.
    Inventors: Chris R. Rasmussen, Frank J. Villani, Jr.
  • Anticonvulsant N-aryl-N'-(2-thiazolidinylidene)ureas
    Patent number: 4542144
    Abstract: N-aryl-N'-(2-thiazolidinylidene)urea compounds of Formula II ##STR1## wherein: R is CH.sub.3, C.sub.2 H.sub.5, or H;R.sub.1 is CH.sub.3, C.sub.2 H.sub.5, Cl, Br, F, CF.sub.3, OCH.sub.3 or H, provided that R.sub.1 is not H where R is H;R.sub.2 is CH.sub.3 or H, provided that R.sub.2 is not H when R is H;R.sub.3 is H or F or CH.sub.3 ;R.sub.4 is H or CH.sub.3 ;R.sub.5 is CH.sub.3, C.sub.2 H.sub.5, Cl, Br, F, CF.sub.3, OCH.sub.3, have anticonvulsant activity and are useful in the treatment of epilepsy.
    Type: Grant
    Filed: September 19, 1983
    Date of Patent: September 17, 1985
    Assignee: McNeilab Inc.
    Inventor: Chris R. Rasmussen
  • N-aryl-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)ureas for intestinal disorders
    Patent number: 4466966
    Abstract: N-(substituted phenyl)-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)ureas and pharmaceutically-acceptable salts thereof are disclosed to be useful in relieving the symptoms associated with irritable bowel syndrome, and as anti-diarrheal agents.
    Type: Grant
    Filed: June 16, 1980
    Date of Patent: August 21, 1984
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • Heterocyclic derivatives of guanidine
    Patent number: 4414211
    Abstract: 5-Membered, 6-membered and 7-membered heterocyclic derivatives of guanidine having hypoglycemic activity.
    Type: Grant
    Filed: March 14, 1980
    Date of Patent: November 8, 1983
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • N-Aryl-N'-(3-methyl or ethyl-4-oxothiazolidinylidene)ureas useful for the treatment of epilepsy
    Patent number: 4402964
    Abstract: N-aryl-N'-(3-methyl or ethyl-4-oxothiazolidinylidene)urea compounds of Formula I ##STR1## wherein: R is CH.sub.3, C.sub.2 H.sub.5 ;R.sub.1 is chosen from F, Cl, Br, CH.sub.3, C.sub.2 H.sub.5, OCH.sub.3 and CF.sub.3 ;R.sub.2 is H or CH.sub.3 ;R.sub.3 is H or F;R.sub.4 is chosen from F, Cl, Br, CH.sub.3, C.sub.2 H.sub.5, OCH.sub.3 and CF.sub.3 ;have anticonvulsant activity and are useful in the treatment of epilepsy.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: September 6, 1983
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • N-Aryl-N-(4,5,6,7-tetrahydro-1H-1,3, diazepin-2-yl)ureas as antihypertensives
    Patent number: 4379786
    Abstract: N-(Substituted phenyl)-N'-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl)ureas, and pharmaceutically-acceptable salts thereof, are disclosed, as are compositions containing said ureas in a pharmaceutically-acceptable carrier, to have antihypertensive activity and to be useful in a method of reducing arterial pressure in hypertensive subjects.
    Type: Grant
    Filed: September 28, 1981
    Date of Patent: April 12, 1983
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • (1-Methyl-2-quinolinylidene) derivatives of guanidine
    Patent number: 4345083
    Abstract: (1-Methyl-2-pyridinylidene) and (1-methyl-2-quinolinylidene) derivatives of guanidine having hypoglycemic activity.
    Type: Grant
    Filed: December 10, 1979
    Date of Patent: August 17, 1982
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • N-(Substituted phenyl)-N'-(2-imidazolidinylidene)ureas
    Patent number: 4298746
    Abstract: N-(Mono- and (di-substituted phenyl)-N'-(2-imidazolidinylidene)urea compounds and acid addition salts thereof are taught, which are useful as antihypertensive agents.
    Type: Grant
    Filed: June 6, 1980
    Date of Patent: November 3, 1981
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • N-Aryl-N'-(1,4,5,6-tetrahydropyrimidine-2-yl)ureas as antihypertensives
    Patent number: 4285948
    Abstract: A process for controlling hypertension employing N-(substituted-phenyl)-N'-(1,4,5,6-tetrahydroprimidin-2-yl)ureas, and pharmaceutical compositions containing said ureas is described.
    Type: Grant
    Filed: June 16, 1980
    Date of Patent: August 25, 1981
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • (1-Methyl-2-pyridinylidene) derivatives of guanidine
    Patent number: 4266062
    Abstract: (1-Methyl-2-pyridinylidene) and (1-methyl-2-quinolinylidene) derivatives of guanidine having hypoglycemic activity.
    Type: Grant
    Filed: September 18, 1978
    Date of Patent: May 5, 1981
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • Substituted N-iminomethylpiperidines
    Patent number: 4251655
    Abstract: Substituted N-iminomethylpiperidines are disclosed which are useful for the inhibition of gastric acid secretion.
    Type: Grant
    Filed: September 20, 1979
    Date of Patent: February 17, 1981
    Assignee: McNeilab, Inc.
    Inventors: Malcolm K. Scott, Chris R. Rasmussen
  • 2-Benzhydrylimino-1,3-diazacarbocyclic compounds as inhibitors of gastric secretion
    Patent number: 4243667
    Abstract: Novel 2-benzhydrylimino-1,3-diazacarbocyclic compounds of the formula ##STR1## wherein R' and R" independently are selected from the group consisting of hydrogen and methyl, X and Y independently are selected from the group consisting of hydrogen, lower alkoxy, lower alkyl and halo, and n is an integer of from 2 to 4, inclusive; and their acid addition salts are disclosed. Compounds have antisecretory properties. Certain of the compounds also have hypoglycemic properties.
    Type: Grant
    Filed: January 30, 1979
    Date of Patent: January 6, 1981
    Assignee: McNeil Laboratories, Incorporated
    Inventor: Chris R. Rasmussen
  • Method for relieving irritable bowel syndrome symptoms
    Patent number: 4239768
    Abstract: A method for alleviating functional intestinal disorders and for treating the discomfort associated therewith and compositions therefor.
    Type: Grant
    Filed: December 22, 1978
    Date of Patent: December 16, 1980
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • 2-Benzhydrylimino-1,3-diazacarbocyclic compounds, compositions and methods of use
    Patent number: 4235894
    Abstract: Novel 2-benzhydrylimino-1,3-diazacarbocyclic compounds of the formula ##STR1## wherein R' and R" independently are selected from the group consisting of hydrogen and methyl, X and Y independently are selected from the group consisting of hydrogen, lower alkoxy, lower alkyl and halo, and n is an integer of from 2 to 4, inclusive; and their acid addition salts are disclosed. Compounds have antisecretory properties. Certain of the compounds also have hypoglycemic properties.
    Type: Grant
    Filed: January 30, 1979
    Date of Patent: November 25, 1980
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • Method for controlling hypertension and compositions
    Patent number: 4229462
    Abstract: A method for controlling hypertension by administering to hypertensive subjects a N-aryl-N'-(2-imidazolidinylidene)urea compound and compositions suitable therefor are described.
    Type: Grant
    Filed: December 22, 1978
    Date of Patent: October 21, 1980
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • Nitrogen heterocyclic carboximidamide compounds
    Patent number: 4211867
    Abstract: 5-, 6- or 7-Membered fully saturated 1-azacarbocyclic-2-ylidene derivatives of guanidine having anti-secretory and hypoglycemic activities, and further useful for treatment of cardiovascular disease states.
    Type: Grant
    Filed: August 29, 1977
    Date of Patent: July 8, 1980
    Assignee: McNeil Laboratories, Incorporated
    Inventor: Chris R. Rasmussen