Abstract: Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed. Also disclosed are methods of treating diseases and disorders using the aqueous pharmaceutical formulations disclosed herein.

Abstract: Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed. Also disclosed are methods of treating diseases and disorders using the aqueous pharmaceutical formulations disclosed herein.

Abstract: Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed. Also disclosed are methods of treating diseases and disorders using the aqueous pharmaceutical formulations disclosed herein.

Abstract: A latch assembly includes a chassis, a latch bolt moveably mounted on the chassis and having a closed position for retaining a striker and an open position for releasing the striker, a pawl having an engaged position at which the pawl is engaged with the latch bolt to hold the latch bolt in the closed position and a disengaged position at which the pawl is disengaged from the latch bolt, thereby allowing the latch bolt to move to the open position, an eccentric arrangement defining an eccentric axis and a pawl axis remote from the eccentric axis. The eccentric arrangement is rotatable about the eccentric axis, and the pawl is rotatable about the pawl axis. When the pawl moves from the engaged position to the disengaged position, the eccentric arrangement rotates in one of a clockwise and a counter-clockwise direction about the eccentric axis.

Abstract: A latch assembly includes a chassis, a latch bolt moveably mounted on the chassis and having a closed position for retaining a striker and an open position for releasing the striker, a pawl having an engaged position at which the pawl is engaged with the latch bolt to hold the latch bolt in the closed position and a disengaged position at which the pawl is disengaged from the latch bolt, thereby allowing the latch bolt to move to the open position, an eccentric arrangement defining an eccentric axis and a pawl axis remote from the eccentric axis. The eccentric arrangement is rotatable about the eccentric axis, and the pawl is rotatable about the pawl axis. When the pawl moves from the engaged position to the disengaged position, the eccentric arrangement rotates in one of a clockwise and a counter-clockwise direction about the eccentric axis.

Abstract: Microparticles are prepared by a method that includes: (a) forming a layer comprising a first polymer on a solid surface by depositing a first composition one or more times on the solid surface, wherein the first composition comprises the first polymer and a first solvent, and evaporating the first solvent in the first composition; (b) forming one or more layers comprising a second polymer and a therapeutic agent by depositing a second composition on all or part of the layer formed in step (a), wherein the second composition comprises the second polymer, the therapeutic agent, and a second solvent; and evaporating the second solvent in the second composition; and (c) forming an additional layer comprising a third polymer by depositing a third composition one or more times on a previously formed layer, wherein the third composition comprises the third polymer and a third solvent; and evaporating the third solvent in the third composition.

Abstract: Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed. Also disclosed are methods of treating diseases and disorders using the aqueous pharmaceutical formulations disclosed herein.

Abstract: A latch assembly includes a chassis, a latch bolt moveably mounted on the chassis and having a closed position for retaining a striker and an open position for releasing the striker, a pawl having an engaged position at which the pawl is engaged with the latch bolt to hold the latch bolt in the closed position and a disengaged position at which the pawl is disengaged from the latch bolt, thereby allowing the latch bolt to move to the open position, an eccentric arrangement defining an eccentric axis and a pawl axis remote from the eccentric axis. The eccentric arrangement is rotatable about the eccentric axis, and the pawl is rotatable about the pawl axis. When the pawl moves from the engaged position to the disengaged position, the eccentric arrangement rotates in one of a clockwise and a counter-clockwise direction about the eccentric axis.

Abstract: A latch assembly includes a chassis, a latch bolt moveably mounted on the chassis and having a closed position for retaining a striker and an open position for releasing the striker, a pawl having an engaged position at which the pawl is engaged with the latch bolt to hold the latch bolt in the closed position and a disengaged position at which the pawl is disengaged from the latch bolt, thereby allowing the latch bolt to move to the open position, an eccentric arrangement defining an eccentric axis and a pawl axis remote from the eccentric axis. The eccentric arrangement is rotatable about the eccentric axis, and the pawl is rotatable about the pawl axis. When the pawl moves from the engaged position to the disengaged position, the eccentric arrangement rotates in one of a clockwise and a counter-clockwise direction about the eccentric axis.

Abstract: Microparticles are prepared by a method that includes: (a) forming a layer comprising a first polymer on a solid surface by depositing a first composition one or more times on the solid surface, wherein the first composition comprises the first polymer and a first solvent, and evaporating the first solvent in the first composition; (b) forming one or more layers comprising a second polymer and a therapeutic agent by depositing a second composition on all or part of the layer formed in step (a), wherein the second composition comprises the second polymer, the therapeutic agent, and a second solvent; and evaporating the second solvent in the second composition; and (c) forming an additional layer comprising a third polymer by depositing a third composition one or more times on a previously formed layer, wherein the third composition comprises the third polymer and a third solvent; and evaporating the third solvent in the third composition.

Abstract: A drive mechanism includes an electric motor, a rotor driven by the electric motor, and a worm screw driven by the rotor. The drive mechanism further includes a wheel driven by the worm screw, the wheel transmitting movement of the electric motor to a vehicle closure, and a clutch on the rotor connecting the worm screw to the electric motor or disconnecting the worm screw from the electric motor.

Abstract: A motor arrangement includes a rotor with a north rotor magnetic pole and a south rotor magnetic pole, the rotor being rotatable about a rotor axis between a first rotor position and a second rotor position. The rotor includes a first rotor abutment and a second rotor abutment. The motor arrangement includes a stator having a first stator magnetic pole and a second stator magnetic pole, the stator having a first stator condition in which the first stator magnetic pole is a north stator magnetic pole and the second stator magnetic pole is a south stator magnetic pole, and a second stator condition in which the first stator magnetic pole is a south stator magnetic pole and the second stator magnetic pole is a north stator magnetic pole.

Abstract: A latch assembly includes a chassis, a latch bolt moveably mounted on the chassis and having a closed position for retaining a striker and an open position for releasing the striker, a pawl having an engaged position at which the pawl is engaged with the latch bolt to hold the latch bolt in the closed position and a disengaged position at which the pawl is disengaged from the latch bolt, thereby allowing the latch bolt to move to the open position, an eccentric arrangement defining an eccentric axis and a pawl axis remote from the eccentric axis. The eccentric arrangement is rotatable about the eccentric axis, and the pawl is rotatable about the pawl axis. When the pawl moves from the engaged position to the disengaged position, the eccentric arrangement rotates in one of a clockwise and a counter-clockwise direction about the eccentric axis.

Abstract: An anti-pinch system of a vehicle closure includes a detection system for detecting pinching and a clutch to disconnect the vehicle closure from a closure driving mechanism following detection of pinching by the detection system. The closure drive mechanism can be disengaged to prevent an increase in pinching during the time required to reverse the movement of the closure driving mechanism.

Abstract: An anti-pinch system of a vehicle closure includes a detection system for detecting pinching and a clutch to disconnect the vehicle closure from a closure driving mechanism following detection of pinching by the detection system. The closure drive mechanism can be disengaged to prevent an increase in pinching during the time required to reverse the movement of the closure driving mechanism.

Abstract: A latch assembly includes a chassis and a rotatable claw-type latch bolt moveably mounted on the chassis. The latch bolt has a closed position for retaining a striker and an open position for releasing the striker. The latch bolt is provided with a latch abutment remote from a center of rotation. The latch assembly further includes a pawl rotatable about a pawl axis and having an engaged position for holding the latch bolt in the closed position and a disengaged position that allows the latch bolt to move to the open position. The latch assembly includes an eccentric arrangement defining a first axis and the pawl axis remote from the first axis. The latch assembly also includes a reset lever rotatably fixed to the eccentric arrangement for mutual rotation with the eccentric arrangement about the first axis. The latch assembly includes a biasing lever configured to transmit a biasing force to the reset lever at a position remote from the first axis and to the latch bolt via the latch abutment.

Abstract: This is a device which will make the monitoring and regulation of chemicals in a pool easy and convenient. It will also make it as automatic as possible for the user to accurately monitor the chemical levels and add the appropriate chemicals. The user may preset the amount and time of the specific chemicals to be added and may adjust for factors such as usage and time of year.

Abstract: A latch arrangement includes a power control system which can be energized to prevent opening of a door latch by controlling the movement of a release mechanism within a latch. A sensor monitors an operative state of the release mechanism. In the event the sensor detects an unauthorized attempt to open a door, the power control system is energized, thereby preventing unauthorized opening of the latch. The sensor can monitor the direct movement of a door handle. Additionally, or alternatively, the sensor can monitor an internal component within the release mechanism to monitor movements indicative of movement of the door handle.

Abstract: A latch arrangement includes a lever movable in response to movement of a door lever. A controller is configured for selectively preventing movement of the lever. The controller includes a mono-stable blocking element in the form of a bi-metallic strip which can be operated such that a distal end acts to block movement of the lever. The controller also includes a bi-stable blocking element having a nib that can be moved to an extended position to block movement of the lever. Both blocking elements can be operated at the same time. When either of the blocking elements are arranged in the path of the release lever, unlatching of the door is prevented.

Abstract: A handle includes movable flaps. The movement of one of the flaps in one direction moves another of the flaps in another direction. The distance between the flaps is constant along the flaps. A door can include the handle. Movement of the flaps in a manner similar to that of a pair of scissors can be prevented, preventing any risk of pinching when actuating the flaps.