Patents by Inventor Chris Saxby

Chris Saxby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monocyte and macrophage binding aptamers and their application
    Patent number: 12215324
    Abstract: Provided herein are compositions comprising aptamers that specifically bind monocytes and/or macrophage and methods for their use. These aptamer compositions can be used in methods for isolating and/or enriching monocytes and/or macrophages or depleting cell populations of monocytes and/or macrophages. Further provided are methods of using the aptamers or cell populations generated using them in the methods disclosed herein for therapies and/or drug delivery.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: February 4, 2025
    Assignees: University of Washington, Seattle Children's Hospital
    Inventors: Suzie Hwang Pun, Meilyn Sylvestre, Nataly Kacherovsky, Emmeline Cheng, Ian Cardle, Chris Saxby
  • ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN
    Publication number: 20240226160
    Abstract: Activity-inducible fusion proteins whose activity is post-translationally regulated utilizing a hsp90 binding domain and a drug molecule are described. In the absence of the drug molecule, the activity-inducible fusion proteins are inactivated but can be activated by a relevant physiological parameter in the presence of the drug molecule. Examples of the activity-inducible fusion proteins include chimeric antigen receptors (CAR) wherein the relevant physiological parameter is antigen binding.
    Type: Application
    Filed: February 11, 2022
    Publication date: July 11, 2024
    Applicant: Seattle Children's Hospital d/b/a Seattle Children's Research Institute
    Inventors: Ryan Koning, Adam Johnson, Chris Saxby, Michael C. Jensen, Ian Blumenthal, Aquene Reid
  • ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN
    Publication number: 20240131072
    Abstract: Activity-inducible fusion proteins whose activity is post-translationally regulated utilizing a hsp90 binding domain and a drug molecule are described. In the absence of the drug molecule, the activity-inducible fusion proteins are inactivated but can be activated by a relevant physiological parameter in the presence of the drug molecule. Examples of the activity-inducible fusion proteins include chimeric antigen receptors (CAR) wherein the relevant physiological parameter is antigen binding.
    Type: Application
    Filed: February 11, 2022
    Publication date: April 25, 2024
    Applicant: Seattle Children's Hospital d/b/a Seattle Children's Research Institute
    Inventors: Ryan Koning, Adam Johnson, Chris Saxby, Michael C. Jensen, Ian Blumenthal, Aquene Reid
  • MONOCYTE AND MACROPHAGE BINDING APTAMERS AND THEIR APPLICATION
    Publication number: 20230017777
    Abstract: Provided herein are compositions comprising aptamers that specifically bind monocytes and/or macrophage and methods for their use. These aptamer compositions can be used in methods for isolating and/or enriching monocytes and/or macrophages or depleting cell populations of monocytes and/or macrophages. Further provided are methods of using the aptamers or cell populations generated using them in the methods disclosed herein for therapies and/or drug delivery.
    Type: Application
    Filed: June 24, 2022
    Publication date: January 19, 2023
    Applicants: University of Washington, Seattle Children's Hospital d/b/a Seattle Children's Research Institute
    Inventors: Suzie Hwang Pun, Meilyn Sylvestre, Nataly Kacherovsky, Emmeline Cheng, Ian Cardle, Chris Saxby