Abstract: The invention relates to compounds of the Formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X2, X4, X5 and X1 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of Formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of Formula 1.

Abstract: An improved reclaimer device and a method thereof, wherein overall efficiency is maximized via decreased installation and operation costs, and wherein performance is optimized via aggressive treatment of reclaimed bulk material prior to and during exit from the reclaim boom, thereby minimizing costly downtime by preventing jams caused by clumped materials and ensuring the efficient passage of appropriately sized bulk materials from a preferred, generally horizontal conveyor into an out-feed chute and conveyor.