Abstract: The present disclosure relates to extracellular vesicles (e.g., exosomes) comprising a biologically active molecule covalently linked to the extracellular vesicle via an optimized linker and an anchoring moiety, which may be useful as an agent for the prophylaxis or treatment of cancer or other diseases. Also provided herein are methods for producing the extracellular vesicles and methods for using the extracellular vesicles to treat diseases or disorders.

Abstract: A server system obtains geospatial data collected from a field device and associated with a first project, wherein the data is obtained in accordance with a code list specifying a plurality of data values associated with a plurality of projects including the first project; parses the geospatial data in accordance with one or more quality control operations; classifies the parsed geospatial data; selects a first extract-transform-load (ETL) tool of a plurality of ETL tools in accordance with the identified project type; processes, using the selected ETL tool, the parsed geospatial data into a first data scheme; and uploads the first data scheme to a geospatial information system (GIS) database for display in a user interface of a web application that integrates the geospatial data with non-spatial data corresponding to the first project.

Abstract: A method may include receiving a sound signal and identifying a plurality of components of the sound signal. The plurality of components may include a tonal component and an atonal component. The method may further include generating a first stimulation signal based on the tonal component of the sound signal, wherein the first stimulation signal is configured for application by a first stimulator to provide an acoustic output from a hearing prosthesis system. In addition, the method may include generating a second stimulation signal based on the atonal component of the sound signal, wherein the second stimulation signal is configured for application by a second stimulator to provide an electrical output from the hearing prosthesis system.

Abstract: A method may include receiving a sound signal and identifying a plurality of components of the sound signal. The plurality of components may include a tonal component and an atonal component. The method may further include generating a first stimulation signal based on the tonal component of the sound signal, wherein the first stimulation signal is configured for application by a first stimulator to provide an acoustic output from a hearing prosthesis system. In addition, the method may include generating a second stimulation signal based on the atonal component of the sound signal, wherein the second stimulation signal is configured for application by a second stimulator to provide an electrical output from the hearing prosthesis system.

Abstract: Various embodiments include spectrometers comprising diffraction gratings monolithically integrated with other optical elements. These optical elements may include slits and mirrors. The mirrors and gratings may be curved. In one embodiment, the mirrors are concave and the grating is convex. The mirrors and grating may be concentric or nearly concentric.