Patents by Inventor Chris Xiangyang LU

Chris Xiangyang LU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-ACVR2A ANTIBODIES AND USES THEREOF
    Publication number: 20240368289
    Abstract: Anti-ACVR2A antibodies or antigen binding fragment thereof and uses thereof for inhibiting or antagonizing ACVR2A. The antibodies and antigen binding fragments may be used in therapeutic methods for treating ACVR2A or ACVR2A ligands associated diseases or disorders, which are ameliorated or improved by inhibition of ACVR2A.
    Type: Application
    Filed: September 2, 2022
    Publication date: November 7, 2024
    Applicant: LAEKNA THERAPEUTICS SHANGHAI CO., LTD.
    Inventors: Chris Xiangyang LU, Xiang-Ju Justin GU, Ruipeng ZHANG, Mengxue YANG, Minhua ZHANG, Meijuan HU
  • DEPLETION OF ACTIVATED HEPATIC STELLATE CELLS (HSCS) AND USES THEREOF
    Publication number: 20240254239
    Abstract: A binding molecule comprising a binding domain that binds to an antigen expressed on an activated hepatic stellate cells (HSC), and a functional domain that is capable of enhancing an antibody effector function such as antibody-dependent cell-mediated cytotoxicity (ADCC) toward activated HSCs. Uses of such binding molecule are also provided herein.
    Type: Application
    Filed: June 30, 2022
    Publication date: August 1, 2024
    Applicant: LAEKNA THERAPEUTICS SHANGHAI CO., LTD.
    Inventors: Chris Xiangyang LU, Xiang-Ju Justin GU, Minhua ZHANG, Ruipeng ZHANG
  • ANTIBODIES TARGETING BONE MORPHOGENETIC PROTEIN 9 (BMP9) AND METHODS THEREFOR
    Publication number: 20190153084
    Abstract: The present invention relates to isolated antibodies and antigen-binding fragments thereof which bind human BMP9 and compositions and methods of use thereof.
    Type: Application
    Filed: July 5, 2018
    Publication date: May 23, 2019
    Applicant: NOVARTIS AG
    Inventors: Zijun Chen, Sujun Deng, Yun He, Dagang Huang, Markus Kugler, Qian Li, Chris Xiangyang Lu, Xiao Luo, Yongqiang Shan, Kathrin Ulrike Tissot-Daguette, Jing Wu
  • DIAGNOSTIC BIOMARKERS FOR FIBROTIC DISORDERS
    Publication number: 20180280476
    Abstract: The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention also provides methods of assessing whether a subject has or is at risk of developing a fibrotic disorder by detecting levels of BMP9 and/or BMP10. Further provided are methods of assessing the efficacy of a treatment regimen for treating a fibrotic disorder by detecting and comparing pre-treatment levels of BMP9 and BMP10 with post-treatment levels of BMP9 and BMP10.
    Type: Application
    Filed: June 8, 2018
    Publication date: October 4, 2018
    Applicant: NOVARTIS AG
    Inventors: Alan Buckler, Chao-Min Chen, Chantale T. Guy, Jeffrey Hewett, Chris Xiangyang Lu, Jing Wu
  • Antibodies targeting bone morphogenetic protein 9 (BMP9) and methods therefor
    Patent number: 10047155
    Abstract: The present invention relates to isolated antibodies and antigen-binding fragments thereof which bind human BMP9 and compositions and methods of use thereof.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: August 14, 2018
    Assignee: NOVARTIS AG
    Inventors: Zijun Chen, Sujun Deng, Yun He, Dagang Huang, Markus Kugler, Qian Li, Chris Xiangyang Lu, Xiao Luo, Yongqiang Shan, Kathrin Ulrike Tissot-Daguette, Jing Wu
  • ANTIBODIES TARGETING BONE MORPHOGENETIC PROTEIN 9 (BMP9) AND METHODS THEREFOR
    Publication number: 20160355583
    Abstract: The present invention relates to isolated antibodies and antigen-binding fragments thereof which bind human BMP9 and compositions and methods of use thereof.
    Type: Application
    Filed: May 26, 2016
    Publication date: December 8, 2016
    Applicant: NOVARTIS AG
    Inventors: Zijun CHEN, Sujun DENG, Yun HE, Dagang HUANG, Markus KUGLER, Qian LI, Chris Xiangyang LU, Xiao LUO, Yongqiang SHAN, Kathrin Ulrike TISSOT-DAGUETTE, Jing WU