Patents by Inventor Chrishan Julian Alles RAMACHANDRA

Chrishan Julian Alles RAMACHANDRA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Re-trafficking of herg reverses long QT syndrome 2 phenotype in human iPS-derived cardiomyocytes
    Patent number: 9797883
    Abstract: The present invention relates to generating hiPSC-derived cardiomyocytes and embryoid bodies that recapitulate the disease phenotype of Long QT Syndrome and their use in developing pharmacological treatments thereof. The present invention also includes the use of a compound which inhibits the ubiquitin-proteasome pathway for the preparation of a medicament for the prophylaxis or treatment of a disease associated with prolonged ventricular repolarization (cardiac arrhythmia) caused by one or more mutations in the amino acid sequence of the hERG potassium channel.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 24, 2017
    Assignee: Singapore Health Services Pte Ltd
    Inventors: Winston Se Ngie Shim, Ashish Mehta, Chrishan Julian Alles Ramachandra, Philip En Hou Wong
  • RE-TRAFFICKING OF HERG REVERSES LONG QT SYNDROME 2 PHENOTYPE IN HUMAN IPS-DERIVED CARDIOMYOCYTES
    Publication number: 20160033481
    Abstract: The present invention relates to generating hiPSC-derived cardiomyocytes and embryoid bodies that recapitulate the disease phenotype of Long QT Syndrome and their use in developing pharmacological treatments thereof. The present invention also includes the use of a compound which inhibits the ubiquitin-proteasome pathway for the preparation of a medicament for the prophylaxis or treatment of a disease associated with prolonged ventricular repolarization (cardiac arrhythmia) caused by one or more mutations in the amino acid sequence of the hERG potassium channel.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Inventors: Winston Se Ngie SHIM, Ashish MEHTA, Chrishan Julian Alles RAMACHANDRA, Philip En Hou WONG