Patents by Inventor Christelle Bourgeois

Christelle Bourgeois has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tryptophan as a functional replacement for ADP-ribose-arginine in recombinant proteins
    Patent number: 7923535
    Abstract: A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: April 12, 2011
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, University of Massachusetts
    Inventors: Joel Moss, Linda Stevens, Christelle Bourgeois, Rita Bortell
  • TRYPTOPHAN AS A FUNCTIONAL REPLACEMENT FOR ADP-RIBOSE-ARGININE IN RECOMBINANT PROTEINS
    Publication number: 20090203878
    Abstract: A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
    Type: Application
    Filed: April 24, 2009
    Publication date: August 13, 2009
    Inventors: Joel Moss, Linda Stevens, Christelle Bourgeois, Rita Bortell
  • Tryptophan as a functional replacement for ADP-ribose-arginine in recombinant proteins
    Patent number: 7541139
    Abstract: A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: June 2, 2009
    Assignees: The United States of America as represented by the Department of Health and Human Services, University of Massachusetts
    Inventors: Joel Moss, Linda Stevens, Christelle Bourgeois, Rita Bortell
  • Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins
    Publication number: 20060074037
    Abstract: A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
    Type: Application
    Filed: June 27, 2003
    Publication date: April 6, 2006
    Inventors: Joel Moss, Linda Stevens, Christelle Bourgeois, Rita Bortell