Abstract: The identification and the use of compounds which activate the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1 is provided. An in vitro method for screening for candidate compounds includes: (a) bringing at least one test compound in contact with a sample of keratinocytes in vitro; (b) measuring the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1, in the keratinocytes; and (c) selecting the compounds for which an activation of at least 1.4 fold of the expression of at least one of the LARGE, HS6ST2 and ST8SIA1 genes is measured in the keratinocytes treated in (a) compared with the untreated keratinocytes. The candidate compounds may be useful for preventing and/or attenuating ageing, and/or for hydrating skin.

Abstract: The identification and the use of compounds which activate the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1, for preventing and/or attenuating ageing, and/or for hydrating skin is provided. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin, and/or for hydrating the skin, includes the following steps: (a) bringing at least one test compound in contact with a sample of keratinocytes; (b) measuring the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1, in said keratinocytes; (c) selecting the compounds for which an activation of at least 1.4 fold of the expression of at least one of said genes is measured in the keratinocytes treated in (a) compared with the untreated keratinocytes.

Abstract: The present invention relates to a cosmetic composition containing an extract of flowers of Camellia Japonica Alba Plena, as well as the cosmetic use thereof, for moisturizing and/or protecting human skin against drying. It also relates to an extract of flowers of Camellia Japonica Alba Plena, characterized in that it can be obtained by extraction of flowers by at least one alcoholic solvent.

Abstract: The invention relates to an extract of Vanilla planifolia, consisting in a liposoluble fraction, to a cosmetic or dermatological composition containing it, and to cosmetic and dermatological methods using same, especially in the treatment of skin ageing.

Abstract: The invention relates to the identification and the use of compounds which activate the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1, for preventing and/or attenuating ageing, and/or for hydrating skin. The invention thus relates to an in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin, and/or for hydrating the skin, including the following steps: a. bringing at least one test compound in contact with a sample of keratinocytes; b. measuring the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1, in the keratinocytes; c. selecting the compounds for which an activation of at least 1.4 fold of the expression of at least one of the genes is measured in the keratinocytes treated in a. compared with the untreated keratinocytes.

Abstract: The present invention relates to a cosmetic composition containing an extract of flowers of Camellia Japonica Alba Plena, as well as the cosmetic use thereof, for moisturizing and/or protecting human skin against drying. It also relates to an extract of flowers of Camellia Japonica Alba Plena, characterized in that it can be obtained by extraction of flowers by at least one alcoholic solvent.

Abstract: A method for screening active agents capable of treating at least one cutaneous sign of aging. The agents are identified based on their ability to stimulate fructosamine-3-kinase (FN3K) and/or fructosamine-3-kinase-related protein (FN3K RP) expression.

Abstract: A cosmetic process for caring for human skin, which is intended for preventing and/or combating at least one sign of ageing of the skin or the ‘orange peel’ appearance of the skin, includes the topical application to the skin of a composition containing at least one active agent for stimulating the expression of FN3K and/or FN3K RP. The use of this active agent for preventing and/or combating at least one sign of ageing of the skin or the ‘orange peel’ appearance of the skin associated with cellulite is also disclosed.

Abstract: A cosmetic process for caring for human skin, intended for preventing or combating the cutaneous signs resulting from non-pathological impairment of the barrier function, includes the topical application to the skin of a composition containing at least one active agent for stimulating the expression of FN3K and/or FN3K RP. The use of this active agent for preventing or combating the cutaneous signs resulting from non-pathological impairment of the barrier function is also disclosed.

Abstract: The invention relates to an extract of vanilla originating from at least one species of vanilla plant (family Orchidaceae), to the method for obtaining it, to a cosmetic or dermatological composition containing it, and to its use as a polyfunctional active agent in a cosmetic or dermatological composition, for the prevention and/or treatment of alterations of the skin due, in particular, to aging, to physiological mechanisms related to aging, or to conditions related to these mechanisms.