Patents by Inventor Christen D. FORBES

Christen D. FORBES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High throughput method for measuring the protease activity of complement C3 convertase
    Patent number: 11913951
    Abstract: Provided herein are high throughput methods for measuring the protease activity of the complement C3 convertase by detecting the consumption of C3 or the production of C3a in vivo and in vitro.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: February 27, 2024
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventor: Christen D. Forbes
  • METHOD FOR MEASURING THE PROTEASE ACTIVITY OF C3 AND C5 CONVERTASE OF THE ALTERNATIVE COMPLEMENT PATHWAY
    Publication number: 20230265481
    Abstract: A method for measuring the protease activity of a convertase of the alternative complement pathway is provided. The method typically comprises immobilizing a biotinylated C3b on a solid phase coated with a biotin binding protein. Substantially homogeneous components of the alternative complement pathway may be incubated with the immobilized C3b in a serum free and a gelatin free buffer, to form a convertase. The activity of the convertase is generally measured with an immunoassay.
    Type: Application
    Filed: September 26, 2022
    Publication date: August 24, 2023
    Inventors: Krista K. JOHNSON, Christen D. FORBES
  • Lysosomal acid lipase deficiency compositions and methods
    Patent number: 11235036
    Abstract: Compositions and methods relating to potentially pathogenic mutations in the nucleotide sequence of a human LIPA gene. Some LIPA gene products have been discovered to be associated with reduced lysosomal acid lipase (LAL) activity.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: February 1, 2022
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Andrew Hutchinson, John V. W. Reynders, Guillermo del Angel, Nina Jain, Christen D. Forbes, Xiao-Qin Ren, Barbara Burton
  • HIGH THROUGHPUT METHOD FOR MEASURING THE PROTEASE ACTIVITY OF COMPLEMENT C3 CONVERTASE
    Publication number: 20210025886
    Abstract: Provided herein are high throughput methods for measuring the protease activity of the complement C3 convertase by detecting the consumption of C3 or the production of C3a in vivo and in vitro.
    Type: Application
    Filed: March 21, 2019
    Publication date: January 28, 2021
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventor: Christen D. FORBES
  • N-acetyl-alpha-D-glucosaminidase deficiency compositions and methods
    Patent number: 10633705
    Abstract: Compositions and methods relating to potentially pathogenic mutations in the nucleotide sequence of a human NAGLU gene. Some NAGLU gene variants have been discovered to be associated with reduced N-acetyl-?-D-glucosaminidase (NAGLU) activity.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: April 28, 2020
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Rui-Ru Ji, Andrew Hutchinson, Nina Jain, Christen D. Forbes
  • LYSOSOMAL ACID LIPASE DEFICIENCY COMPOSITIONS AND METHODS
    Publication number: 20190151420
    Abstract: Compositions and methods relating to potentially pathogenic mutations in the nucleotide sequence of a human LIPA gene. Some LIPA gene products have been discovered to be associated with reduced lysosomal acid lipase (LAL) activity.
    Type: Application
    Filed: June 16, 2017
    Publication date: May 23, 2019
    Applicant: ALEXION PHARMACEUTICALS, INC.
    Inventors: Andrew Hutchinson, John V.W. Reynders, Guillermo del Angel, Nina Jain, Christen D. Forbes, Xiao-Qin Ren, Barbara Burton
  • N-ACETYL-alpha-D-GLUCOSAMINIDASE DEFICIENCY COMPOSITIONS AND METHODS
    Publication number: 20180105879
    Abstract: Compositions and methods relating to potentially pathogenic mutations in the nucleotide sequence of a human NAGLU gene. Some NAGLU gene variants have been discovered to be associated with reduced N-acetyl-?-D-glucosaminidase (NAGLU) activity.
    Type: Application
    Filed: October 11, 2017
    Publication date: April 19, 2018
    Inventors: Rui-Ru Ji, Andrew Hutchinson, Nina Jain, Christen D. Forbes
  • A METHOD FOR MEASURING THE PROTEASE ACTIVITY OF C3 AND C5 CONVERTASE OF THE ALTERNATIVE COMPLEMENT PATHWAY
    Publication number: 20180087087
    Abstract: A method for measuring the protease activity of a convertase of the alternative complement pathway is provided. The method typically comprises immobilizing a biotinylated C3b on a solid phase coated with a biotin binding protein. Substantially homogeneous components of the alternative complement pathway may be incubated with the immobilized C3b in a serum free and gelatin free buffer, to form a convertase. The activity of the convertase is generally measured with an immunoassay.
    Type: Application
    Filed: March 28, 2016
    Publication date: March 29, 2018
    Inventors: Krista K. JOHNSON, Christen D. FORBES
  • A METHOD FOR MEASURING THE PROTEASE ACTIVITY OF FACTOR D OF THE ALTERNATIVE COMPLEMENT PATHWAY
    Publication number: 20180074077
    Abstract: A method for measuring the protease activity of Factor D for its natural substrate is provided. Factor D activity may be measured with an immunoassay or a biosensor. The method typically comprises immobilizing a biotinylated C3b on a solid phase coated with a biotin binding protein. Substantially homogeneous components of the alternative complement pathway may be incubated with the immobilized C3b to form a convertase. An immunoassay or a biosensor is generally used to measure the formation of Bb.
    Type: Application
    Filed: March 29, 2016
    Publication date: March 15, 2018
    Inventors: Krista K. JOHNSON, Christen D. FORBES