Patents by Inventor Christen M. Giadomenico

Christen M. Giadomenico has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Certain pyridyl hydrazines and hydrazides useful for protein labeling
    Patent number: 5206370
    Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: April 27, 1993
    Assignee: Johnson Matthey, Inc.
    Inventors: David A. Schwartz, Michael J. Abrams, Christen M. Giadomenico, Jon A. Zubieta