Patents by Inventor Christen M. Giandomenico
Christen M. Giandomenico has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150196494Abstract: The invention provides an oral dosage form for the anti-cancer drug picoplatin comprising a core and a coating, the dosage form being free of redox-active, metal salts. The core of the tablet is a substantially dry powder comprising about 10 to 60 wt % picoplatin wherein the picoplatin is a particulate of less than about 10 microns average particle diameter, about 40-80 wt % of a filler comprising a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate, and an effective amount of up to about 5 wt % of a lubricant. The dosage form can further include a dispersant.Type: ApplicationFiled: March 25, 2015Publication date: July 16, 2015Inventors: Alistair J. Leigh, Christopher A. Procyshyn, Ernest S.Y. Wong, Christen M. Giandomenico
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Publication number: 20130183433Abstract: The invention provides an oral dosage form for the anti-cancer drug picoplatin comprising a core and a coating, the dosage form being free of redox- active metal salts. The core of the tablet is a substantially dry powder comprising about 10 to 60 wt % picoplatin wherein the pieoplatin is a particulate of less than about 10 microns average particle diameter, about 40-80 wt % of a filler comprising a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate, and an effective amount of up to about 5 wt % of a lubricant. The dosage form can further include a dispersant.Type: ApplicationFiled: August 16, 2012Publication date: July 18, 2013Applicant: Poniard Pharmaceuticals, Inc.Inventors: Alistair J. Leigh, Christopher A. Procyshyn, Ernest S.Y. Wong, Christen M. Giandomenico
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Publication number: 20110033528Abstract: The invention provides an oral dosage form for the anti-cancer drug picoplatin comprising a core and a coating, the dosage form being free of redox-active metal salts. The core of the tablet is a substantially dry powder comprising about 10 to 60 wt % picoplatin wherein the picoplatin is a particulate of less than about 10 microns average particle diameter, about 40-80 wt % of a filler comprising a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate, and an effective amount of up to about 5 wt % of a lubricant. The dosage form can further include a dispersant.Type: ApplicationFiled: August 5, 2009Publication date: February 10, 2011Applicant: Poniard Pharmaceuticals, Inc.Inventors: Alistair J. Leigh, Christopher A. Procyshyn, Ernest S.Y. Wong, Christen M. Giandomenico
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Patent number: 6894049Abstract: The present invention relates to platinum antitumor drugs. In particular, it relates to platinum complexes having formula Ia or Ib or a pharmaceutically acceptable salt thereof wherein: each A is independently an anion; each B is independently halo, hydroxy, carboxylate, carbamate or a carbonate ester, Z is a substituted 5- or 6-membered, heterocyclic moiety wherein at least one substituent sterically hinders access of the Pt atom to a DNA strand of a tumor cell, and wherein Z is other than pyridine; and X is NH3 or mono- or dialkyl substituted NH3. which are active against cancer cells and have improved aqueous solubility and activity.Type: GrantFiled: October 4, 2000Date of Patent: May 17, 2005Assignee: AnorMED, Inc.Inventors: Ernest S. Y. Wong, Christen M. Giandomenico
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Patent number: 6489472Abstract: Cyclic polyamines containing N nitrogens on the ring are protected with high yields in a N-1 manner, e.g. all protected but one amino group, by using certain fluoro-containing agents that offer easy deprotection. Preferably, a new process for preparing 1,1′-[1,4-phenylenebis (methylene)]-bis1,4,8,11-tetraazacyclotetradecane is disclosed.Type: GrantFiled: September 28, 2001Date of Patent: December 3, 2002Assignee: AnorMED, Inc.Inventors: Christen M. Giandomenico, Wen Yang
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Publication number: 20020058807Abstract: Cyclic polyamines containing N nitrogens on the ring are protected with high yields in a N-1 manner, e.g. all protected but one amino group, by using certain fluoro-containing agents that offer easy deprotection. Preferably, a new process for preparing 1,1′-[1,4-phenylenebis (methylene)]-bis1,4,8,11-tetraazacyclotetradecane is disclosed.Type: ApplicationFiled: September 28, 2001Publication date: May 16, 2002Inventors: Christen M. Giandomenico, Wen Yang
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Patent number: 6217845Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species. The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.Type: GrantFiled: November 6, 1997Date of Patent: April 17, 2001Assignee: AnorMed, Inc.Inventors: David A. Schwartz, Michael J. Abrams, Christen M. Giandomenico, Jon A. Zubieta
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Patent number: 5753520Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species. The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.Type: GrantFiled: February 6, 1995Date of Patent: May 19, 1998Assignee: Johnson Matthey Inc.Inventors: David A. Schwartz, Michael J. Abrams, Christen M. Giandomenico, Jon A. Zubieta
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Patent number: 5420285Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species. The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.Type: GrantFiled: March 4, 1993Date of Patent: May 30, 1995Assignee: Johnson Matthey, Inc.Inventors: David A. Schwartz, Michael J. Abrams, Christen M. Giandomenico, Jon A. Zubieta
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Patent number: 5281578Abstract: Gallium(III) complexes of general formula I, ##STR1## in which X=O.sub.2 CR.sup.2, halogen, NO.sub.3 or -OA, R.sup.1 =H, alkyl, alkoxy, halogen, NO.sub.2 or amino, R.sup.2 =alkyl, alkoxy or aryl, each of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 =H or alkyl and n=0, 1 or 2, or when n=0 and R.sup.3 and R.sup.6 both=H, then R.sup.4 and R.sup.5 together may form tetramethylene, and A=an identical gallium complex moiety to that to which the oxygen atom is linked, are well absorbed orally, and are indicated as medicaments for hypercalcemia and for cancer chemotherapy.Type: GrantFiled: May 19, 1992Date of Patent: January 25, 1994Assignee: Johnson Matthey Public Limited CompanyInventors: Fontaine C. Bradley, Danielle T. Frost, Christen M. Giandomenico
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Patent number: 5244919Abstract: A Pt(IV) complex of the formula ##STR1## wherein A and A' are NH.sub.3 or an amino group; R and R.sup.1 are hydrogen, alkyl, alkenyl, aryl, aralkyl, alkylamino or alkoxy or functionalized derivatives thereof; and X is halogen or alkyl mono- or dicarboxylate. The complexes have high antitumor activity, particularly when administered orally.Type: GrantFiled: July 1, 1991Date of Patent: September 14, 1993Assignee: Johnson Matthey, Inc.Inventors: Michael J. Abrams, Christen M. Giandomenico, Barry A. Murrer, Jean F. Vollano
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Patent number: 5100885Abstract: Hypoxic cells are rendered more sensitive to irradiation by subjecting the cells to treatment with a Cu(II) coordination compound.Type: GrantFiled: August 1, 1989Date of Patent: March 31, 1992Assignee: Johnson Matthey, Inc.Inventors: Michael J. Abrams, Bradley Fontaine, Christen M. Giandomenico
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Patent number: 4851403Abstract: The present invention relates to a method of potentiating radiation therapy using Co(III) complexes of water soluble, synthetic meso-substituted porphyrins. The method results in the sensitization of both well oxygenated (oxic) and oxygen deficient (hypoxic) tumor cells.Type: GrantFiled: April 21, 1987Date of Patent: July 25, 1989Assignee: Johnson Matthey, Inc.Inventors: Donald H. Picker, Michael J. Abrams, Jean F. Vollano, Christen M. Giandomenico