Abstract: A pyrotechnic tightening device 1 of a safety belt unit having a force limiting unit, comprising—a gas generator, and—a piston 19, which is guided in a pipe and which closes a pressure chamber inside the pipe, wherein—a pressure can be applied to the pressure chamber by the gas generator, and—the piston can be driven by the pressure present in the pressure chamber to perform a tightening movement which can be transmitted by means of a force transmitting unit to the safety belt, wherein—the piston is formed in two parts consisting of a main body and a contact part arranged on the side of the main body facing the force transmitting unit, wherein—the contact part has a greater strength than the main body, wherein—the main body surrounds the contact part form fittingly at the end face facing the force transmitting device.

Abstract: A method for operating a motor vehicle including a drive mechanism having at least a first drive unit and at least a second drive unit is provided. The method includes providing a drive torque directed at the driving of the motor vehicle in a first setting of the drive mechanism only by means of the second drive unit and in a second setting by means of both drive units, wherein upon exceeding a start-up threshold value by a demanded preset power there is a switching from the first setting to the second setting, and upon falling below a shut-off threshold value by the demanded preset power there is a switching from the second setting to the first setting. It is provided that the start-up threshold value and/or the shut-off threshold value is determined in dependence on a driving resistance of the motor vehicle and/or a vehicle weight of the motor vehicle. A motor vehicle employing the method is also provided.

Abstract: A measurement setup for measuring attenuation through an irregular surface of a device under test is described. The measurement setup includes a positioning system, a reference reflector, and a three dimensional imaging system. The measurement setup has a reference state and a measurement state, wherein respective images are taken in the different states. The imaging system is configured to compare the images taken in the reference state and the measurement state to determine the attenuation of the device under test. Further, a reference reflector as well as a method for measuring attenuation are described.

Abstract: Transporting loads is a fundamental component of intralogistics. Autonomous industrial trucks can be used for this. The autonomous industrial truck claimed according to the invention is able, by means of the implemented navigation, load receiving and load placing methods, to ensure efficient transporting of loads. The invention relates to an autonomous industrial truck having a rearwardly-directed sensor unit for detecting the load and the loading environment and implemented process sequences for approaching the load, receiving the load and placing the load.

Abstract: A process for the additive manufacture of a metallic and/or vitreous and/or ceramic component, a mixture of substrate particles and an at least two-phase binder is firstly provided. The mixture is preferably provided as composite particles, so that the substrate particles adhere to one another by the at least two-phase binder. The mixture is selectively melted layerwise by electromagnetic radiation so that a shaped part is additively produced. The shaped part is taken out from the mixture which has not been melted and the at least two-phase binder is subsequently removed, preferably successively. The process produces a microporous shaped part which after sintering leads to a component having a desired density and a desired mechanical and/or thermal stability.

Abstract: The present invention is directed to a method for identifying neural invasion in a pancreatic cancer patient, the method comprising the steps of: determining in a sample of a pancreatic cancer patient the expression level of PlGF and sFlt1; and calculating a ratio of the expression levels of PlGF and sFlt1, wherein the expression level of PlGF forms part either of the numerator or of the denominator of the ratio; characterized in that, a deviation of the ratio of the patient sample from a reference sample or a predetermined threshold value is indicative for presence of neural invasion of the pancreatic cancer in said patient.

Abstract: A system, method and computer program product for detecting indicators for structural changes of NMR active test molecules in a test sample, or indicators for structural changes of the environment of said test molecules in relation to a reference molecule. Initial local similarity values are obtained, using a similarity function and representing a local similarity between a reference spectrum and a test spectrum within corresponding similarity regions (SRR, SRT). The initial local similarity values represent a similarity map (SM1) in which contours of a first shape type are indicators (I1) for structural changes of the test molecule, and in which contours of a second shape type are indicators (I2) for structural changes of the environment of said test molecule in relation to the reference molecule.

Abstract: A method and system for managing engineering of an industrial device in a cloud computing environment is disclosed. The method includes receiving a request for performing an engineering action on at least one of the industrial devices. The method includes determining a control program block corresponding to the at least one of the industrial device based on the received request. Further, segmenting the determined control program block into one or more software units based on content of the control program block. Furthermore, processing the one or more software units based on one or more user requirements and the requested engineering action. Also, determining at least two instances of the industrial device for deploying the processed software units based on segment type of the processed software units. Moreover, deploying the respective software units into each of the determined at least two instances of the industrial device.

Abstract: A throttle for a liquid pipe has at least one liquid duct for a liquid flowing through the throttle, the liquid duct extending along the longitudinal axis of the throttle. The liquid duct has at least one duct wall having a curved shape along the longitudinal axis.

Abstract: The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.

Abstract: A method for dealing with obstacles in an industrial truck, including detecting a current speed and a current steering angle of at least one steered wheel of the industrial truck using a speed sensor or a steering angle sensor. The method also includes calculating a protection zone based on the current speed and the current steering angle and evaluating data supplied by the at least one sensor unit within the protection zone. Responsive to detecting an obstacle in the protection zone, the method includes calculating a specific steering angle difference on a right side and a left side, the specific steering angle difference being such that collision with the obstacle is avoided on the respective side and one or more of, based on the calculated right side and left side steering angle differences, classifying a current degree of difficulty in avoiding obstacles or triggering a predetermined action.

Abstract: Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as arginase inhibitors and can be useful in preventing, treating or acting as a remedial agent for arginase-related diseases.

Abstract: An information encoder for encoding an information signal includes: a converter for converting the linear prediction coefficients of the predictive polynomial A(z) to frequency values f1 . . . fn of a spectral frequency representation of the predictive polynomial A(z), wherein the converter is configured to determine the frequency values f1 . . . fn by analyzing a pair of polynomials P(z) and Q(z) being defined as P ? ( z ) = A ? ( z ) + z - m - l ? A ? ( z - 1 ) ? ? and Q ? ( z ) = A ? ( z ) - z - m - l ? A ? ( z - 1 ) , wherein m is an order of the predictive polynomial A(z) and I is greater or equal to zero, wherein the converter is configured to obtain the frequency values by establishing a strictly real spectrum derived from P(z) and a strictly imaginary spectrum from Q(z) and by identifying zeros of the strictly real spectrum derived from P(z) and the strictly imaginary spectrum derived from Q(z).

Abstract: A flight control system that is adapted for controlling movements of a rotary wing aircraft while considering passenger discomfort, to a rotary wing aircraft with such a flight control system, and to a method of operating a flight control system. The flight control system includes sensors configured to generate sensor data based on captured motions of the rotary wing aircraft, motion actuators that are adapted for inducing a translational and/or a rotational movement of the rotary wing aircraft about at least one of a yaw axis, a roll axis, or a pitch axis, and a passenger discomfort-aware control unit that is configured to generate, based on the sensor data, passenger discomfort-aware actuator control signals for controlling the motion actuators of the rotary wing aircraft.

Abstract: The disclosure relates to compounds and compositions for sustained release of ocular therapeutics.

Abstract: A method for modifying a program of an industrial automation component, wherein the program includes a plurality of program elements, where the program is structured in units, a unit includes a group of program elements and can include both published program elements having an interface that can be referenced by the program elements of other units and unpublished program elements, and where a checksum is calculated and is assigned to the unit using the interfaces, such that if at least one program element of the version of the unit stored in the engineering system is modified, then the modified checksum is compared with the previous checksum version present in the automation component, and only the modified unit is transferred if the checksums match such that consistency of the program is maintained and the software updateable more quickly.

Abstract: The invention relates to a working machine and a method for working the ground with the working machine, having a mast, along which, by means of a positioning means, a rotary head is moved vertically, by which a telescopic Kelly rod having at least two Kelly bars is displaced and guided. According to the invention the Kelly bars are locked or unlocked automatically by means of a control, wherein by means of a first detection means a rotation angle of at least one Kelly bar is detected and/or by means of a second detection means a force, torque or pressure change is detected in a hydraulic system. By the control a locking and/or unlocking of the Kelly bars is determined depending on the detected rotation angle and/or the detected change.

Abstract: The disclosure features surface coatings formed from dimeric steroid prodrugs for the extended delivery of a drug from a surface, and for the treatment of a disease or condition. Also provided herein are drug depots formed from dimeric steroid prodrugs for the extended delivery of a drug for use in combination with implantable medical devices. Said dimeric steroid prodrugs are represented by the formula D1-L-D2, wherein D1 and D2 are independently a steroid radical and L is a linker covalently linking D1 to D2.

Abstract: A front airbag (10) includes an inflatable chamber (18) having a baffle surface (16) provided to cushion an occupant (14) to be restrained, wherein a tether (28) extending inside the inflatable chamber (18) is provided which, when the front airbag (10) is mounted on the vehicle and is inflated, extends obliquely with respect to a vehicle longitudinal direction (L) and which is fastened with a first longitudinal end (34) to a single baffle surface-side fastening point (30) at the baffle surface (16).

Abstract: This invention provides for synthesis of citrulline from a transition metal complex of ornithine using cyanate to derivatize the terminal amino group of ornithine. The invention also provides improved methods for purification of citrulline produced by reaction of cyanate with ornithine via the steps of reprecipitation of copper complex of citrulline, removal of the complexing metal by sulfide precipitation, activated carbon adsorption and antisolvent crystallization.