Patents by Inventor Christian A. Hassig

Christian A. Hassig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REPLICATION STRESS PATHWAY AGENT COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20230272485
    Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.
    Type: Application
    Filed: February 15, 2023
    Publication date: August 31, 2023
    Inventors: Christian HASSIG, Ryan HANSEN, Snezana MILUTINOVIC, Zachary D. HORNBY, Sudhir CHOWDHRY, Kristen TURNER, Deepti WILKINSON, Shailaja KASIBHATLA
  • REPLICATION STRESS PATHWAY AGENT COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20230248728
    Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.
    Type: Application
    Filed: March 24, 2023
    Publication date: August 10, 2023
    Inventors: Christian HASSIG, Ryan HANSEN, Snezana MILUTINOVIC, Jason CHRISTIANSEN, Zachary D. HORNBY, Sudhir CHOWDHRY, Anthony CELESTE, Kristen TURNER, Deepti WILKINSON
  • Replication stress pathway agent compositions and methods for treating cancer
    Patent number: 11642345
    Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.
    Type: Grant
    Filed: October 21, 2022
    Date of Patent: May 9, 2023
    Assignee: BOUNDLESS BIO, INC.
    Inventors: Christian Hassig, Ryan Hansen, Snezana Milutinovic, Jason Christiansen, Zachary Hornby, Sudhir Chowdhry, Anthony Celeste, Kristen Turner, Deepti Wilkinson
  • REPLICATION STRESS PATHWAY AGENT COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20230078903
    Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.
    Type: Application
    Filed: October 21, 2022
    Publication date: March 16, 2023
    Inventors: Christian HASSIG, Ryan HANSEN, Snezana MILUTINOVIC, Jason CHRISTIANSEN, Zachary HORNBY, Sudhir CHOWDHRY, Anthony CELESTE, Kristen TURNER, Deepti WILKINSON
  • Replication stress pathway agent compositions and methods for treating cancer
    Patent number: 11547711
    Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.
    Type: Grant
    Filed: January 4, 2022
    Date of Patent: January 10, 2023
    Assignee: BOUNDLESS BIO, INC.
    Inventors: Christian Hassig, Ryan Hansen, Snezana Milutinovic, Jason Christiansen, Zachary Hornby, Sudhir Chowdhry, Anthony Celeste, Kristen Turner, Deepti Wilkinson
  • REPLICATION STRESS PATHWAY AGENT COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20220143022
    Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.
    Type: Application
    Filed: January 4, 2022
    Publication date: May 12, 2022
    Inventors: Christian HASSIG, Ryan HANSEN, Snezana MILUTINOVIC, Jason CHRISTIANSEN, Zachary HORNBY, Sudhir CHOWDHRY, Anthony CELESTE, Kristen TURNER, Deepti WILKINSON
  • Quinolinones as inhibitors of translation initiation complex
    Patent number: 10577349
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising quinolinones. The quinolinones and compositions thereof are useful as eukaryotic translation initiation factor 4F (eIF4F) complex modulators.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: March 3, 2020
    Assignees: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Ze'ev Ronai, Anthony B. Pinkerton, Yongmei Feng, Ivan Topisirovic, Kevin Brown, Christian A. Hassig
  • Inhibitors of glucocorticoid receptor translocation
    Patent number: 10272074
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of Glucocorticoid Receptor (GR) translocation. Furthermore, the subject compounds and compositions are useful for the treatment of diseases involved in the hypothalamic-pituitary-adrenal (HPA) axis.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: April 30, 2019
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Anthony B. Pinkerton, Christian A. Hassig, Michael R. Jackson, Robert John Ardecky, Ian Pass
  • Pyrazolopyrimidines as Inhibitors of Glucocorticoid Receptor Translocation
    Publication number: 20180207140
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of Glucocorticoid Receptor (GR) translocation. Furthermore, the subject compounds and compositions are useful for the treatment of diseases involved in the hypothalamic-pituitary-adrenal (HPA) axis.
    Type: Application
    Filed: January 28, 2016
    Publication date: July 26, 2018
    Inventors: Anthony B. PINKERTON, Christian A. HASSIG, Michael R. JACKSON, Robert John ARDECKY, Ian PASS
  • Quinolinones as Inhibitors of Translation Initiation Complex
    Publication number: 20180044324
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising quinolinones. The quinolinones and compositions thereof are useful as eukaryotic translation initiation factor 4F (eIF4F) complex modulators.
    Type: Application
    Filed: March 1, 2016
    Publication date: February 15, 2018
    Inventors: Ze'ev RONAI, Anthony B. PINKERTON, Yongmei FENG, Ivan TOPISIROVIC, Kevin BROWN, Christian A. HASSIG
  • Class II human histone deacetylases, and uses related thereto
    Patent number: 8895284
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: November 25, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber
  • CLASS II HUMAN HISTONE DEACETYLASES, AND USES RELATED THERETO
    Publication number: 20130338024
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Application
    Filed: May 7, 2013
    Publication date: December 19, 2013
    Applicant: President and Fellows of Harvard College
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber
  • Class II human histone deacetylases, and uses related thereto
    Patent number: 8435780
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: May 7, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber
  • Histone deacetylases, and uses related thereto
    Patent number: 8426592
    Abstract: The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: April 23, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: Stuart L. Schreiber, Jack Taunton, Christian A. Hassig, Timothy F. Jamison
  • Histone deacetylases, and uses related thereto
    Patent number: 8399233
    Abstract: The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: March 19, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: Stuart L. Schreiber, Jack Taunton, Christian A. Hassig, Timothy F. Jamison
  • Histone deacetylases, and uses related thereto
    Patent number: 8362084
    Abstract: The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: January 29, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: Stuart L. Schreiber, Jack Taunton, Christian A. Hassig, Timothy F. Jamison
  • Histone deacetylases, and uses related thereto
    Patent number: 8329945
    Abstract: The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: December 11, 2012
    Assignee: President and Fellows of Harvard College
    Inventors: Stuart L. Schreiber, Jack Taunton, Christian A. Hassig, Timothy F. Jamison
  • Histone deacetylases, and uses related thereto
    Patent number: 8329946
    Abstract: The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: December 11, 2012
    Assignee: President and Fellows of Harvard College
    Inventors: Stuart L. Schreiber, Jack Taunton, Christian A. Hassig, Timothy F. Jamison
  • HISTONE DEACETYLASES, AND USES RELATED THERETO
    Publication number: 20120302510
    Abstract: The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
    Type: Application
    Filed: August 3, 2012
    Publication date: November 29, 2012
    Applicant: President and Fellows of Harvard College
    Inventors: Stuart L. Schreiber, Jack Taunton, Christian A. Hassig, Timothy F. Jamison
  • CLASS II HUMAN HISTONE DEACETYLASES, AND USES RELATED THERETO
    Publication number: 20120094862
    Abstract: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.
    Type: Application
    Filed: December 13, 2011
    Publication date: April 19, 2012
    Applicant: President and Fellows of Harvard College
    Inventors: Christina M. Grozinger, Christian A. Hassig, Stuart L. Schreiber