Abstract: Binding proteins comprising a VL region paired with a VH region, and a CH1 region paired with a CL region, wherein the VL region and VH region comprise opposite charged mutations to facilitate pairing, and wherein the CH1 region and CL region comprise mutations to facilitate pairing, are provided. Binding proteins comprising one or more cysteine residues engineered into the VH/VL pair to form one or more disulfide bonds, are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Abstract: Reamer instruments and related methods are disclosed for use in preparing bone, such as a glenoid bone surface, to receive an implant requiring one of two or more possible surface geometries. Described reamer instruments can have a modular or multi-component design. A minimal number of components can be particular to a particular required geometry, which can allow assembly and use of reamer instruments of the present disclosure to be flexible, intuitive, and efficient. In some embodiments, a disposable reamer head assembly can be driven by a disposable drive tip through a pin-on-pin connection. The remaining components of the reamer instrument can be sterilized and re-used. To prepare bone for a half-wedge implant, a half-wedge housing can be coupled to a reamer instrument handle and a depth stop can be coupled to the housing to achieve the required geometry. Alternatively, a full-wedge housing can be coupled to the instrument handle.

Abstract: Reamer instruments and related methods are disclosed for use in preparing bone, such as a glenoid bone surface, to receive an implant requiring one of two or more possible surface geometries. Described reamer instruments can have a modular or multi-component design. A minimal number of components can be particular to a particular required geometry, which can allow assembly and use of reamer instruments of the present disclosure to be flexible, intuitive, and efficient. In some embodiments, a disposable reamer head assembly can be driven by a disposable drive tip through a pin-on-pin connection. The remaining components of the reamer instrument can be sterilized and re-used. To prepare bone for a half-wedge implant, a half-wedge housing can be coupled to a reamer instrument handle and a depth stop can be coupled to the housing to achieve the required geometry. Alternatively, a full-wedge housing can be coupled to the instrument handle.