Patents by Inventor Christian Andrea Di Buduo

Christian Andrea Di Buduo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SILK FIBROIN BIOINKS AND RELATED USE FOR 3D BIOPRINTING
    Publication number: 20240131220
    Abstract: The present invention relates to silk fibroin bioinks specifically formulated for use in 3D bioprinting and the production of ex-vivo models capable of supporting hematopoiesis and the production of platelets and blood cells.
    Type: Application
    Filed: February 24, 2022
    Publication date: April 25, 2024
    Inventors: Alessandra BALDUINI, Christian Andrea DI BUDUO, Pierre-Alexandre LAURENT, Erik GATENHOLM, Hector MARTINEZ, Itedale REDWAN-NAMRO, Volodymyr KUZMENKO
  • Microphysiologic methods and compositions
    Patent number: 11802270
    Abstract: The present invention provides, among other things, methods for producing platelets including the steps of providing a silk membrane about 2 ?m and 100 ?m thick, inclusive, contacting the silk membrane with a porogen to form a porous silk membrane comprising at least one silk wall defining a lumen, associating the porous silk membrane with stromal derived factor-1? and at least one functionalizing agent, forming a three dimensional silk matrix comprising interconnected pores wherein the pores have a diameter of between about 5 and 500 ?m, inclusive, wherein the silk matrix is formed around at least a portion of the porous silk membrane, introducing a plurality of megakaryocytes to the silk matrix such that the megakaryocytes are located at least partially within the porous silk matrix, and stimulating the plurality of megakaryocytes to produce platelets. Also provided are various new compositions and methods of making those compositions.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: October 31, 2023
    Assignees: Tufts University, University of Pavia
    Inventors: Alessandra Balduini, David L. Kaplan, Lindsay Wray, Christian Andrea Di Buduo, Lorenzo Tozzi
  • MICROPHYSIOLOGIC METHODS AND COMPOSITIONS
    Publication number: 20170218339
    Abstract: The present invention provides, among other things, methods for producing platelets including the steps of providing a silk membrane about 2 ?m and 100 ?m thick, inclusive, contacting the silk membrane with a porogen to form a porous silk membrane comprising at least one silk wall defining a lumen, associating the porous silk membrane with stromal derived factor-1? and at least one functionalizing agent, forming a three dimensional silk matrix comprising interconnected pores wherein the pores have a diameter of between about 5 and 500 ?m, inclusive, wherein the silk matrix is formed around at least a portion of the porous silk membrane, introducing a plurality of megakaryocytes to the silk matrix such that the megakaryocytes are located at least partially within the porous silk matrix, and stimulating the plurality of megakaryocytes to produce platelets. Also provided are various new compositions and methods of making those compositions.
    Type: Application
    Filed: August 6, 2015
    Publication date: August 3, 2017
    Inventors: Alessandra Balduini, David L. Kaplan, Lindsay Wray, Christian Andrea Di Buduo, Lorenzo Tozzi, Ying Chen