Patents by Inventor Christian Andreas KUTTRUFF

Christian Andreas KUTTRUFF has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS
    Publication number: 20240342186
    Abstract: The invention relates to new proline derivatives of formula (I) as cGAS inhibitors, wherein wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and G are defined as in claim 1, and prodrugs or pharmaceutically acceptable salts of these compounds for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), non-alcoholic steatotic hepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).
    Type: Application
    Filed: June 5, 2024
    Publication date: October 17, 2024
    Inventors: Annekatrin Charlotte HEIMANN, Sandra Ruth HANDSCHUH, Christoph HOENKE, Cédrickx GODBOUT, Christian GNAMM, Patrick GROSS, Marc Alexander GRUNDL, Joerg Thomas KLEY, Christian Andreas KUTTRUFF, Dirk REINART, Raphael STUBER, Theodor THEIS
  • [1,3]Thiazolo[4,5-d]-pyrimidon-7-ones as inhibitors of NOX4
    Publication number: 20240327429
    Abstract: The present disclosure provides [1,3]thiazolo[4,5-d]-pyrimidon-7-ones that are inhibitors of NOX4, and are therefore useful for the treatment of diseases treatable by inhibition of NOX4. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: February 27, 2024
    Publication date: October 3, 2024
    Inventors: Christian GNAMM, Elmar BAUSCHATZ, Frank BUETTNER, Cédrickx GODBOUT, Annekatrin Charlotte HEIMANN, Christoph HOENKE, Ferenc KONTES, Christian Andreas KUTTRUFF, Dieter WIEDENMAYER, Raphael WILDERMUTH
  • Pyridine derivatives with c-linked cyclic substituents as cGAS inhibitors
    Patent number: 12043625
    Abstract: The invention relates to new proline derivatives of formula (I) as cGAS inhibitors, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and G are defined as in claim 1, and prodrugs or pharmaceutically acceptable salts of these compounds for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), non-alcoholic steatotic hepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).
    Type: Grant
    Filed: May 10, 2022
    Date of Patent: July 23, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Annekatrin Charlotte Heimann, Sandra Ruth Handschuh, Christoph Hoenke, Christian Gnamm, Cédrickx Godbout, Patrick Gross, Joerg Kley, Christian Andreas Kuttruff, Dirk Reinert, Raphael Stuber, Marc Grundl, Theodor Theis
  • CYCLIC BENZIMIDAZOLE DERIVATIVES AS CGAS INHIBITORS
    Publication number: 20240208997
    Abstract: The invention relates to compounds of formula I wherein R1, R2, R3, A, D, E, G, J, K and L are defined as in claim 1, and prodrugs, deuterated analogues and pharmaceutical acceptable salts thereof, for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), interferonopathies, non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).
    Type: Application
    Filed: November 3, 2023
    Publication date: June 27, 2024
    Inventors: Annekatrin Charlotte HEIMANN, Alexander DREYER, Christian GNAMM, Cédrickx GODBOUT, Marc Alexander GRUNDL, Sandra Ruth HANDSCHUH, Christoph HOENKE, Joerg Thomas KLEY, Christian Andreas KUTTRUFF, Jun LI, Dirk REINERT, Raphael STUBER
  • Cyclic Pyridine Derivatives as cGAS Inhibitors
    Publication number: 20240189315
    Abstract: The invention relates to compounds of formula I wherein R1, R2, R3, R4, A, D, E, G, J, K and L are defined as in claim 1, and prodrugs, deuterated analogues and pharmaceutical acceptable salts thereof, for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), interferonopathies, non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).
    Type: Application
    Filed: November 3, 2023
    Publication date: June 13, 2024
    Inventors: Annekatrin Charlotte HEIMANN, Christian GNAMM, Cédrickx GODBOUT, Sandra Ruth HANDSCHUH, Christoph HOENKE, Joerg Thomas KLEY, Christian Andreas KUTTRUFF, Jun LI, Dirk REINERT, Raphael STUBER, Theodor THEIS
  • PYRIDAZINES
    Publication number: 20230100516
    Abstract: The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by Autotaxin.
    Type: Application
    Filed: September 23, 2022
    Publication date: March 30, 2023
    Inventors: Christian Andreas Kuttruff, Tom Bretschneider, Cédrickx Godbout, Hannes Fiepko Koolman, Domnic Martyres, Gerald Juergen Roth
  • NOVEL PYRIDAZINES
    Publication number: 20230022770
    Abstract: The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by Autotaxin.
    Type: Application
    Filed: August 30, 2022
    Publication date: January 26, 2023
    Inventors: Christian Andreas KUTTRUFF, Tom BRETSCHNEIDER, Cédrickx GODBOUT, Hannes Fiepko KOOLMAN, Domnic MARTYRES, Gerald Juergen ROTH
  • PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS
    Publication number: 20230000878
    Abstract: The invention relates to new proline derivatives of formula (I) as cGAS inhibitors, wherein wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and G are defined as in claim 1, and prodrugs or pharmaceutically acceptable salts of these compounds for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), non-alcoholic steatotic hepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).
    Type: Application
    Filed: May 10, 2022
    Publication date: January 5, 2023
    Inventors: Annekatrin Charlotte HEIMANN, Sandra Ruth HANDSCHUH, Christoph HOENKE, Cédrickx GODBOUT, Christian GNAMM, Patrick GROSS, Joerg KLEY, Christian Andreas KUTTRUFF, Dirk REINERT, Raphael STUBER
  • PYRIDINE DERIVATIVES WITH C-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS
    Publication number: 20230002401
    Abstract: The invention relates to new proline derivatives of formula (I) as cGAS inhibitors, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and G are defined as in claim 1, and prodrugs or pharmaceutically acceptable salts of these compounds for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), non-alcoholic steatotic hepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).
    Type: Application
    Filed: May 10, 2022
    Publication date: January 5, 2023
    Inventors: Annekatrin Charlotte HEIMANN, Sandra Ruth HANDSCHUH, Christoph HOENKE, Christian GNAMM, Cédrickx GODBOUT, Patrick GROSS, Joerg KLEY, Christian Andreas KUTTRUFF, Dirk REINERT, Raphael STUBER
  • N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators
    Patent number: 11485727
    Abstract: The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by autotaxin.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: November 1, 2022
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Christian Andreas Kuttruff, Tom Bretschneider, Cédrickx Godbout, Hannes Fiepko Koolman, Domnic Martyres, Gerald Juergen Roth
  • Pyridazines
    Patent number: 11465982
    Abstract: The present invention relates to novel pyridazines of the below formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by autotaxin:
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: October 11, 2022
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Christian Andreas Kuttruff, Tom Bretschneider, Cédrickx Godbout, Hannes Fiepko Koolman, Domnic Martyres, Gerald Juergen Roth
  • N-METHYL, N-(6-(METHOXY)PYRIDAZIN-3-YL) AMINE DERIVATIVES AS AUTOTAXIN (ATX) MODULATORS FOR THETREATMENT OF INFLAMMATORY AIRWAY OR FIBROTIC DISEASES
    Publication number: 20220281838
    Abstract: The present invention relates to N-methyl, N-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases such as e.g. idiopathic lung disease (IFF) or systemic sclerosis (SSc). The present description discloses the preparation of exemplary compounds (e.g. pages 37 to 45; examples 1.1 to 1.13) as well as relevant biological data thereof (e.g. pages 12 to 17, tables 1 to 9). An exemplary compound is e.g. 1-[4-(4-{1-[(6-{[6-(trifluoromethyl) pyridin-3-yl]methoxy}pyridazin-3-yl)amino]cyclopropyl}-phenyl) piperazin-1-yl]ethan-1-one (example 1.1).
    Type: Application
    Filed: July 21, 2020
    Publication date: September 8, 2022
    Inventors: Christian Andreas KUTTRUFF, Cedrickx GODBOUT, Hannes Fiepko KOOLMAN, Gerald Juergen ROTH
  • Pyridazines
    Patent number: 11104665
    Abstract: The present invention relates to novel pyridazines according to formula (I) processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by Autotaxin.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: August 31, 2021
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Gerald Juergen Roth, Tom Bretschneider, Christian Andreas Kuttruff
  • NOVEL PYRIDAZINES
    Publication number: 20210024495
    Abstract: The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by Autotaxin.
    Type: Application
    Filed: July 20, 2020
    Publication date: January 28, 2021
    Inventors: Christian Andreas KUTTRUFF, Tom BRETSCHNEIDER, Cédrickx GODBOUT, Hannes Fiepko KOOLMAN, Domnic MARTYRES, Gerald Juergen ROTH
  • NOVEL PYRIDAZINES
    Publication number: 20210024492
    Abstract: The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by Autotaxin.
    Type: Application
    Filed: July 20, 2020
    Publication date: January 28, 2021
    Inventors: Christian Andreas KUTTRUFF, Tom BRETSCHNEIDER, Cédrickx GODBOUT, Hannes Fiepko KOOLMAN, Domnic MARTYRES, Gerald Juergen ROTH
  • MODIFIED CYCLIC DINUCLEOTIDE COMPOUNDS
    Publication number: 20210024567
    Abstract: Compounds of formula (I) wherein Base, R1 and R2 are defined as in claim 1, are modulators of STING.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 28, 2021
    Inventors: Thorsten OOST, Martin FLECK, Christian Andreas KUTTRUFF
  • CYCLIC DINUCLEOTIDE COMPOUNDS CONTAINING 2-AZA-HYPOXANTHINE OR 6H-PYTAZOLO[1,5-D][1,2,4]TRIZAIN-7-ONE AS STRING AGONISTS
    Publication number: 20210009627
    Abstract: Compounds of formula I, wherein Base, R1 and R2 are defined as in claim 1, are modulators of STING.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 14, 2021
    Inventors: Annekatrin Charlotte HEIMANN, Martin FLECK, Christian Andreas KUTTRUFF, Thorsten OOST
  • NOVEL PYRIDAZINES
    Publication number: 20200131151
    Abstract: The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by Autotaxin.
    Type: Application
    Filed: October 25, 2019
    Publication date: April 30, 2020
    Inventors: Gerald Juergen ROTH, Tom BRETSCHNEIDER, Christian Andreas KUTTRUFF
  • Modified cyclic dinucleotide compounds
    Patent number: 10392419
    Abstract: Compounds of formula (I) wherein Base1 and Base2 are defined as in claim 1 are modulators of STING.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: August 27, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thorsten Oost, Martin Fleck, Christian Andreas Kuttruff, Sebastian Carotta
  • MODIFIED CYCLIC DINUCLEOTIDE COMPOUNDS
    Publication number: 20180273578
    Abstract: Compounds of formula (I) wherein Base1 and Base2 are defined as in claim 1 are modulators of STING.
    Type: Application
    Filed: March 20, 2018
    Publication date: September 27, 2018
    Inventors: Thorsten OOST, Martin FLECK, Christian Andreas KUTTRUFF, Sebastian CAROTTA