Patents by Inventor Christian Auclair

Christian Auclair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhancement of cancer treatment efficiency via the sphingosine-1-phosphate pathway
    Patent number: 11850234
    Abstract: The use of a neoadjuvant prior to chemotherapy. A sphingosine-1-phosphate pathway activator for use in the treatment of cancer as a neoadjuvant prior to chemotherapy selected from sphingosine-1-phosphate lyase inhibitors. The sphingosine-1-phosphate pathway activator enhances the chemotherapy efficiency through the normalization of intratumoral vascular network, promoting the effects of the sequential administration of an anticancer agent or a sequential radiotherapy.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: December 26, 2023
    Assignee: AC BIOSCIENCE
    Inventor: Christian Auclair
  • Immunomodulatory Compounds And Use Thereof For The Treatment And/Or Prevention Of Infectious Diseases
    Publication number: 20230355749
    Abstract: The invention provides immunomodulatory compounds, adjuvant compositions comprising thereof, immunogenic compositions comprising thereof and uses of immunomodulatory compounds as adjuvants in vaccination, for increasing the immune response via the improvement of maturation and activation of dendritic cells, and for the treatment and/or prevention of infectious diseases, cancer and autoimmune diseases.
    Type: Application
    Filed: September 22, 2021
    Publication date: November 9, 2023
    Inventors: Christian AUCLAIR, Annette IVES
  • A COMBINATION OF FLAVONOIDS AND SPHINGOSINE 1 PHOSPHATE LYASE INHIBITORS FOR THE TREATMENT OF LUNG INFLAMMATION
    Publication number: 20230121797
    Abstract: The invention provides a pharmaceutical combination of a flavonoid compound and a sphingosine-1-phosphate lyase inhibitor (S1PLI) for simultaneous, separate or sequential administration, and use thereof for ameliorating and/or reducing the lung inflammation, resulting from MERS-CoV and/or SARS-CoV virus infection, during and following the virus infection.
    Type: Application
    Filed: March 25, 2021
    Publication date: April 20, 2023
    Inventors: Christian AUCLAIR, Annette IVES
  • COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF INFECTIOUS DISEASES AND CANCER
    Publication number: 20220306587
    Abstract: The invention provides the imidazole, oxazole and thiazole compounds and use thereof in methods for treating a disease or a disorder, such as infectious diseases and cancer, wherein inhibition of sphingosine-1-phosphate lyase is beneficial to treat the disease or the disorder.
    Type: Application
    Filed: August 20, 2020
    Publication date: September 29, 2022
    Inventors: Christian AUCLAIR, Annette IVES
  • COMPOSITION AND USE THEREOF FOR THE TREATMENT OF CUTANEOUS MASTOCYTOSIS
    Publication number: 20220265670
    Abstract: The invention provides topical pharmaceutical compositions and use thereof for treating or lessening the symptoms of, or preventing the symptoms of cutaneous mastocytosis.
    Type: Application
    Filed: May 22, 2020
    Publication date: August 25, 2022
    Inventor: Christian AUCLAIR
  • Topical compositions for the treatment of cutaneous leishmaniasis
    Patent number: 11351146
    Abstract: The present invention relates to a composition comprising a combination of a (halogenoacetamido)benzoate, a flavonol and a terpene, and, as example, relates to a composition comprising the combination of ethyl 3-(2-chloroacetamido)benzoate, dihydroquercetin and bisabolol. Said composition is for use in the treatment of leishmaniasis, especially cutaneous or mucosal leishmaniasis, the composition being applied topically for concomitantly treating both parasitic infection and skin inflammation of the infected area induced by leishmaniasis.
    Type: Grant
    Filed: September 3, 2018
    Date of Patent: June 7, 2022
    Inventors: Christian Auclair, Esther Fellous, Patrice Le Pape, Jorge E. Kalil-Filho
  • Beta-Carboline Compounds And Use Thereof For The Non-Cytotoxic And Immunological Treatment Of Cancer
    Publication number: 20220142994
    Abstract: The invention provides a ?-carboline compound (an indole-containing compound) able to induce actin network remodeling in cancer cells into actin organized network and use thereof in non-cytotoxic cancer immunotherapy, for enhancing immune checkpoint inhibitor therapy, for activating cancer immune response, for treating or lessening the symptoms of, or preventing the human cancer, alone or in combination with one or more cancer immunotherapeutic agent for simultaneous, separate or sequential administration.
    Type: Application
    Filed: March 24, 2020
    Publication date: May 12, 2022
    Inventor: Christian AUCLAIR
  • Compositions comprising dihydroquercetin for use in methods for treating herpes
    Patent number: 11077087
    Abstract: Disclosed is the use of a composition including dihydroquercetin and optionally ?-tocopherol and/or bisabolol for treating herpes infection. Also disclosed is the use of such a composition for treating inflammation induced by herpes infection in mucosa, as well as a method for treating HSV infection and the associated inflammation.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: August 3, 2021
    Assignee: BIONOOX SUISSE SA
    Inventor: Christian Auclair
  • Compositions For Treating And/Or Preventing Photodynamic Therapy Side Effects
    Publication number: 20210113523
    Abstract: The present invention relates to a composition combination for treating and/or preventing Photodynamic therapy side effects.
    Type: Application
    Filed: January 30, 2019
    Publication date: April 22, 2021
    Inventor: Christian AUCLAIR
  • Composition And Use Thereof Against Drugs Induced Phototoxicity
    Publication number: 20210113518
    Abstract: The invention provides the pharmaceutical composition and use thereof for treating or lessening the symptoms of, or preventing the symptoms of drug-induced phototoxicity or photosensitivity.
    Type: Application
    Filed: January 30, 2019
    Publication date: April 22, 2021
    Inventor: Christian AUCLAIR
  • TOPICAL COMPOSITIONS FOR THE TREATMENT OF CUTANEOUS LEISHMANIASIS
    Publication number: 20210059979
    Abstract: The present invention relates to a composition comprising a combination of a (halogenoacetamido)benzoate, a flavonol and a terpene, and, as example, relates to a composition comprising the combination of ethyl 3-(2-chloroacetamido)benzoate, dihydroquercetin and bisabolol. Said composition is for use in the treatment of leishmaniasis, especially cutaneous or mucosal leishmaniasis, the composition being applied topically for concomitantly treating both parasitic infection and skin inflammation of the infected area induced by leishmaniasis.
    Type: Application
    Filed: September 3, 2018
    Publication date: March 4, 2021
    Inventors: Christian Auclair, Esther Fellous, Patrice Le Pape, Jorge E. Kalil-Filho
  • ENHANCEMENT OF CANCER TREATMENT EFFICIENCY VIA THE SPHINGOSINE-1-PHOSPHATE PATHWAY
    Publication number: 20200261420
    Abstract: The use of a neoadjuvant prior to chemotherapy. A sphingosine-1-phosphate pathway activator for use in the treatment of cancer as a neoadjuvant prior to chemotherapy selected from sphingosine-1-phosphate lyase inhibitors. The sphingosine-1-phosphate pathway activator enhances the chemotherapy efficiency through the normalization of intratumoral vascular network, promoting the effects of the sequential administration of an anticancer agent or a sequential radiotherapy.
    Type: Application
    Filed: August 17, 2018
    Publication date: August 20, 2020
    Applicant: AC BIOSCIENCE
    Inventor: Christian AUCLAIR
  • Human mast cell lines, preparation and uses
    Patent number: 10383955
    Abstract: The present invention relates to a human mast cell line corresponding to deposit number CNCM I-4551 and also to the lines derived therefrom, in particular the derived lines corresponding respectively to deposit numbers CNCM I-4552 and CNCM I-4553, and to the uses thereof, in particular for screening for compounds of therapeutic interest.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: August 20, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE CACHAN, MEDIZINISCHE UNIVERSITAT WIEN
    Inventors: Michel Arock, Peter Valent, Rosine Saleh, Ghaith Wedeh, Christian Auclair
  • Compositions comprising dihydroquercetin for use in methods for treating the effects associated with skin inflammatory disorders
    Patent number: 9956200
    Abstract: A method of using a composition including dihydroquercetin, as well as optionally ?-tocopherol and/or bisabolol, for treating the effects associated with skin inflammatory disorder, such as those associated with diseases characterized by inappropriate immune response, such as psoriasis, atopic dermatitis and/or urticaria. A process of manufacturing the composition is also described.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: May 1, 2018
    Assignee: BIONOOX SUISSE SA
    Inventor: Christian Auclair
  • COMPOSITIONS COMPRISING DIHYDROQUERCETIN FOR USE IN METHODS FOR TREATING HERPES
    Publication number: 20180055815
    Abstract: Disclosed is the use of a composition including dihydroquercetin and optionally ?-tocopherol and/or bisabolol for treating herpes infection. Also disclosed is the use of such a composition for treating inflammation induced by herpes infection in mucosa, as well as a method for treating HSV infection and the associated inflammation.
    Type: Application
    Filed: March 18, 2016
    Publication date: March 1, 2018
    Inventor: Christian AUCLAIR
  • COMPOSITIONS COMPRISING DIHYDROQUERCETIN FOR USE IN METHODS FOR TREATING THE EFFECTS ASSOCIATED WITH SKIN INFLAMMATORY DISORDERS
    Publication number: 20170246141
    Abstract: A method of using a composition including dihydroquercetin, as well as optionally ?-tocopherol and/or bisabolol, for treating the effects associated with skin inflammatory disorder, such as those associated with diseases characterized by inappropriate immune response, such as psoriasis, atopic dermatitis and/or urticaria. A process of manufacturing the composition is also described.
    Type: Application
    Filed: February 18, 2015
    Publication date: August 31, 2017
    Inventor: Christian AUCLAIR
  • Companion cosmetic compositions
    Patent number: 9271956
    Abstract: A composition includes dihydroquercetin, ?-tocopherol and bisabolol. The use of the composition in a cosmetic method for limiting, alleviating and/or preventing cutaneous discomfort, especially cutaneous discomfort induced by a disease or induced by a therapy, a radiotherapy treatment and/or chemotherapy treatment, and the process of manufacturing the composition are also described.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: March 1, 2016
    Assignee: BIONOOX SUISSE SA
    Inventor: Christian Auclair
  • COMPANION COSMETIC COMPOSITIONS
    Publication number: 20150238459
    Abstract: A composition includes dihydroquercetin, ?-tocopherol and bisabolol. The use of the composition in a cosmetic method for limiting, alleviating and/or preventing cutaneous discomfort, especially cutaneous discomfort induced by a disease or induced by a therapy, a radiotherapy treatment and/or chemotherapy treatment, and the process of manufacturing the composition are also described.
    Type: Application
    Filed: August 20, 2013
    Publication date: August 27, 2015
    Inventor: Christian Auclair
  • HUMAN MAST CELL LINES, PREPARATION AND USES
    Publication number: 20140298497
    Abstract: The present invention relates to a human mast cell line corresponding to deposit number CNCM I-4551 and also to the lines derived therefrom, in particular the derived lines corresponding respectively to deposit numbers CNCM I-4552 and CNCM I-4553, and to the uses thereof, in particular for screening for compounds of therapeutic interest.
    Type: Application
    Filed: November 2, 2012
    Publication date: October 2, 2014
    Inventors: Michel Arock, Peter Valent, Rosine Saleh, Ghaith Wedeh, Christian Auclair
  • Gene transfer vectors comprising genetic insulator elements and methods to identify genetic insulator elements
    Patent number: 8828718
    Abstract: The present invention relates to a gene transfer vector (GTV) and in particular to an integrating gene transfer vector (IGTV), which comprises at least one genetic insulator element (GIE), wherein the each comprises at least two copies of an element selected from the group consisting of: a CTF binding site; a first CTCF binding site and a second CTCF binding site, wherein the first and the second CTCF binding sites are derived from the regulatory sequences of different genes.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: September 9, 2014
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Odile Cohen-Haguenauer, Christian Auclair