Abstract: The present invention relates to an imaging sensor system (26) having a high detection accuracy. The system (26) comprises a plurality of pixel sensors (1) and at least one light source. The pixel sensors (1) are grouped in clusters, wherein each pixel sensor (1) comprises a photodetector (2) and a local controlling circuit (18). The plurality of sensors (1) in each cluster are configured, using local controlling circuits (18), to output a global detection signal (15) when detecting a local detection signal (10) from at least two outputs of the photodetectors (2) of said cluster. The system (26) has a high detection accuracy due to ruling out false positive detections, since each detection requires at least two positive outputs of the photodetectors (2) of said cluster.

Abstract: A dialysis system is disclosed that enables a patient to undergo both peritoneal dialysis and extracorporeal blood treatments. The system includes a base unit and a blood treatment unit configured to perform extracorporeal blood treatments on a patient. The blood treatment unit includes a user interface operable with a controller for displaying a calendar of days in which an extracorporeal blood treatment is scheduled to be performed. The base unit includes a base unit controller that is programmed to receive information indicative whether a peritoneal dialysis treatment or the extracorporeal blood treatment is to be performed. The base unit controller operates first software instructions when the base unit uses a first fluid stored in a fluid container when the peritoneal dialysis treatment is selected or operates second software instructions when the base unit uses a second, different fluid from an online source when the extracorporeal blood treatment is selected.

Abstract: A method of treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), otherwise known as COVID-19, infection by administering nicotinic receptor antagonists and/or PPAR-? agonists is presented. A combination of mecamylamine, or an isomer thereof, and pioglitazone synergistically reduces replication of SARS-CoV-2 in virus-infected cells and also synergistically reduces inflammatory cytokines such as IL-6, IL-?, and TNF?, which have been associated with SARS-CoV-2 infection.

Abstract: A dialysis method to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments is disclosed. The method includes determining, via a base unit controller, whether a peritoneal dialysis treatment or an extracorporeal blood treatment is to be performed. If the peritoneal dialysis treatment is to be performed, the method includes operating first software instructions that cause a base unit to use a first fluid stored in a fluid container. If the extracorporeal blood treatment is to be performed, the method includes operating second software instructions that cause the base unit to use a second, different fluid from an online source and selectively move the second, different fluid to a blood treatment unit for use in the extracorporeal blood treatment. The blood treatment unit is operable with the base unit to perform the extracorporeal blood treatment on a patient.

Abstract: A dialysis method to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments is disclosed. The method includes determining, via a base unit controller, whether a peritoneal dialysis treatment or an extracorporeal blood treatment is to be performed. If the peritoneal dialysis treatment is to be performed, the method includes operating first software instructions that cause a base unit to use a first fluid stored in a fluid container. If the extracorporeal blood treatment is to be performed, the method includes operating second software instructions that cause the base unit to use a second, different fluid from an online source and selectively move the second, different fluid to a blood treatment unit for use in the extracorporeal blood treatment. The blood treatment unit is operable with the base unit to perform the extracorporeal blood treatment on a patient.

Abstract: A dialysis system is configured to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments. The example dialysis system includes a base unit configurable to provide a first fluid for use in preforming at least one peritoneal dialysis treatment at a first time. The base unit is further configurable to provide a second, different fluid for use in at least one extracorporeal blood treatment at a second, different time. The example dialysis system also includes a blood treatment unit configured to be docked to the base unit. The blood treatment unit includes a blood pump configured to pump blood from the patient to a blood filter and from the blood filter back to the patient. The blood filter or a blood line in communication with the blood filter receives the second fluid from the base unit for use in the at least one extracorporeal blood treatment.

Abstract: A direct memory access controller, configured to be used in a computing node of a system on chip (SoC), includes: (1) an input buffer for receiving packets of data coming from an input/output interface of the computing node; (2) a write control module for controlling writing of data extracted from each packet to a local memory of the computing node shared by at least one processor other than the direct memory access controller; and (3) an arithmetic logic unit for executing microprograms. The write control module is configured to control the execution by the arithmetic logic unit of at least one microprogram including instruction lines for arithmetic and/or logical calculation concerning only storage addresses for storing the data received by the input buffer for a reorganization of the data in the shared local memory. Optionally, at least one microprogram may be stored in a register, and at least two operating modes (e.g.

Abstract: A cache coherence management system includes: a set of directories distributed between nodes of a network for interconnecting processors including cache memories, each directory including a correspondence table between cache lines and information fields on the cache lines; and a mechanism updating the directories by adding, modifying, or deleting cache lines in the correspondence tables. In each correspondence table and for each cache line identified, at least one field is provided for indicating a possible blocking of a transaction relative to the cache line considered, when the blocking occurs in the node associated with the correspondence table considered. The system further includes a mechanism detecting fields indicating a transaction blocking and restarting each transaction detected as blocked from the node in which it is indicated as blocked.

Abstract: A topology-based triage workflow service can display expert generated workflows in conjunction with a topology. A user can select a device experiencing an issue and can walk through a workflow for diagnosing an issue. The service analyzes the workflow to determine which components are related to each troubleshooting step and can highlight them within the topology to indicate to a user the relevant components. The service can also retrieve and display metrics relevant to each step in the workflow. As workflows are used, the service can track users' paths through workflows, troubleshooting success, and feedback. Based on the feedback, the application can improve workflows, suggest root causes of issues, or create automated scripts based on the most popular/successful workflows for solving particular issues.

Abstract: A hybrid hemodialysis (“HD”)/peritoneal dialysis (“PD”) system includes: a reservoir; a weigh scale operably coupled with the reservoir; and at least one controller programmed to run (i) an HD treatment in which blood is pumped to a blood compartment of a dialyzer, fresh HD dialysis fluid is pumped to a dialysis fluid compartment of the dialyzer, and used HD dialysis fluid is pumped from the dialysis fluid compartment of the dialyzer to the reservoir, and at a different time (ii) a PD treatment in which fresh PD dialysis fluid is pumped to a patient and used PD dialysis fluid is pumped from the patient to the reservoir.

Abstract: A dialysis system includes a fluid line fluidly communicating with a fluid source, a peritoneal dialysis configured to be placed in fluid communication with the fluid line, the peritoneal dialysis including a first user interface and a first control unit, the first user interface configured to receive first user inputs related to a peritoneal dialysis treatment, the first control configured to operate the peritoneal dialysis in accordance with the first user inputs to perform the peritoneal dialysis treatment, and a blood treatment configured to be placed in fluid communication with the fluid line, the blood treatment including a second user interface and a second control unit, the second user interface configured to receive second user inputs related to a blood treatment, the second control configured to operate the blood treatment in accordance with the second user inputs to perform the blood treatment.

Abstract: A direct memory access controller intended to be placed in a computing node of a system on chip, comprising: an input buffer for receiving packets of data to be processed coming from an input/output interface of the computing node; a write control module for controlling the writing of the data extracted from each packet to a local address space of the computing node shared by at least one processor for processing said data other than the direct memory access controller; an arithmetic logic unit for executing microprograms. The write control module is designed to control the execution by the arithmetic logic unit of at least one microprogram consisting of instruction lines for arithmetic and/or logical calculation concerning only storage addresses for storing the data received by the input buffer for a reorganization of same in the shared local address space.

Abstract: The invention relates to FSH receptor antagonist according to general formula I or a pharmaceutically acceptable salt thereof and to a pharmaceutical composition containing the same. The compounds can be used for the treatment and prevention of endometriosis, for the treatment and prevention of pre-menopausal and peri-menopausal hormone-dependent breast cancer, for contraception, and for the treatment of uterine fibroids and other menstrual-related disorders.

Abstract: A method for dynamically controlling throughput set points from sources to targets in a network on a chip including a plurality of nodes and a plurality of links between these nodes for transmission of data packets, including for each link of the network solicited by the transmission of data packets, estimation of an available throughput margin that includes the estimation of a first margin calculated based on a maximum throughput capacity of the link; and for each emitting source of at least one data packet, the calculation and the application of an update of its throughput set point according to the estimated available throughput margins. Estimation of available throughput margin for each link includes estimation of a second margin calculated based on a maximum local absorption capacity of possible sporadic overflows of the throughput set points and its value is determined according to the first and second calculated margins.

Abstract: A dialysis system is configured to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments. The example dialysis system includes a base unit configurable to provide a first fluid for use in preforming at least one peritoneal dialysis treatment at a first time. The base unit is further configurable to provide a second, different fluid for use in at least one extracorporeal blood treatment at a second, different time. The example dialysis system also includes a blood treatment unit configured to be docked to the base unit. The blood treatment unit includes a blood pump configured to pump blood from the patient to a blood filter and from the blood filter back to the patient. The blood filter or a blood line in communication with the blood filter receives the second fluid from the base unit for use in the at least one extracorporeal blood treatment.

Abstract: A method for a hybrid blood and peritoneal dialysis (“PD”) machine comprising: (i) determining whether a previous treatment left a last fill of dialysate in a patient's peritoneum; (ii) if a next treatment is a PD treatment, and if the previous treatment did not leave the last fill of dialysate, causing a PD treatment in which a first cycle is a fill cycle to be initiated; (iii) if the next treatment is a PD treatment, and if the previous treatment did leave the last fill of dialysate, causing a PD treatment in which a first cycle is a last fill drain cycle to be initiated; and (iv) if the next treatment is a blood treatment and if the previous treatment did leave the last fill of dialysate, causing a blood treatment including a last fill drain cycle to be initiated.

Abstract: A hybrid hemodialysis (“HD”)/peritoneal dialysis (“PD”) system includes: a reservoir; a weigh scale operably coupled with the reservoir; and at least one controller programmed to run (i) an HD treatment in which blood is pumped to a blood compartment of a dialyzer, fresh HD dialysis fluid is pumped to a dialysis fluid compartment of the dialyzer, and used HD dialysis fluid is pumped from the dialysis fluid compartment of the dialyzer to the reservoir, and at a different time (ii) a PD treatment in which fresh PD dialysis fluid is pumped to a patient and used PD dialysis fluid is pumped from the patient to the reservoir.

Abstract: A dialysis system includes a fluid line fluidly communicating with a fluid source, a peritoneal dialysis unit configured to be placed in fluid communication with the fluid line, the peritoneal dialysis unit including a first user interface and a first control unit, the first user interface configured to receive first user inputs related to a peritoneal dialysis treatment, the first control unit configured to operate the peritoneal dialysis unit in accordance with the first user inputs to perform the peritoneal dialysis treatment, and a blood treatment unit configured to be placed in fluid communication with the fluid line, the blood treatment unit including a second user interface and a second control unit, the second user interface configured to receive second user inputs related to a blood treatment, the second control unit configured to operate the blood treatment unit in accordance with the second user inputs to perform the blood treatment.