Abstract: A method checks a plug connection, in which a first plug part is connected to a second plug part. The method determines a force-time curve of a force applied by an assembler during an assembly process of a plug connection. In addition, the method determines characteristic values of a plurality of characteristics of the force-time curve. The method also classifies the plug connection by use of a machine-learned classifier on the basis of the characteristic values of the plurality of characteristics.

Abstract: A method checks a plug connection, in which a first plug part is connected to a second plug part. The method determines a force-time curve of a force applied by an assembler during an assembly process of a plug connection. In addition, the method determines characteristic values of a plurality of characteristics of the force-time curve. The method also classifies the plug connection by use of a machine-learned classifier on the basis of the characteristic values of the plurality of characteristics.

Abstract: The present invention relates generally to methods and compositions for reducing Interleukin-4 or Interleukin-13 signaling, in particular to treat asthma and atopic dermatitis. The inventors have found that Rac/PAK mediated endocytosis of the ligand bound type I (IL-4R with the chains IL-4Ra and IL-2-Rg) and/or type II receptor (IL-13R with the chains IL-4Ra and IL-13Ra1) is needed for the IL-4 and/or IL-13 mediated activation of downstream signalling events including phosphorylation of Stat family transcrition factors. These discoveries enable new methods of screening compounds that modulate Interleukin-4 and Interleukin-13 signalling, as well as new methods for treating conditions characterized by increased Interleukin-4 and Interleukin-13 levels. These conditions include inflammatory conditions, asthma bronchiale, atopic dermatitis, allergies, atopic syndromes, allergic rhinitis, and th2-induced conditions.

Abstract: The invention comprises a fusion protein as sensor for TGF-beta receptor activity, a method for detecting receptor activity and to screening compounds for modulators of receptor activity. The fusion protein comprises a type I TGF-beta receptor, a circularly permutated fluorescent protein moiety (cpFP) and an activation state specific receptor binding domain, binding specifically to either the activated or inactive form of the TGF-beta receptor. An activation specific interaction between the receptor and the activation state specific receptor binding domain modulates the fluorescence of the cpFP inserted in between. Thus, activation of the receptor can be detected directly by a change in fluorescence of the cpFP.