Patents by Inventor Christian Bolle

Christian Bolle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10988758
    Abstract: The present invention relates to monodisperse silanized ferrimagnetic iron oxide particles, a method for producing the same and a method for independent generic binding of nucleic acid molecules to the particles.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: April 27, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Jens Christian Bolle, Thomas Walter, Peter Wenzig
  • Patent number: 10573443
    Abstract: Disclosed is a simplified process for producing magnetic polymer particles. The process comprises: (a) providing a composition having a liquid monomer which is radical polymerizable, a radical initiator soluble in the monomer, a steric stabilizer, and a ferrofluid comprising surfactant-coated colloidal magnetic particles in a carrier fluid which is miscible with the monomer; (b) preparing an emulsion from a polar solvent which is immiscible with the monomer, and the composition of step (a); (c) adding seed polymer particles to the emulsion, mixing to form a seeded emulsion, and incubating the seeded emulsion, thereby swelling the seed polymer particles; and (d) activating the radical initiator and polymerizing the monomer in the swollen seed polymer particles; thereby producing the magnetic polymer particles. The process forms monodisperse magnetic particles. The particles are characterized by a uniform distribution of magnetic material, and an absence of magnetite bleeding.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: February 25, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christoph Seidel, Jens Christian Bolle, Sandra Recklies
  • Publication number: 20200041502
    Abstract: The present disclosure relates to magnetic particles, wherein each particle has a polymer matrix and at least one magnetic core (M), wherein the polymer matrix has at least one crosslinked polymer and wherein the magnetic particle has a particle size in the range of from 1 to 60 micrometer. Further, the present disclosure relates to a method of preparing such particles, and to particles obtainable or obtained by said method. Moreover, the present disclosure uses these magnetic particles for qualitative and/or quantitative determination of at least one analyte in a fluid. Further, the present disclosure relates to a method for determining at least one analyte in a fluid sample using the contacting of a magnetic particle of the disclosure or a magnetic particle obtained by the method of the present disclosure with a fluid sample having or suspected to have the at least one analyte.
    Type: Application
    Filed: October 11, 2019
    Publication date: February 6, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Jens Christian Bolle, Martin Eduardo Silvestre, Stephan Hug, Carolyn Bylda
  • Publication number: 20190002871
    Abstract: The present invention relates to monodisperse silanized ferrimagnetic iron oxide particles, a method for producing the same and a method for independent generic binding of nucleic acid molecules to the particles.
    Type: Application
    Filed: August 21, 2018
    Publication date: January 3, 2019
    Inventors: Jens Christian Bolle, Thomas Walter, Peter Wenzig
  • Patent number: 10100301
    Abstract: The present invention relates to monodisperse silanized ferrimagnetic iron oxide particles, a method for producing the same and a method for independent generic binding of nucleic acid molecules to the particles.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: October 16, 2018
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Jens Christian Bolle, Thomas Walter, Peter Wenzig
  • Publication number: 20160276080
    Abstract: Disclosed is a simplified process for producing magnetic polymer particles. The process comprises: (a) providing a composition having a liquid monomer which is radical polymerizable, a radical initiator soluble in the monomer, a steric stabilizer, and a ferrofluid comprising surfactant-coated colloidal magnetic particles in a carrier fluid which is miscible with the monomer; (b) preparing an emulsion from a polar solvent which is immiscible with the monomer, and the composition of step (a); (c) adding seed polymer particles to the emulsion, mixing to form a seeded emulsion, and incubating the seeded emulsion, thereby swelling the seed polymer particles; and (d) activating the radical initiator and polymerizing the monomer in the swollen seed polymer particles; thereby producing the magnetic polymer particles. The process forms monodisperse magnetic particles. The particles are characterized by a uniform distribution of magnetic material, and an absence of magnetite bleeding.
    Type: Application
    Filed: June 1, 2016
    Publication date: September 22, 2016
    Inventors: Christoph Seidel, Jens Christian Bolle, Sandra Recklies
  • Publication number: 20150252357
    Abstract: The present invention relates to monodisperse silanized ferrimagnetic iron oxide particles, a method for producing the same and a method for independent generic binding of nucleic acid molecules to the particles.
    Type: Application
    Filed: March 3, 2015
    Publication date: September 10, 2015
    Inventors: Jens Christian Bolle, Thomas Walter, Peter Wenzig
  • Patent number: 8774580
    Abstract: An optical device comprising a substrate having a planar surface and an optical waveguide located on and parallel to the planar surface and having an end located and oriented to emit or receive light propagating substantially parallel to the planar surface. The device also comprises a crystalline turning mirror bound to the planar surface, the crystalline turning mirror having a bottom surface along the planar surface and having a reflecting surface that is slanted relative to said planar surface. The crystalline turning mirror and the substrate are formed of different materials.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: July 8, 2014
    Assignee: Alcatel Lucent
    Inventor: Christian Bolle
  • Patent number: 8159218
    Abstract: A method of manufacturing an apparatus 200 comprising forming an integrated magnetometer package 202. Forming an integrated magnetometer package 202 includes forming a movable part 215 from a MEM magnetometer substrate 210, and attaching an integrated circuit 910 to one side 212 of the MEM magnetometer substrate. A spacer structure 410 is formed on an opposite side of the MEM magnetometer substrate such that the moveable part is exposed through an opening 420 in the spacer structure. But the moveable part cannot escape through said opening. A permanent magnet 1010 is mounted through the opening to the movable part.
    Type: Grant
    Filed: August 4, 2008
    Date of Patent: April 17, 2012
    Assignee: Alcatel Lucent
    Inventor: Christian Bolle
  • Publication number: 20110129181
    Abstract: An optical device comprising a substrate having a planar surface and an optical waveguide located on and parallel to the planar surface and having an end located and oriented to emit or receive light propagating substantially parallel to the planar surface. The device also comprises a crystalline turning mirror bound to the planar surface, the crystalline turning mirror having a bottom surface along the planar surface and having a reflecting surface that is slanted relative to said planar surface. The crystalline turning mirror and the substrate are formed of different materials.
    Type: Application
    Filed: December 2, 2009
    Publication date: June 2, 2011
    Applicant: Alcatel - Lucent USA Inc.
    Inventor: Christian Bolle
  • Patent number: 7932727
    Abstract: Electrical and visual test structures monitor the degree of removal of conductive sacrificial layers used in micromachining processes that fabricate micro-electromechanical systems (MEMS).
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: April 26, 2011
    Inventors: Christian Bolle, Flavio Pardo
  • Publication number: 20100026290
    Abstract: A method of manufacturing an apparatus 200 comprising forming an integrated magnetometer package 202. Forming an integrated magnetometer package 202 includes forming a movable part 215 from a MEM magnetometer substrate 210, and attaching an integrated circuit 910 to one side 212 of the MEM magnetometer substrate. A spacer structure 410 is formed on an opposite side of the MEM magnetometer substrate such that the moveable part is exposed through an opening 420 in the spacer structure. But the moveable part cannot escape through said opening. A permanent magnet 1010 is mounted through the opening to the movable part.
    Type: Application
    Filed: August 4, 2008
    Publication date: February 4, 2010
    Applicant: Lucent Technologies Inc.
    Inventor: Christian Bolle
  • Patent number: 7253616
    Abstract: An apparatus comprising a substrate and a MEM device. The MEM includes a comb capacitor and a magnetic element physically connected to one electrode of the comb capacitor. The magnetic element is capable of moving the one electrode in a manner that alters a capacitance of the comb capacitor. The apparatus also includes at least one spring physically connecting the magnetic element to the substrate.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: August 7, 2007
    Assignee: Lucent Technologies Inc.
    Inventors: Christian A. Bolle, Maria E. Simon