Abstract: A method and device for detecting a worsening of the cardiopulmonary state of a patient treated by a respiratory assistance device comprising means for gathering and processing parameters which are representative of a first parameter that is representative of the patient's respiratory frequency over a first observation window, e.g. daily; a second parameter that is representative of the percentage of cycles that were initiated by the patient during a second observation window, e.g. daily; and a third parameter that is representative of the usage time of the device during a third observation window, e.g. daily.

Abstract: A breathable gas supply regulation device of gas supplied by a respiratory assistance apparatus in breath assistance comprising a first input receiving a leakage signal produced by a detection member. The device regulates the supply of breathable gas to the patient in response to a received leakage signal, comprises a second input receiving a patient mouth movement measurement signal. The device comprises a processing unit provided for generating a synchronisation signal between the movement signal and the leakage signal. The processing unit generates a modification amount indicating the modification to be applied to the supply of breathable gas.

Abstract: The invention relates to novel acyl derivatives of rifamycins of the formula ##STR1## and the salts thereof, in which the structural elements --A.sub.1 --A.sub.2 --, --A.sub.3 --A.sub.4 -- and --A.sub.5 --A.sub.6 -- each denote ethylene or vinylene or the elements --A.sub.1 --A.sub.2 -- and --A.sub.3 --A.sub.4 -- each denote ethylene and --A.sub.5 --A.sub.6 -- denotes vinylene; X represents >C(R.sub.6)-- or >N-- and R.sub.6 denotes hydrogen or alkyl; alk denotes an aliphatic hydrocarbon radical; R.sub.1 denotes hydrogen or acyl; R.sub.2 denotes acyl, or alkyl which is optionally substituted by an aromatic radical, and R.sub.3 and R.sub.3 ' represent a common bond, or R.sub.3 denotes hydrogen or acyl, and R.sub.3 ' is hydrogen; R.sub.4 denotes hydrogen, cycloalkyl or aryl; R.sub.5 denotes hydrogen or acetyl; R.sub.7 denotes hydrogen or alkyl, which can be used as active compounds in medicaments, the preparation and use thereof, and pharmaceutical products and the preparation thereof.

Abstract: Compounds of the formula I ##STR1## wherein the groups A, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification, exhibit valuable pharmacological properties, especially as antifibrotic agents. They are prepared by methods known per se.