Patents by Inventor Christian C. Simonsen

Christian C. Simonsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human tPA production using vectors coding for DHFR protein
    Patent number: 6261837
    Abstract: A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild type DHFR with methotrexate.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: July 17, 2001
    Assignee: Genentech, Inc.
    Inventors: Arthur D. Levinson, Diane Pennica, William J. Kohr, Gordon A. Vehar, David V. Goeddel, Elizabeth M. Yelverton, Christian C. Simonsen
  • Human tPA production using vectors coding for DHFR protein
    Patent number: 5849574
    Abstract: A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild type DHFR with methotrexate.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: December 15, 1998
    Assignee: Genentech, Inc.
    Inventors: Arthur D. Levinson, Diane Pennica, William J. Kohr, Gordon A. Vehar, David V. Goeddel, Elizabeth M. Yelverton, Christian C. Simonsen
  • Hepatitis C virus epitopes
    Patent number: 5843639
    Abstract: Peptide antigens which are immunoreactive with sera from individuals infected with hepatitis C virus (HCV) are disclosed. Several of the antigens are immunologically reactive with antibodies present in individuals identified as having chronic and acute HCV infection. The antigens are useful in diagnostic methods for detecting HCV infection in humans. Also disclosed are corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic peptides.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 1, 1998
    Assignee: Genelabs Technologies, Inc.
    Inventors: Gregory R. Reyes, Jungsuh P. Kim, Randolph Moeckli, Christian C. Simonsen
  • Hepatitis C virus epitopes
    Patent number: 5843636
    Abstract: Peptide antigens which are immunoreactive with sera from individuals infected with hepatitis C virus (HCV) are disclosed. Several of the antigens are immunologically reactive with antibodies present in individuals identified as having chronic and acute HCV infection. The antigens are useful in diagnostic methods for detecting HCV infection in humans. Also disclosed are corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic peptides.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: December 1, 1998
    Assignee: Genelabs Technologies, Inc.
    Inventors: Gregory R. Reyes, Jungsuh P. Kim, Randolph Moeckli, Christian C. Simonsen
  • Recombinant purified protease nexin
    Patent number: 5495001
    Abstract: DNA segments encoding two slightly different protease nexin I forms (PN-I.alpha. and PN-I.beta.) are cloned and expressed to provide practical quantities of PN-I for diagnostic and therapeutic use. PN-I is a serine protease inhibitor useful in controlling conditions mediated by proteolytic activity.
    Type: Grant
    Filed: August 10, 1994
    Date of Patent: February 27, 1996
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Michael P. McGrogan, Randy W. Scott, Joffre B. Baker, Christian C. Simonsen, Sr.
  • Human tPA production using vectors coding for DHFR protein
    Patent number: 5424198
    Abstract: A method for producing tissue plasminogen activator (t-PA)in eukaroytic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild-type DHFR with methotrexate.
    Type: Grant
    Filed: December 3, 1993
    Date of Patent: June 13, 1995
    Assignee: Genentech, Inc.
    Inventors: Arthur D. Levinson, Diane Pennica, William J. Kohr, Gordon A. Vehar, David V. Goeddel, Elizabeth M. Yelverton, Christian C. Simonsen
  • Human t-PA production using vectors coding for DHFR protein
    Patent number: 5268291
    Abstract: A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild-type DHFR with methotrexate.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: December 7, 1993
    Assignee: Genentech, Inc.
    Inventors: Arthur D. Levinson, Diane Pennica, William J. Kohr, Gordon A. Vehar, David V. Goeddel, Christian C. Simonsen
  • Human tPA production using vectors coding for DHFR protein
    Patent number: 5011795
    Abstract: A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild type DHFR with methotrexate.
    Type: Grant
    Filed: March 22, 1990
    Date of Patent: April 30, 1991
    Assignee: Genentech, Inc.
    Inventors: Arthur D. Levinson, Diane Pennica, William J. Kohr, Gordon A. Vehar, David V. Goeddel, Elizabeth M. Yelverton, Christian C. Simonsen
  • Polycistronic expression vector construction
    Patent number: 4713339
    Abstract: A polycistronic construction of xenogeneic sequences expressible in eukaryotic cells is described. DHFR encoding sequences under control of the same promoter with another foreign gene can be amplified with methotrexate, and thus cause coamplification of the foreign gene.
    Type: Grant
    Filed: January 19, 1983
    Date of Patent: December 15, 1987
    Assignee: Genentech, Inc.
    Inventors: Arthur D. Levinson, Christian C. Simonsen
  • Human tPA production using vectors coding for DHFR protein
    Patent number: H2181
    Abstract: A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild-type DHFR with methotrexate.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: February 6, 2007
    Assignee: Genentech, Inc.
    Inventors: Arthur D. Levinson, Diane Pennica, William J. Kohr, Gordon A. Vehar, David V. Goeddel, Elizabeth M. Yelverton, Christian C. Simonsen