Abstract: The disclosure relates to medical devices and methods of manufacturing medical devices. An orthopedic screw includes an inner core member having a head having a first outer diameter, a tip having a second outer diameter, and a body extending between the head and the tip and having a third outer diameter that is less than the first outer diameter and the second outer diameter. An outer body member is disposed circumferentially around the body of the inner core member and defines an outer body member external thread. The tip of the inner core member can define an inner core member external thread that forms an interrupted thread with the outer body member external thread.

Abstract: A composition for dyeing keratin fibres comprising a. at least one azomethine compound selected from compounds (3) and (4) and b. water. The composition may be used in a process for dyeing keratin fibres or, with simultaneous or sequential application of a composition comprising one or more oxidising agents, in a process for lightening keratin fibres.

Abstract: A composition for dyeing keratin fibres comprising a. at least one azomethine compound selected from compounds (3) and (4) and b. water. The composition may be used in a process for dyeing keratin fibres or, with simultaneous or sequential application of a composition comprising one or more oxidising agents, in a process for lightening keratin fibres.

Abstract: The invention relates to cationic direct dyes of the formula I (1), wherein m and n are independently from each other 0 or 1, D is an aromatic or a cationic heteroaromatic group, which are further specified, K is an aromatic or heteroaromatic group, E1 and E2 are independently from each other ?CH— or ?N—, An is an anion and a is a number from 1 to 6 and R1 and R2 are independently from each other and further specified. The compounds show washfastness at hair-dying.

Abstract: The technology provided herein relates to novel human cytolytic fusion proteins (hCFPs) suitable to induce apoptosis in human cells comprising a target cell-specific binding component and a human effector domain, wherein the binding component comprises an antibody or an antibody fragment with an antigen-binding site for binding to the cellular surface receptor CD64 and the effector domain comprises a variant of wild type human angiogenin (Ang) or a functional fragment thereof; to nucleic acid molecules encoding said recombinant hCFPs, vectors and host cells containing said nucleic acids and methods for preparation and producing these hCFPs.

Abstract: The invention relates to cationic direct dyes of the formula I (1), wherein m and n are independently from each other 0 or 1, D is an aromatic or a cationic heteroaromatic group, which are further specified, K is an aromatic or heteroaromatic group, E1 and E2 are independently from each other ?CH— or ?N—, An is an anion and a is a number from 1 to 6 and R1 and R2 are independently from each other and further specified. The compounds show washfastness at hair-dying.

Abstract: Disclosed are styryl dyes of formula wherein R1, R2, R3, R?1, R?2 and R?3 independently of each other are hydrogen; —NH(CO)—C1-C5alkyl; —N(C1-C5alkyl)(C1-C5alkyl-CN); C1-C6alkoxy; a heterocyclic radical; or R1 and R2 or R?1 and R?2 together form a 5- to 10-membered, monocyclic, carbocyclic or heterocyclic ring; wherein at least one of R1, R2, R3, R?1, R?2 and R?3 is different from hydrogen; Q and Q? independently from each other are the direct bond; *—C(O)—*; *—C(O)O—*; *—OCO—*; *—N(R4)—*; ?*—C(O)N(R6)—*; or *—(R6)NC(O)—*; and R4, R5 and R6 independently from each other are hydrogen; C1-C14alkyl; C2-C14alkenyl; C6-C12aryl; C6-C12aryl-C1-C10alkyl; or C1-C10alkyl(C5-C12aryl); X and X? are *—(CH2)m—*; Y1 and Y2 independently from each other are C1-C10alkylene; C5-C10cycloalkylene; C5-C12arylene; or C5-C12arylene-(C1-C10alkylene); An? is an anion; m is a number from 1 to 8; n is 0, or 1; and p is 0, or 1.

Abstract: The technology provided herein relates to novel human cytolytic fusion proteins (hCFPs) suitable to induce apoptosis in human cells comprising a target cell-specific binding component and a human effector domain, wherein the binding component comprises an antibody or an antibody fragment with an antigen-binding site for binding to the cellular surface receptor CD64 and the effector domain comprises a variant of wild type human angiogenin (Ang) or a functional fragment thereof; to nucleic acid molecules encoding said recombinant hCFPs, vectors and host cells containing said nucleic acids and methods for preparation and producing these hCFPs.

Abstract: Disclosed are styryl dyes of formula wherein R1, R2, R3, R?1, R?2 and R?3 independently of each other are hydrogen; —NH(CO)—C1-C5alkyl; —N(C1-C5alkyl)(C1-C5alkyl-CN); C1-C6alkoxy; a heterocyclic radical; or R1 and R2 or R?1 and R?2 together form a 5- to 10-membered, monocyclic, carbocyclic or heterocyclic ring; wherein at least one of R1, R2, R3, R?1, R?2 and R?3 is different from hydrogen; Q and Q? independently from each other are the direct bond; *—C(O)—*; *—C(O)O—*; *—OCO—*; *—N(R4)—*; *—C(O)N(R6)—*; or *—(R6)NC(O)—*; and R4, R5 and R6 independently from each other are hydrogen; C1-C14alkyl; C2-C14alkenyl; C6-C12aryl; C6-C12aryl-C1-C10alkyl; or C1-C10alkyl(C5-C12aryl); X and X? are *—(CH2)m—*; Y1 and Y2 independently from each other are C1-C10alkylene; C6-C10cycloalkylene; C5-C12arylene; or C6-C12arylene-(C1-C10alkylene); An? is an anion; m is a number from 1 to 8; n is 0, or 1; and p is 0, or 1.

Abstract: Disclosed are compounds of formula (1) or formula (2). The compounds are useful for the dyeing of organic materials, such as keratin fibers, wool, leather, silk, cellulose or polyamides, especially keratin-containing fibers, cotton or nylon, and preferably hair, more preferably human hair. (1) (2).

Abstract: Functionalized nanoparticles, which are obtainable by combining in a first step a functionalized dyestuff, a silicon-based spacer and a catalyst, and in a second step reacting the product obtained in the first step with a co-reactive organic silicon, aluminum, zirconium or titanium compound. Optionally, the thus obtained functionalized nanoparticles can be combined or encapsulated with a polymer. The functionalized nanoparticles are useful as colorants and fluorescents in plastics, paints, inks, electronic materials, cosmetic articles, and the like.

Abstract: Disclosed are compounds of formula (1) or formula (2). The compounds are useful for the dyeing of organic materials, such as keratin fibers, wool, leather, silk, cellulose or polyamides, especially keratin-containing fibers, cotton or nylon, and preferably hair, more preferably human hair. (1) (2).

Abstract: The present invention relates to the reaction product of (A) a polymeric backbone with (B) A chromophore; and with (C) at least one sulfide containing compound. Very good dyeing results are obtained with this new technology.

Abstract: The present invention relates to the reaction product of (A) a polymeric backbone with (B) A chromophore; and with (C) at least one sulfide containing compound. Very good dyeing results are obtained with this new technology.

Abstract: Disclosed are polymeric dyes of formula (1a), (1b), or (1c); wherein the substituents and variables are defined in the claims and specification. The dyes are distinguished by their depth of shade and their good fastness properties to washing, such as, for example, fastness to light, shampooing and rubbing.

Abstract: Polymeric dye comprising oligo and polypeptides selected from natural or synthetic aminoacids bearing at least one covalently bounded cationic dye. Very good dyeing results on human hair are obtained with these dyes.

Abstract: Disclosed are cationic polymeric dye with a hue value of h=210° to 330° comprising: a) a polymer backbone, b) a residue of an organic dye, and c) optionally colorless organic groups, wherein (b) and (c) are covalently bound to the polymer backbone (a), and wherein the cationic charges can independently be part of the dye or the colorless organic groups. The dyes are distinguished by their depth of shade and their good fastness properties to washing, such as, for example, fastness to light, shampooing and rubbing.

Abstract: Disclosed are polymeric dyes of formula (1a), (1b), or (1c); wherein A and B, independently from each other represent a polymer backbone; X1 and X2 independently from each other are a linkage group selected from —S—, —S—S—, —N—, —N?—, —N(R5)—, —S(O)—, —SO2—, —(CH2CH2—O)1-5—, —(CH2CH2CH2—O)1-5—, —C(O)—, —C(O)O—, —OCO—, (formula II) —CON(R1)—, —C(NR1R2)2—, —(R1)NC(O)—, —C(S)R1—; which may be interrupted and/or terminated at one or both ends by one or more than one —C1C30alkylene- or —C2-C12alkenylene-; or an optionally substituted, saturated or unsaturated, fused or non-fused aromatic or nonaromatic (heterocyclic) bivalent radical optionally comprising at least one heteroatom; a saturated or unsaturated, fused or non-fused aromatic or nonaromatic bivalent radical comprising at least one heteroatom, which is optionally substituted by C1-C30alkyl, C1-C30alkoxy, C2-C12alkenyl, C5-C10aryl, C5-C10cycloalkyl, C1-C10alkyl(C5-C10arylene), hydroxy or halogen; R1 and R2 independently from each other are hydrogen; unsubst

Abstract: Disclosed are polymeric dyes obtained by the reaction of (a) a basic polycondensate with (b) an electrophilic dye of formula (2) P—X—Ya+ Ana+; wherein the basic polycondensate (a) is obtained by the reaction of (a1) an amine of formula (I) in the presence of an anhydrous solvent with an ammonium salt (a2) with a cyanamide: Wherein P, X, Y, a+, a, a1, a2, An, R1, R2, R3, R4, R5, R6 and A are defined in the claims and in the disclosure. The present invention also relates to compositions comprising these polymeric dyes, to a process for their use for dyeing of organic materials, such as keratin fibers, wool, leather, silk, cellulose or polyamides.

Abstract: Disclosed are cationic oligomeric dye, comprising a low molecular weight polyamine comprising the repeating units (1a) or (1b), wherein at least 90% of the polyamine molecules are selected from tetramines, pentamines and hexamines; and R is the residue of a cationic dye, which is covalently bonded, optionally via a linker, to the nitrogen atoms of the polyamine; or hydrogen; wherein the polyamine repeating units (1a) and (1b) comprise at least one carionic dye residue; and n is a number from 3-12. The dyes are distinguished by their depth of shade and their good fastness properties to washing, such as, for example, fastness to light, shampooing and rubbing.