Patents by Inventor Christian Demitri

Christian Demitri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for Weight Management and for Improving Glycemic Control
    Publication number: 20230320384
    Abstract: The present invention provides methods, compositions and modified foods and foodstuffs useful for weight management and glycemic control.
    Type: Application
    Filed: November 7, 2022
    Publication date: October 12, 2023
    Inventors: Alessandro Sannino, Luigi Ambrosio, Eyal S. Ron, Yishai Zohar, Christian Demitri
  • Compositions and Methods for Treating or Preventing Gut Permeability-Related Disorders
    Publication number: 20220133771
    Abstract: Compositions and methods are provided for treating a gut permeability-related disease or disorder comprising administering to the gastrointestinal tract of a subject in need thereof, a therapeutically effective amount of a hydrogel having an elastic modulus (G?) of at least about 500 Pa.
    Type: Application
    Filed: October 14, 2021
    Publication date: May 5, 2022
    Inventors: Maria Rescigno, Alessandro Sannino, Yishai Zohar, Elaine Chiquette, Alessandra Silvestri, Christian Demitri
  • Method for Producing Hydrogels Coupling High Elastic Modulus and Absorbance
    Publication number: 20220073652
    Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.
    Type: Application
    Filed: September 21, 2021
    Publication date: March 10, 2022
    Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
  • METHOD FOR PRODUCING HYDROGELS
    Publication number: 20220073651
    Abstract: The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.
    Type: Application
    Filed: September 21, 2021
    Publication date: March 10, 2022
    Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Barry J. Hand, Eyal S. Ron
  • Polymer Hydrogels and Methods of Preparation Thereof
    Publication number: 20210353665
    Abstract: The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.
    Type: Application
    Filed: May 28, 2021
    Publication date: November 18, 2021
    Inventors: Alessandro Sannino, Luigi Ambrosio, Luigi Nicolais, Christian Demitri
  • Method for producing hydrogels coupling high elastic modulus and absorbance
    Patent number: 11130824
    Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: September 28, 2021
    Assignee: Gelesis LLC
    Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
  • Method for producing hydrogels
    Patent number: 11130823
    Abstract: The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: September 28, 2021
    Assignee: Gelesis LLC
    Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Barry Joseph Hand, Eyal S. Ron
  • Superabsorbent materials and methods of production thereof
    Patent number: 11020421
    Abstract: The present invention relates to new methods for crosslinking a polysaccharide with a bifunctional poly(ethylene glycol). The invention further includes the polymer hydrogels which can be produced using these methods, compositions comprising the polymer hydrogels and methods of use thereof.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: June 1, 2021
    Assignee: Gelesis LLC
    Inventors: Vincenzo Maria De Benedictis, Christian Demitri, Alessandro Sannino
  • COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING GUT PERMEABILITY-RELATED DISORDERS
    Publication number: 20200330502
    Abstract: Compositions and methods are provided for treating a gut permeability-related disease or disorder comprising administering to the gastrointestinal tract of a subject in need thereof, a therapeutically effective amount of a hydrogel having an elastic modulus (G?) of at least about 500 Pa.
    Type: Application
    Filed: January 27, 2020
    Publication date: October 22, 2020
    Inventors: Maria Rescigno, Alessandro Sannino, Yishai Zohar, Elaine Chiquette, Alessandra Silvestri, Christian Demitri
  • METHOD FOR PRODUCING HYDROGELS
    Publication number: 20200332025
    Abstract: The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.
    Type: Application
    Filed: January 27, 2020
    Publication date: October 22, 2020
    Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Barry Joseph Hand, Eyal S. Ron
  • METHOD FOR PRODUCING HYDROGELS COUPLING HIGH ELASTIC MODULUS AND ABSORBANCE
    Publication number: 20200277407
    Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.
    Type: Application
    Filed: March 9, 2020
    Publication date: September 3, 2020
    Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
  • Compositions and methods for treating or preventing gut permeability-related disorders
    Patent number: 10695363
    Abstract: Compositions and methods are provided for treating a gut permeability-related disease or disorder comprising administering to the gastrointestinal tract of a subject in need thereof, a therapeutically effective amount of a hydrogel having an elastic modulus (G?) of at least about 500 Pa.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: June 30, 2020
    Assignee: Gelesis LLC
    Inventors: Maria Rescigno, Alessandro Sannino, Yishai Zohar, Elaine Chiquette, Alessandra Silvestri, Christian Demitri
  • Method for producing hydrogels coupling high elastic modulus and absorbance
    Patent number: 10584183
    Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: March 10, 2020
    Assignee: Gelesis, LLC
    Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
  • POLYMER HYDROGELS AND METHODS OF PREPARATION THEREOF
    Publication number: 20200046755
    Abstract: The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.
    Type: Application
    Filed: August 21, 2019
    Publication date: February 13, 2020
    Inventors: Alessandro Sannino, Luigi Ambrosio, Luigi Nicolais, Christian Demitri
  • Method for producing hydrogels
    Patent number: 10544233
    Abstract: The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: January 28, 2020
    Assignee: Gelesis LLC
    Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Barry Joseph Hand, Eyal S. Ron
  • METHOD FOR PRODUCING HYDROGELS COUPLING HIGH ELASTIC MODULUS AND ABSORBANCE
    Publication number: 20190233545
    Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.
    Type: Application
    Filed: December 14, 2018
    Publication date: August 1, 2019
    Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
  • Method for producing hydrogels coupling high elastic modulus and absorbance
    Patent number: 10179824
    Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: January 15, 2019
    Assignee: GELESIS LLC
    Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
  • COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING GUT PERMEABILITY-RELATED DISORDERS
    Publication number: 20180333428
    Abstract: Compositions and methods are provided for treating a gut permeability-related disease or disorder comprising administering to the gastrointestinal tract of a subject in need thereof, a therapeutically effective amount of a hydrogel having an elastic modulus (G?) of at least about 500 Pa.
    Type: Application
    Filed: April 16, 2018
    Publication date: November 22, 2018
    Inventors: Maria Rescigno, Alessandro Sannino, Yishai Zohar, Elaine Chiquette, Alessandra Silvestri, Christian Demitri
  • Method for treating constipation
    Patent number: 10098907
    Abstract: The present invention provides a method of treating constipation and compositions useful in said method. The method comprises administering to a subject in need thereof an effective amount of a crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: October 16, 2018
    Assignee: GELESIS LLC
    Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
  • METHODS AND COMPOSITIONS FOR WEIGHT MANAGEMENT AND FOR IMPROVING GLYCEMIC CONTROL
    Publication number: 20180289043
    Abstract: The present invention provides methods, compositions and modified foods and foodstuffs useful for weight management and glycemic control.
    Type: Application
    Filed: April 2, 2018
    Publication date: October 11, 2018
    Inventors: Alessandro Sannino, Luigi Ambrosio, Eyal S. Ron, Yishai Zohar, Christian Demitri