Patents by Inventor Christian Dorrer

Christian Dorrer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170044483
    Abstract: An apparatus for purifying biological molecules, especially nucleic acids or proteins, includes at least one filter and a circuit. A method of purifying biological molecules using the apparatus includes pumping at least some fluids into the circuit via the filter. Fluid with biological cells is pumped into the circuit via the filter, and cells retained on the filter are digested. Binding buffer is pumped into the circuit via the filter in order to bind the biological molecules to the filter. A washing buffer is pumped into the circuit via the filter in order to clean the biological molecules bound to the filter so that the biological molecules bound to the filter are enabled for further use.
    Type: Application
    Filed: April 17, 2015
    Publication date: February 16, 2017
    Applicant: Robert Bosch GmbH
    Inventors: Bernd Faltin, Christian Dorrer
  • Patent number: 9515159
    Abstract: An electronic sensor apparatus for detecting chemical or biological species includes a semiconductor chip, a sensor device, and a substrate. The chip is produced from a semiconductor substrate and is configured for one or more functions such as: amplifying and/or evaluating an electrical voltage, amplifying and/or evaluating an electric current, amplifying and/or evaluating an electrical charge, and amplifying and/or reading out capacitance changes. The sensor device has an active surface configured to detect chemical or biological species and generate an electrical signal based on a species-characteristic interaction with the active surface. The electrical signal can be an electrical voltage, an electric current, an electrical charge and/or a capacitance change. The substrate is produced from a melt-moldable material and has a surface including first and second regions. The chip is at least partly embedded in the first region, and the sensor device is at least partly embedded in the second region.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: December 6, 2016
    Assignee: Robert Bosch GmbH
    Inventors: Georg Bischopink, Franz Laermer, Christian Dorrer, Thomas Brettschneider
  • Publication number: 20160263573
    Abstract: A device, especially a microfluidic device for performance of an immunoassay, has a first, a second and a third fluidically connected chamber and a membrane. In the event of a given deflection of the membrane into the first chamber, a first fluid is passed at least partly out of the first chamber into the second chamber in such a way that a second fluid is at least partly displaced from the second chamber into the third chamber in such a way that the third chamber is entirely filled with the second fluid.
    Type: Application
    Filed: October 16, 2014
    Publication date: September 15, 2016
    Inventors: Thomas Brettschneider, Christian Dorrer
  • Publication number: 20160186167
    Abstract: A method for processing a sample of biological material containing target cells and companion cells in order to extract nucleic acids of the target cells includes accumulating the target cells of the sample by separating the target cells or the companion cells from the sample. The method additionally includes decomposing the target cells by chemical or physical lysis in order to produce a target cell lysate containing the nucleic acids of the target cells. The method further includes purifying the nucleic acids from the target cell lysate in order to extract the nucleic acid of the target cells.
    Type: Application
    Filed: July 24, 2014
    Publication date: June 30, 2016
    Inventors: Bernd Faltin, Franz Laermer, Sebastian Berning, Christian Dorrer
  • Publication number: 20160177291
    Abstract: A method for preparing a sample of biological materials containing target cells and accompanying cells for extracting nucleic acids of the target cells includes accumulating the target cells of the sample by separating the target cells or the accompanying cells from the sample. The method also includes digesting the target cells via chemical and/or physical lysis in order to produce a target cell lysate containing the nucleic acids of the target cells. The method furthermore includes purifying the nucleic acids from the target cell lysate in order to extract the nucleic acids of the target cells.
    Type: Application
    Filed: July 30, 2014
    Publication date: June 23, 2016
    Inventors: Bernd Faltin, Franz Laermer, Jochen Rupp, Peter Rothacher, Christian Dorrer, Sebastian Berning
  • Patent number: 9188244
    Abstract: A microfluidic device includes a first supply channel and a first discharge channel fluidically connected to one another by a first valve. The device also includes a second supply channel and a second discharge channel fluidically connected to one another by a second valve. At least one of the first channels can be fluidically connected to at least one of the second channels by a T-valve. The device also includes a control unit for controlling the valves, the control unit being configured in such a way that a first fluid from one of the first channels and a second fluid in one of the second channels can be laminated in parallel by actuating the valves in one of the first or second channels. A microfluidic system and a method for transporting fluids, and a use thereof are also disclosed.
    Type: Grant
    Filed: July 4, 2012
    Date of Patent: November 17, 2015
    Assignee: Robert Bosch GmbH
    Inventors: Christian Dorrer, Jochen Rupp
  • Publication number: 20150307826
    Abstract: A method for processing organic cells includes providing a microfluidic system having a chamber comprising a stationary phase in the form of a plurality of microparticles. The method further includes letting a plurality of organic cells in a mobile phase into the chamber across a first opening of the microfluidic system. The method further includes accumulating the organic cells in a tapered section of the chamber that is upstream of a filter of the microfluidic system that is impermeable to the microparticles. The method further includes flushing a lysis agent into the chamber to resuspend the microparticles and the organic cells in the chamber for a disruption of the organic cells.
    Type: Application
    Filed: April 21, 2015
    Publication date: October 29, 2015
    Inventors: Christian Dorrer, Bernd Faltin
  • Patent number: 9149804
    Abstract: A microfluidic device includes at least two layers arranged one above the other, a membrane which is arranged between the at least two layers, a cavity in one of the at least two layers, and a channel in the other of the at least two layers. The membrane is arranged so as to be expandable between the cavity and the channel. The membrane is expandable into at least one specified displacement volume.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: October 6, 2015
    Assignee: Robert Bosch GmbH
    Inventors: Thomas Brettschneider, Christian Dorrer
  • Patent number: 9034162
    Abstract: A microfluidic cell for the dielectrophoretic separation, accumulation, and/or lysis of polarizable bioparticles, including an interdigital electrode system composed of two electrode groups having interdigitated electrodes, and a micromixer having microchannels and microelevations. The interdigital electrode system and the micromixer are situated on the same side of the cell to improve the separation, accumulation, and/or lysis characteristics. Moreover, also described is a microfluidic system which includes such a microfluidic cell, and use thereof, and a method for separating, accumulating, and/or lysing polarizable bioparticles.
    Type: Grant
    Filed: August 10, 2010
    Date of Patent: May 19, 2015
    Assignee: ROBERT BOSCH GMBH
    Inventors: Michael Stumber, Martina Daub, Jochen Rupp, Massimo Kubon, Peter Rothacher, Meike Moschallski, Martin Stelzle, Christian Dorrer
  • Patent number: 9034173
    Abstract: A microfluidic dielectrophoresis system includes: one supply device for a liquid medium having particles contained therein, N?2 microfluidic, dielectrophoretically active channels, which are equipped with electrodes, lines for the fluidic connection of the supply device to the channels, for the connection of the channels to one another, and for the drainage of the medium and/or the particles from the channels, and valves for setting the flow direction of the medium in the lines, the dielectrophoretically active channels being situated and being connected by lines in such a way that they may be operated connected in parallel and in series by switching the valves in relation to the flow direction of the medium and the electrodes of the various channels are activatable independently of one another.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: May 19, 2015
    Assignee: ROBERT BOSCH GMBH
    Inventor: Christian Dorrer
  • Patent number: 8956530
    Abstract: A system for separating bodily fluid constituents is disclosed. The system includes a first substrate which, in a first main surface, has a first cavity for holding a bodily fluid sample, a second substrate, which, in a first main surface facing the first substrate, has a second cavity) for holding constituents separated from the bodily fluid sample, which second cavity lies opposite to the first cavity, a filter layer, which is arranged between the first substrate and the second substrate and which is designed to separate constituents of the bodily fluid sample in the first cavity and to pass the separated constituents to the second cavity, and a first thermoplastic connection layer, which is arranged between the first substrate and the filter layer, interconnects the first main surface of the first substrate and the filter layer in a fluid-tight manner and has a cutout lying opposite to the first cavity.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: February 17, 2015
    Assignee: Robert Bosch GmbH
    Inventors: Christian Dorrer, Thomas Brettschneider
  • Publication number: 20140290373
    Abstract: A polymer layer system pressure sensor device includes a first polymer substrate having a first cavity and a first polymer membrane stretched over the first cavity. The first polymer membrane is configured to be deflected dependent on a pressure in the first cavity. The device further includes a first membrane metallization layer applied to the first polymer membrane above the first cavity. The first membrane metallization layer is configured to be deflected together with the first polymer membrane dependent on the pressure in the first cavity. The device further includes a second polymer substrate, arranged over the first polymer membrane, a second cavity, arranged over the first cavity, and a second polymer membrane, stretched over the second cavity. The device further includes a second membrane metallization layer applied to the second polymer membrane within the second cavity and includes a third polymer substrate arranged over the second polymer membrane.
    Type: Application
    Filed: July 3, 2012
    Publication date: October 2, 2014
    Applicant: Robert Bosch GmbH
    Inventors: Thomas Brettschneider, Christian Dorrer
  • Publication number: 20140227150
    Abstract: A microfluidic device includes at least two layers arranged one above the other, a membrane which is arranged between the at least two layers, a cavity in one of the at least two layers, and a channel in the other of the at least two layers. The membrane is arranged so as to be expandable between the cavity and the channel. The membrane is expandable into at least one specified displacement volume.
    Type: Application
    Filed: May 22, 2012
    Publication date: August 14, 2014
    Applicant: Robert Bosch GmbH
    Inventors: Thomas Brettschneider, Christian Dorrer
  • Publication number: 20140134002
    Abstract: A microfluidic peristaltic pump has an inflow channel, a first pumping chamber, which is operatively connected to the inflow channel by a first channel, and a first membrane. The pump also has a second pumping chamber, which is operatively connected to the inflow channel by a second channel, and a second membrane. A fluidic resistance of the first channel is different from a fluidic resistance of the second channel, and each channel is configured to realize a throttling function, such that the first and second membranes are deflected in a time sequence when a pressure is applied in the inflow channel, to realize a pumping function.
    Type: Application
    Filed: November 8, 2013
    Publication date: May 15, 2014
    Applicant: Robert Bosch GmbH
    Inventors: Thomas Brettschneider, Christian Dorrer
  • Publication number: 20140116882
    Abstract: A microfluidic dielectrophoresis system includes: one supply device for a liquid medium having particles contained therein, N?2 microfluidic, dielectrophoretically active channels, which are equipped with electrodes, lines for the fluidic connection of the supply device to the channels, for the connection of the channels to one another, and for the drainage of the medium and/or the particles from the channels, and valves for setting the flow direction of the medium in the lines, the dielectrophoretically active channels being situated and being connected by lines in such a way that they may be operated connected in parallel and in series by switching the valves in relation to the flow direction of the medium and the electrodes of the various channels are activatable independently of one another.
    Type: Application
    Filed: January 6, 2014
    Publication date: May 1, 2014
    Applicant: ROBERT BOSCH GMBH
    Inventor: Christian DORRER
  • Publication number: 20140077315
    Abstract: An electronic sensor apparatus for detecting chemical or biological species includes a semiconductor chip, a sensor device, and a substrate. The chip is produced from a semiconductor substrate and is configured for one or more functions such as: amplifying and/or evaluating an electrical voltage, amplifying and/or evaluating an electric current, amplifying and/or evaluating an electrical charge, and amplifying and/or reading out capacitance changes. The sensor device has an active surface configured to detect chemical or biological species and generate an electrical signal based on a species-characteristic interaction with the active surface. The electrical signal can be an electrical voltage, an electric current, an electrical charge and/or a capacitance change. The substrate is produced from a melt-moldable material and has a surface including first and second regions. The chip is at least partly embedded in the first region, and the sensor device is at least partly embedded in the second region.
    Type: Application
    Filed: September 9, 2013
    Publication date: March 20, 2014
    Applicant: Robert Bosch GmbH
    Inventors: Georg Bischopink, Franz Laermer, Christian Dorrer, Thomas Brettschneider
  • Publication number: 20140045275
    Abstract: An apparatus for hermetically sealed storage of liquids for a microfluidic system includes at least one cavity and at least one sealing cone through which a connection to the microfluidic system is configured to be established and which closes the cavity.
    Type: Application
    Filed: December 28, 2011
    Publication date: February 13, 2014
    Applicant: Robert Bosch GmbH
    Inventors: Peter Rothacher, Christian Dorrer
  • Publication number: 20130186512
    Abstract: A microfluidic device has a chamber for storing a liquid. The chamber includes at least in part a hydrophobic surface on an internal wall.
    Type: Application
    Filed: July 24, 2012
    Publication date: July 25, 2013
    Applicant: Robert Bosch GmbH
    Inventor: Christian Dorrer
  • Publication number: 20130175213
    Abstract: A system for separating bodily fluid constituents is disclosed. The system includes a first substrate which, in a first main surface, has a first cavity for holding a bodily fluid sample, a second substrate, which, in a first main surface facing the first substrate, has a second cavity) for holding constituents separated from the bodily fluid sample, which second cavity lies opposite to the first cavity, a filter layer, which is arranged between the first substrate and the second substrate and which is designed to separate constituents of the bodily fluid sample in the first cavity and to pass the separated constituents to the second cavity, and a first thermoplastic connection layer, which is arranged between the first substrate and the filter layer, interconnects the first main surface of the first substrate and the filter layer in a fluid-tight manner and has a cutout lying opposite to the first cavity.
    Type: Application
    Filed: July 6, 2012
    Publication date: July 11, 2013
    Applicant: Robert Bosch GmbH
    Inventors: Christian Dorrer, Thomas Brettschneider
  • Publication number: 20130008511
    Abstract: A microfluidic device includes a first supply channel and a first discharge channel fluidically connected to one another by a first valve. The device also includes a second supply channel and a second discharge channel fluidically connected to one another by a second valve. At least one of the first channels can be fluidically connected to at least one of the second channels by a T-valve. The device also includes a control unit for controlling the valves, the control unit being configured in such a way that a first fluid from one of the first channels and a second fluid in one of the second channels can be laminated in parallel by actuating the valves in one of the first or second channels. A microfluidic system and a method for transporting fluids, and a use thereof are also disclosed.
    Type: Application
    Filed: July 4, 2012
    Publication date: January 10, 2013
    Applicant: Robert Bosch GmbH
    Inventors: Christian Dorrer, Jochen Rupp