Abstract: The present invention relates to mutated CSN5 polypeptides and their use in a method of screening modulators of CSN5 activity that could be used as therapeutic agents.

Abstract: The present invention relates to mutated CSN5 polypeptides and their use in a method of screening modulators of CSN5 activity that could be used as therapeutic agents.

Abstract: The present invention relates to mutated CSN5 polypeptides and their use in a method of screening modulators of CSN5 activity that could be used as therapeutic agents.

Abstract: Disposable hygiene pants with a front portion (2), a rear portion (3) and a crotch portion (4) provided with two leg openings (5, 6), the longitudinal edge portions (21, 22) of the front portion being connected by longitudinal weld seams (7, 8) to the longitudinal edge portions (31, 32) of the rear portion (3) in order to form a waist opening (9) and two leg openings (5, 6) in the crotch portion, which leg openings are outwardly delimited in the transverse direction by the inner end portions of the weld seams as seen in the longitudinal direction of the hygiene pants. The hygiene pants have an outer cover (10) and comprise an absorption unit (11). The cover is preferably made of an elastic laminate. The weld seams (7, 8) are each reinforced by at least one reinforcing strip (15, 16) containing thermoplastic fibers and have a tensile strength, in a direction transverse to the weld seam, in excess of 5 N/25.4 mm at least in the portions reinforced with said nonwoven strip (15, 16).

Abstract: Disposable hygiene pants with a front portion (2), a rear portion (3) and a crotch portion (4) provided with two leg openings (5, 6), the longitudinal edge portions (21, 22) of the front portion being connected by longitudinal weld seams (7, 8) to the longitudinal edge portions (31, 32) of the rear portion (3) in order to form a waist opening (9) and two leg openings (5, 6) in the crotch portion, which leg openings are outwardly delimited in the transverse direction by the inner end portions of the weld seams as seen in the longitudinal direction of the hygiene pants. The hygiene pants have an outer cover (10) and comprise an absorption unit (11). The cover is preferably made of an elastic laminate. The weld seams (7, 8) are each reinforced by at least one reinforcing strip (15, 16) containing thermoplastic fibers and have a tensile strength, in a direction transverse to the weld seam, in excess of 5 N/25.4 mm at least in the portions reinforced with said nonwoven strip (15, 16).

Abstract: Disposable hygiene pants with a front portion (2), a rear portion (3) and a crotch portion (4) provided with two leg openings (5, 6), the longitudinal edge portions (21, 22) of the front portion being connected by longitudinal weld seams (7, 8) to the longitudinal edge portions (31, 32) of the rear portion (3) in order to form a waist opening (9) and two leg openings (5, 6) in the crotch portion, which leg openings are outwardly delimited in the transverse direction by the inner end portions of the weld seams as seen in the longitudinal direction of the hygiene pants. The hygiene pants have an outer cover (10) and comprise an absorption unit (11). The cover is preferably made of an elastic laminate. The weld seams (7, 8) are each reinforced by at least one reinforcing strip (15, 16) containing thermoplastic fibers and have a tensile strength, in a direction transverse to the weld seam, in excess of 5 N/25.4 mm at least in the portions reinforced with said nonwoven strip (15, 16).

Abstract: Disposable hygiene pants with a front portion (2), a rear portion (3) and a crotch portion (4) provided with two leg openings (5, 6), the longitudinal edge portions (21, 22) of the front portion being connected by longitudinal weld seams (7, 8) to the longitudinal edge portions (31, 32) of the rear portion (3) in order to form a waist opening (9) and two leg openings (5, 6) in the crotch portion, which leg openings are outwardly delimited in the transverse direction by the inner end portions of the weld seams as seen in the longitudinal direction of the hygiene pants. The hygiene pants have an outer cover (10) and comprise an absorption unit (11). The cover is preferably made of an elastic laminate. The weld seams (7, 8) are each reinforced by at least one reinforcing strip (15, 16) containing thermoplastic fibers and have a tensile strength, in a direction transverse to the weld seam, in excess of 5 N/25.4 mm at least in the portions reinforced with said nonwoven strip (15, 16).