Patents by Inventor Christian Frauendorf

Christian Frauendorf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid linked to a trivalent glycoconjugate
    Patent number: 10913945
    Abstract: The present invention relates to a compound comprising a modified saccharide moiety conjugated to a nucleic acid. The compound is useful in medicine for RNA interference therapy or for research and diagnostic purposes. In particular, the compound is useful in treating liver disease.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: February 9, 2021
    Assignee: SILENCE THERAPEUTICS GMBH
    Inventors: Christian Frauendorf, Mark Cameron
  • NUCLEIC ACIDS FOR INHIBITING EXPRESSION OF A TARGET GENE COMPRISING PHOSPHORODITHIOATE LINKAGES
    Publication number: 20200392495
    Abstract: The present invention relates to products and compositions and their uses. In particular the invention relates to nucleic acid products that interfere with target gene expression or inhibit target gene expression and therapeutic uses of such products.
    Type: Application
    Filed: November 13, 2018
    Publication date: December 17, 2020
    Inventors: Lucas Bethge, Judith Hauptmann, Christian Frauendorf, Adrien Weingärtner
  • PRODUCTS AND COMPOSITIONS
    Publication number: 20200208158
    Abstract: The present invention relates to products and compositions and their uses. In particular the invention relates to nucleic acid products that interfere with the TMPRSS6 gene expression or inhibits its expression and therapeutic uses such as for the treatment of hemochromatosis, porphyria and blood disorders such as ?-thalassemias, sickle cell disease and transfusional iron overload or myelodysplastic syndrome.
    Type: Application
    Filed: April 5, 2018
    Publication date: July 2, 2020
    Applicant: Silence Therapeutics GmbH
    Inventors: Sibylle DAMES, Ute SCHAEPER, Judith HAUPTMANN, Christian FRAUENDORF, Lucas BETHGE, Adrien WEINGÄRTNER
  • PRODUCTS AND COMPOSITIONS
    Publication number: 20200095580
    Abstract: The present invention relates to products and compositions and their uses. In particular the invention relates to nucleic acid products that interfere with gene expression or inhibits its expression and therapeutic uses such as for the treatment of disease and disorders.
    Type: Application
    Filed: April 5, 2018
    Publication date: March 26, 2020
    Applicant: SILENCE THERAPEUTICS GMBH
    Inventors: Judith HAUPTMANN, Dmitry SAMARSKY, Christian FRAUENDORF
  • PRODUCTS AND COMPOSITIONS
    Publication number: 20200063133
    Abstract: The present invention relates to products and compositions and their uses. In particular the invention relates to nucleic acid products that interfere with target gene expression or inhibit target gene expression and therapeutic uses of such products.
    Type: Application
    Filed: April 5, 2018
    Publication date: February 27, 2020
    Inventors: Judith HAUPTMANN, Dmitry SAMARSKY, Adrien WEINGÄRTNER, Lucas BETHGE, Christian FRAUENDORF, Alison GALLAFENT
  • NUCLEIC ACID LINKED TO A TRIVALENT GLYCOCONJUGATE
    Publication number: 20190119676
    Abstract: The present invention relates to a compound comprising a modified saccharide moiety conjugated to a nucleic acid. The compound is useful in medicine for RNA interference therapy or for research and diagnostic purposes. In particular, the compound is useful in treating liver disease.
    Type: Application
    Filed: April 5, 2017
    Publication date: April 25, 2019
    Applicant: Silence Therapeutics GmbH
    Inventors: Christian FRAUENDORF, Mak CAMERON
  • PROCESS
    Publication number: 20140288299
    Abstract: The present invention relates to a process for preparing a short oligonucleotide comprising the steps of: (i) preparing a crude mixture comprising the oligonucleotide (ii) subjecting the mixture formed in step (i) to a desalting step; wherein the process does not comprise a chromatographic purification step.
    Type: Application
    Filed: July 25, 2011
    Publication date: September 25, 2014
    Applicant: SANTARIS PHARMA A/S
    Inventors: Michael Meldgaard, Marianne Mogensen, Christian Frauendorf, Christoph Rosenbohm
  • Immobilized nuckeic acids and uses thereof
    Publication number: 20050208487
    Abstract: One aspect of the present invention relates to an immobilized nucleic acid comprising a nucleic acid and a matrix where the nucleic acid is a Spiegelmer and the Spiegelmer is functionally active. Another aspect of the invention concerns an immobilized nucleic acid comprising a nucleic acid and a matrix where the nucleic acid is coupled to the matrix at least via its 3? end and the nucleic acid is a functional nucleic acid. Finally a further aspect of the invention concerns the use of such immobilized nucleic acids as affinity ligands for example in chromatography and in apheresis.
    Type: Application
    Filed: May 25, 2001
    Publication date: September 22, 2005
    Inventors: Jens Burmeister, Petra Burgstaller, Sven Klussmann, Thomas Klein, Christian Frauendorf
  • Allosteric ribozymes and uses thereof
    Publication number: 20030219422
    Abstract: The present invention is related to an allosteric (deoxy) ribozyme, wherein the ribozyme consists of L-nucleotides.
    Type: Application
    Filed: November 14, 2002
    Publication date: November 27, 2003
    Applicant: Noxxon Pharma AG
    Inventors: Christian Frauendorf, Sven Klussmann