Patents by Inventor Christian Freudiger
Christian Freudiger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11756675Abstract: A system is presented for analyzing and interpreting histologic images. The system includes an imaging device and a diagnostic module. The imaging device captures an image of a tissue sample at an optical section of the tissue sample, where the tissue sample has a thickness larger than the optical section. The system may further include an image interpretation subsystem located remotely from the imaging device and configured to receive the images from the imaging device. The diagnostic module is configured to receive the images for the tissue sample from the imaging device and generates a diagnosis for the tissue sample by applying a machine learning algorithm to the images. The diagnostic module may be interface directly with the imaging device or located remotely at the image interpretation subsystem.Type: GrantFiled: February 6, 2019Date of Patent: September 12, 2023Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.Inventors: Daniel Orringer, Balaji Pandian, Christian Freudiger, Todd Hollon
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Patent number: 11419590Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.Type: GrantFiled: August 14, 2020Date of Patent: August 23, 2022Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.Inventors: Daniel Orringer, Christian Freudiger, Jay Trautman, Andrew Kelly
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Publication number: 20210050094Abstract: A system is presented for analyzing and interpreting histologic images. The system includes an imaging device and a diagnostic module. The imaging device captures an image of a tissue sample at an optical section of the tissue sample, where the tissue sample has a thickness larger than the optical section. The system may further include an image interpretation subsystem located remotely from the imaging device and configured to receive the images from the imaging device. The diagnostic module is configured to receive the images for the tissue sample from the imaging device and generates a diagnosis for the tissue sample by applying a machine learning algorithm to the images. The diagnostic module may be interface directly with the imaging device or located remotely at the image interpretation subsystem.Type: ApplicationFiled: February 6, 2019Publication date: February 18, 2021Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.Inventors: Daniel ORRINGER, Balaji PANDIAN, Christian FREUDIGER, Todd HOLLON
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Publication number: 20200375580Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.Type: ApplicationFiled: August 14, 2020Publication date: December 3, 2020Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.Inventors: Daniel ORRINGER, Christian FREUDIGER, Jay TRAUTMAN, Andrew KELLY
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Patent number: 10743848Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.Type: GrantFiled: September 23, 2016Date of Patent: August 18, 2020Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.Inventors: Daniel Orringer, Christian Freudiger, Jay Trautman, Andrew Kelly
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Publication number: 20180263606Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.Type: ApplicationFiled: September 23, 2016Publication date: September 20, 2018Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.Inventors: Daniel ORRINGER, Christian FREUDIGER, Jay TRAUTMAN, Andrew KELLY
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Patent number: 9285575Abstract: A microscopy imaging system is disclosed that includes a light source system, a spectral shaper, a modulator system, an optics system, an optical detector and a processor. The light source system is for providing a first train of pulses and a second train of pulses. The spectral shaper is for spectrally modifying an optical property of at least some frequency components of the broadband range of frequency components such that the broadband range of frequency components is shaped producing a shaped first train of pulses to specifically probe a spectral feature of interest from a sample, and to reduce information from features that are not of interest from the sample. The modulator system is for modulating a property of at least one of the shaped first train of pulses and the second train of pulses at a modulation frequency.Type: GrantFiled: January 20, 2010Date of Patent: March 15, 2016Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Xiaoliang Sunney Xie, Christian Freudiger, Wei Min
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Patent number: 8721991Abstract: The present invention is directed to a device and method of controlling the phase separation of one or a mixture of two or more spider silk proteins, leading to the defined and controllable assembly of the said silk protein(s) to defined morphologies, such as spheres, nano fibrils, threads, etc.Type: GrantFiled: May 21, 2007Date of Patent: May 13, 2014Assignee: AMSilk GmbHInventors: Thomas Scheibel, Daniel Huemmerich, Sebastian Remmensee, Christian Freudiger, Andreas Bausch
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Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism
Patent number: 8027032Abstract: A microscopy imaging system includes a first light source for providing a first train of pulses at a first center optical frequency ?1, a second light source for providing a second train of pulses at a second center optical frequency ?2, a modulator system, an optical detector, and a processor. The modulator system is for modulating a beam property of the second train of pulses at a modulation frequency f of at least 100 kHz. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of the first train of pulses from the common focal volume by blocking the second train of pulses being modulated. The processor is for detecting, a modulation at the modulation frequency f, of the integrated intensity of the optical frequency components of the first train of pulses to provide a pixel of an image for the microscopy imaging system.Type: GrantFiled: August 22, 2008Date of Patent: September 27, 2011Assignee: President & Fellows of Harvard CollegeInventors: Xiaoliang Sunney Xie, Christian Freudiger, Wei Min -
Publication number: 20100188496Abstract: A microscopy imaging system is disclosed that includes a light source system, a spectral shaper, a modulator system, an optics system, an optical detector and a processor. The light source system is for providing a first train of pulses and a second train of pulses. The spectral shaper is for spectrally modifying an optical property of at least some frequency components of the broadband range of frequency components such that the broadband range of frequency components is shaped producing a shaped first train of pulses to specifically probe a spectral feature of interest from a sample, and to reduce information from features that are not of interest from the sample. The modulator system is for modulating a property of at least one of the shaped first train of pulses and the second train of pulses at a modulation frequency.Type: ApplicationFiled: January 20, 2010Publication date: July 29, 2010Inventors: Xiaoliang Sunney Xie, Christian Freudiger, Wei Min
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MICROSCOPY IMAGING SYSTEM AND METHOD EMPLOYING STIMULATED RAMAN SPECTROSCOPY AS A CONTRAST MECHANISM
Publication number: 20100046039Abstract: A microscopy imaging system is disclosed that includes a first light source, a second light source, a modulator system, focusing optics, an optical detector, and a processor. The first light source is for providing a first train of pulses at a first center optical frequency ?1. The second light source is for providing a second train of pulses at a second center optical frequency ?2 such that a difference between ?1 and ?2 is resonant with a vibrational frequency of a sample in the focal volume. The second train of pulses is temporally synchronized with the first train of pulses. The modulator system is for modulating a beam property of the second train of pulses at a modulation frequency f of at least 100 kHz. The focusing optics is for directing and focusing the first train of pulses and the second train of pulses toward a common focal volume.Type: ApplicationFiled: August 22, 2008Publication date: February 25, 2010Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Xiaoliang Sunney Xie, Christian Freudiger, Wei Min