Patents by Inventor Christian Freudiger

Christian Freudiger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210050094
    Abstract: A system is presented for analyzing and interpreting histologic images. The system includes an imaging device and a diagnostic module. The imaging device captures an image of a tissue sample at an optical section of the tissue sample, where the tissue sample has a thickness larger than the optical section. The system may further include an image interpretation subsystem located remotely from the imaging device and configured to receive the images from the imaging device. The diagnostic module is configured to receive the images for the tissue sample from the imaging device and generates a diagnosis for the tissue sample by applying a machine learning algorithm to the images. The diagnostic module may be interface directly with the imaging device or located remotely at the image interpretation subsystem.
    Type: Application
    Filed: February 6, 2019
    Publication date: February 18, 2021
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.
    Inventors: Daniel ORRINGER, Balaji PANDIAN, Christian FREUDIGER, Todd HOLLON
  • Publication number: 20200375580
    Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.
    Type: Application
    Filed: August 14, 2020
    Publication date: December 3, 2020
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.
    Inventors: Daniel ORRINGER, Christian FREUDIGER, Jay TRAUTMAN, Andrew KELLY
  • Patent number: 10743848
    Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: August 18, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.
    Inventors: Daniel Orringer, Christian Freudiger, Jay Trautman, Andrew Kelly
  • Publication number: 20180263606
    Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.
    Type: Application
    Filed: September 23, 2016
    Publication date: September 20, 2018
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.
    Inventors: Daniel ORRINGER, Christian FREUDIGER, Jay TRAUTMAN, Andrew KELLY
  • Patent number: 9285575
    Abstract: A microscopy imaging system is disclosed that includes a light source system, a spectral shaper, a modulator system, an optics system, an optical detector and a processor. The light source system is for providing a first train of pulses and a second train of pulses. The spectral shaper is for spectrally modifying an optical property of at least some frequency components of the broadband range of frequency components such that the broadband range of frequency components is shaped producing a shaped first train of pulses to specifically probe a spectral feature of interest from a sample, and to reduce information from features that are not of interest from the sample. The modulator system is for modulating a property of at least one of the shaped first train of pulses and the second train of pulses at a modulation frequency.
    Type: Grant
    Filed: January 20, 2010
    Date of Patent: March 15, 2016
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Xiaoliang Sunney Xie, Christian Freudiger, Wei Min
  • Patent number: 8721991
    Abstract: The present invention is directed to a device and method of controlling the phase separation of one or a mixture of two or more spider silk proteins, leading to the defined and controllable assembly of the said silk protein(s) to defined morphologies, such as spheres, nano fibrils, threads, etc.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: May 13, 2014
    Assignee: AMSilk GmbH
    Inventors: Thomas Scheibel, Daniel Huemmerich, Sebastian Remmensee, Christian Freudiger, Andreas Bausch
  • Patent number: 8027032
    Abstract: A microscopy imaging system includes a first light source for providing a first train of pulses at a first center optical frequency ?1, a second light source for providing a second train of pulses at a second center optical frequency ?2, a modulator system, an optical detector, and a processor. The modulator system is for modulating a beam property of the second train of pulses at a modulation frequency f of at least 100 kHz. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of the first train of pulses from the common focal volume by blocking the second train of pulses being modulated. The processor is for detecting, a modulation at the modulation frequency f, of the integrated intensity of the optical frequency components of the first train of pulses to provide a pixel of an image for the microscopy imaging system.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: September 27, 2011
    Assignee: President & Fellows of Harvard College
    Inventors: Xiaoliang Sunney Xie, Christian Freudiger, Wei Min
  • Publication number: 20100188496
    Abstract: A microscopy imaging system is disclosed that includes a light source system, a spectral shaper, a modulator system, an optics system, an optical detector and a processor. The light source system is for providing a first train of pulses and a second train of pulses. The spectral shaper is for spectrally modifying an optical property of at least some frequency components of the broadband range of frequency components such that the broadband range of frequency components is shaped producing a shaped first train of pulses to specifically probe a spectral feature of interest from a sample, and to reduce information from features that are not of interest from the sample. The modulator system is for modulating a property of at least one of the shaped first train of pulses and the second train of pulses at a modulation frequency.
    Type: Application
    Filed: January 20, 2010
    Publication date: July 29, 2010
    Inventors: Xiaoliang Sunney Xie, Christian Freudiger, Wei Min
  • Publication number: 20100046039
    Abstract: A microscopy imaging system is disclosed that includes a first light source, a second light source, a modulator system, focusing optics, an optical detector, and a processor. The first light source is for providing a first train of pulses at a first center optical frequency ?1. The second light source is for providing a second train of pulses at a second center optical frequency ?2 such that a difference between ?1 and ?2 is resonant with a vibrational frequency of a sample in the focal volume. The second train of pulses is temporally synchronized with the first train of pulses. The modulator system is for modulating a beam property of the second train of pulses at a modulation frequency f of at least 100 kHz. The focusing optics is for directing and focusing the first train of pulses and the second train of pulses toward a common focal volume.
    Type: Application
    Filed: August 22, 2008
    Publication date: February 25, 2010
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Xiaoliang Sunney Xie, Christian Freudiger, Wei Min