Abstract: Described herein are methods that define cellular populations that are sensitive to RARA agonists and identify patient populations that will benefit from treatment with RARA agonists. The methods may comprise administering RARA agonists to patient populations.

Abstract: Various methods and systems are provided for ultrasound imaging. In one embodiment, a method comprises acquiring, via an ultrasound probe, Doppler measurements over a plurality of cardiac cycles, evaluating a flow profile comprising the Doppler measurements to detect an abnormality in the flow profile, and displaying, via a display device, the flow profile with a reference flow profile overlaid thereon. In this way, the attention of a physician evaluating results from an ultrasound imaging examination may be directed to abnormal flow that is potentially indicative of pathologies, thereby enabling earlier and more accurate diagnosis of pathologies.

Abstract: A system and method for providing a guided workflow through a series of ultrasound image acquisitions with reference images updated based on a determined anatomical position is provided. The method includes acquiring and displaying, by an ultrasound system, at least one ultrasound image of an anatomy. The method includes determining, by at least one processor, a position of the anatomy depicted in the at least one ultrasound image. The method includes automatically selecting and displaying, by the at least one processor, reference images corresponding to pre-defined views of an ultrasound examination. An orientation of anatomy depicted in the selected and displayed reference images is based on the determined position of the anatomy. The method includes acquiring and displaying, by the ultrasound system, additional ultrasound images of the anatomy corresponding to the selected and displayed reference images. The additional ultrasound images include pre-defined views of the ultrasound examination.

Abstract: A Web-based system and method creates one or more qualitatively distinct process plans for machining a part. The surfaces of the part are modeled and parameters for a plurality of CNC machining tools are obtained, including the orientations along which the tool cuts away raw material. A maximal set of translations for each tool is also obtained, where each translation includes a collision-free orientation of the tool and a maximal machinable volume of material removable from the part in that orientation. A search engine navigates through a hierarchically-structured search space that starts at an initial state and transitions to successive states based on actions that satisfy a cost constraint function. Each state and each action includes a tool, orientation of the tool, and a maximal machinable volume. The search ends when a goal condition is satisfied. The actions constitute the process plan.

Abstract: Systems and methods are provided for enhanced heart medical imaging operations, particularly as by incorporating use of artificial intelligence (AI) based fetal heart functional analysis and/or real-time and automatic ejection fraction (EF) measurement and analysis.

Abstract: A hybridized rear axle drive (H-RAD) includes an electrical torque vectoring system (eTV) and a drive train for a motor vehicle, especially a plug-in hybrid vehicle (PHEV), and is configured to perform a method for electric torque distribution (electric torque vectoring).

Abstract: A mobile robot includes a mode of operation to recover from a localization error. The mobile robot detects a change in state in a local region proximate the mobile robot. The location of the mobile robot is identified based at least in part on the detected change in state. In one implementation, the mobile robot interfaces with a system controller of a building to initiate a change in state in a local region of a building.

Abstract: A system (e.g., an ultrasound imaging system) is provided. The system includes an ultrasound probe configured to acquire three-dimensional (3D) ultrasound data of a volumetric region of interest (ROI). The system further includes a display, a memory configured to store programmed instructions, and a controller circuit. The controller circuit includes one or more processors. The controller circuit is configured to execute the programmed instructions stored in the memory. When executing the programmed instructions, the controller circuit performs a plurality of operations. The operations includes collecting the 3D ultrasound data from an ultrasound probe and identifying a select set of the 3D ultrasound data corresponding to an object of interest within the volumetric ROI. The operations further include segmenting the object of interest from the select set of the 3D ultrasound data, generating a visualization plane of the object of interest, and displaying the visualization plane on the display.

Abstract: Automated fixture layout is approached in two distinct stages. First, the spatial locations of clamping points on the work piece are determined to ensure immobility of the fixtured part under any infinitesimal perturbation. Second, spatial locations are matched against a user-specified library of reconfigurable clamps to synthesize a valid fixture layout or configuration that includes clamps that are accessible and collision free. The spatial locations matching during the second stage can be the same spatial locations chosen in the first stage to ensure immobility, or a different set of spatial locations.

Abstract: Various methods and systems are provided for ultrasound imaging. In one embodiment, a method comprises acquiring, via an ultrasound probe, Doppler measurements over a plurality of cardiac cycles, evaluating a flow profile comprising the Doppler measurements to detect an abnormality in the flow profile, and displaying, via a display device, the flow profile with a reference flow profile overlaid thereon. In this way, the attention of a physician evaluating results from an ultrasound imaging examination may be directed to abnormal flow that is potentially indicative of pathologies, thereby enabling earlier and more accurate diagnosis of pathologies.

Abstract: Described herein are methods that define cellular populations that are sensitive to RARA agonists and identify patient populations that will benefit from treatment with RARA agonists. The methods may comprise administering RARA agonists to patient populations.

Abstract: Systems and methods are provided for enhanced heart medical imaging operations, particularly as by incorporating use of artificial intelligence (AI) based fetal heart functional analysis and/or real-time and automatic ejection fraction (EF) measurement and analysis.

Abstract: A system and method for assisting the identification of standard ultrasound scan planes based on M-mode analysis is provided. The method includes receiving and displaying an ultrasound scan plane of an anatomy. The method includes positioning one or more M-mode lines in the ultrasound scan plane. The method includes providing an M-mode trace for each of the one or more M-mode lines. The method includes providing feedback based on the M-mode trace for each of the one or more M-mode lines with reference to one or more characteristic trace patterns of a standard view. The method includes receiving and displaying an updated ultrasound scan plane of the anatomy manipulated in response to the feedback.

Abstract: Described herein are methods that define cellular populations that are sensitive to RARA agonists and identify patient populations that will benefit from treatment with RARA agonists. The methods may comprise administering RARA agonists to patient populations.

Abstract: A system and method for providing a guided workflow through a series of ultrasound image acquisitions with reference images updated based on a determined anatomical position is provided. The method includes acquiring and displaying, by an ultrasound system, at least one ultrasound image of an anatomy. The method includes determining, by at least one processor, a position of the anatomy depicted in the at least one ultrasound image. The method includes automatically selecting and displaying, by the at least one processor, reference images corresponding to pre-defined views of an ultrasound examination. An orientation of anatomy depicted in the selected and displayed reference images is based on the determined position of the anatomy. The method includes acquiring and displaying, by the ultrasound system, additional ultrasound images of the anatomy corresponding to the selected and displayed reference images. The additional ultrasound images include pre-defined views of the ultrasound examination.

Abstract: An ultrasound device performs a two-dimensional (2D) ultrasound scan to acquire a plurality of 2D images based on 2D ultrasound scan parameters. The ultrasound system stops the 2D ultrasound scan in response to an instruction received by a processor of the ultrasound system. The ultrasound device performs a thin slice volume ultrasound scan in response to the instruction to acquire a thin slice volume. The thin slice volume includes a last acquired 2D image of the 2D ultrasound scan and one or more 2D images adjacent to the last acquired 2D image. The ultrasound system identifies at least one representative plane from the thin slice volume. The ultrasound system displays the identified at least one representative plane at a display system.

Abstract: A system and method for optimization of on-demand microtransit is provided. A list of possible stops of one or more vehicles is maintained. A plurality of requests for transportation are received, each of the requests associated with at least one traveler. Travelers to be transported by one of the vehicles are selected. A set of a minimal number of the stops is selected, the set comprising at least one stop that is within a predefined walking distance of the origin location of each of the selected travelers and at least one stop within the predefined walking distance of the destination location of each of the selected travelers. Potential routes are identified for the vehicle that include the stops in the set. The potential routes are evaluated using a plurality of constraints and one of the routes is selected for fulfilling the requests of the selected travelers.

Abstract: Automated fixture layout is approached in two distinct stages. First, the spatial locations of clamping points on the work piece are determined to ensure immobility of the fixtured part under any infinitesimal perturbation. Second, spatial locations are matched against a user-specified library of reconfigurable clamps to synthesize a valid fixture layout or configuration that includes clamps that are accessible and collision free. The spatial locations matching during the second stage can be the same spatial locations chosen in the first stage to ensure immobility, or a different set of spatial locations.

Abstract: A method includes displaying a cursor on a display device with a computer system, and concurrently receiving first and second user inputs associated with movement of the cursor on the display device via the computer system. The method also includes moving display of the cursor on the display device in a vector defined by the first and second user inputs. The first user input defines a direction in which the cursor is moved on the display device and the second user input defines a speed at which the cursor is moved on the display device.

Abstract: A mobile robot includes a mode of operation to recover from a localization error. The mobile robot detects a change in state in a local region proximate the mobile robot. The location of the mobile robot is identified based at least in part on the detected change in state. In one implementation, the mobile robot interfaces with a system controller of a building to initiate a change in state in a local region of a building.