Patents by Inventor Christian Gert Bluchel
Christian Gert Bluchel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11590272Abstract: There is provided a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a layer of immobilized uremic toxin-treating enzyme particles intermixed with cation exchange particles.Type: GrantFiled: February 17, 2020Date of Patent: February 28, 2023Assignee: TEMASEK POLYTECHNICInventors: Christian Gert Bluchel, Yanmei Wang, Kim Cheng Tan
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Publication number: 20220401634Abstract: The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.Type: ApplicationFiled: August 22, 2022Publication date: December 22, 2022Inventors: Christian Gert Bluchel, Peter Haywood
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Patent number: 11458235Abstract: The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.Type: GrantFiled: December 5, 2017Date of Patent: October 4, 2022Assignees: TEMASEK POLYTECHNIC, AWAK TECHNOLOGIES PTE LTDInventors: Christian Gert Bluchel, Peter Haywood
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Patent number: 11135347Abstract: The present disclosure relates to dialysis devices. In some embodiments, a dialysis device may include a disposable housing having a storage chamber in fluid communication with a dialysate flow path. Also included may be a controller, an interface capable of operably coupling the controller and the disposable housing, a fluid displacement structure, a pump configured to actuate a deformable diaphragm, and a pressure sensor to trigger the reversal of the pump. The flow path may be fluidly sealed from the controller and the interface.Type: GrantFiled: November 30, 2017Date of Patent: October 5, 2021Assignee: Temasek PolytechnicInventors: Christian Gert Bluchel, Liutong Lin
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Publication number: 20210205522Abstract: A dialysis device is provided including a disposable housing having a flow path along which dialysate received from a patient is subjected to contaminant removal when in operation. The device includes a controller for controlling the operation of the disposable housing and an interface capable of operably coupling the controller and the disposable housing to enable the contaminant removal from the dialysate. The flow path is fluidly sealed from the controller and interface.Type: ApplicationFiled: March 23, 2021Publication date: July 8, 2021Applicant: TEMASEK POLYTECHNICInventors: Christian Gert Bluchel, Liutong Lin
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Publication number: 20200179589Abstract: There is provided a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a layer of immobilized uremic toxin-treating enzyme particles intermixed with cation exchange particles.Type: ApplicationFiled: February 17, 2020Publication date: June 11, 2020Inventors: Christian Gert BLUCHEL, Yanmei WANG, Kim Cheng TAN
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Publication number: 20200078507Abstract: The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.Type: ApplicationFiled: December 5, 2017Publication date: March 12, 2020Inventors: Christian Gert Bluchel, HAYWOOD Peter
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Patent number: 10018607Abstract: A sensing system for detecting a substance in a dialysate. The system includes a hydrophobic barrier capable of allowing the substance in the dialysate to equilibrate through the barrier to a gas. The system also includes a detector capable of detecting the gas and an interface disposed between the hydrophobic barrier and the detector and configured to allow transport of the gas between the hydrophobic barrier and the detector following a concentration gradient of the gas along the interface.Type: GrantFiled: August 24, 2015Date of Patent: July 10, 2018Assignees: Temasek Polytechnic, AWAK TECHNOLOGIES PTE. LTD.Inventors: Christian Gert Bluchel, Yanmei Wang, Hua Zhang, Jui Pin Er, Kim Jyh Wong
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Publication number: 20180147338Abstract: The present disclosure relates to dialysis devices. In some embodiments, a dialysis device may include a disposable housing having a storage chamber in fluid communication with a dialysate flow path. Also included may be a controller, an interface capable of operably coupling the controller and the disposable housing, a fluid displacement structure, a pump configured to actuate a deformable diaphragm, and a pressure sensor to trigger the reversal of the pump. The flow path may be fluidly sealed from the controller and the interface.Type: ApplicationFiled: November 30, 2017Publication date: May 31, 2018Applicant: TEMASEK POLYTECHNICInventors: Christian Gert Bluchel, Liutong Lin
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Publication number: 20160151555Abstract: There is provided a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a layer of immobilized uremic toxin-treating enzyme particles intermixed with cation exchange particles.Type: ApplicationFiled: December 29, 2015Publication date: June 2, 2016Inventors: Christian Gert BLUCHEL, Yanmei WANG, Kim Cheng TAN
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Publication number: 20160109421Abstract: A sensing system for detecting a substance in a dialysate. The system includes a hydrophobic barrier capable of allowing the substance in the dialysate to equilibrate through the barrier to a gas. The system also includes a detector capable of detecting the gas and an interface disposed between the hydrophobic barrier and the detector and configured to allow transport of the gas between the hydrophobic barrier and the detector following a concentration gradient of the gas along the interface.Type: ApplicationFiled: August 24, 2015Publication date: April 21, 2016Applicant: TEMASEK POLYTECHNICInventors: Christian Gert Bluchel, Yanmei Wang, Hua Zhang, Jui Pin Er, Kim Jyh Wong
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Patent number: 9242036Abstract: There is provided a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a layer of immobilized uremic toxin-treating enzyme particles intermixed with cation exchange particles.Type: GrantFiled: June 22, 2009Date of Patent: January 26, 2016Assignee: TEMASEK POLYTECHNICInventors: Christian Gert Bluchel, Yanmei Wang, Kim Cheng Tan
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Patent number: 9138524Abstract: A sensing system for detecting a substance in a dialysate. The system includes a hydrophobic barrier capable of allowing the substance in the dialysate to equilibrate to a gas; a detector capable of detecting the gas; an interface disposed between the hydrophobic barrier and the detector and configured to allow fluid communication of the gas; and one or more delivery mechanisms capable of transporting the gas from the hydrophobic barrier to the detector. A method of detecting ammonium gas in a dialysate is also provided.Type: GrantFiled: November 8, 2012Date of Patent: September 22, 2015Assignee: Temasek PolytechnicInventors: Christian Gert Bluchel, Yanmei Wang, Hua Zhang, Jui Pin Er, Kim Jyh Wong
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Patent number: 9067017Abstract: There is provided a flow system of a dialysis device including a dialysate conduit which is capable of being in fluid communication with the peritoneal cavity of a patient's body and of being in fluid communication with a flow path, the flow path allowing dialysate to flow from a patient's body to a sorbent capable of removing contaminants within the dialysate in an outflow mode and in an inflow mode returning the dialysate substantially free of contaminants to the patient's body. The device also includes a pump for moving the dialysate along the flow path in both the outflow mode and inflow mode and a plurality of valves disposed along the flow path. There is also provided a portable dialysis device.Type: GrantFiled: June 22, 2009Date of Patent: June 30, 2015Assignee: TEMASEK POLYTECHNICInventors: Kim Cheng Tan, Christian Gert Bluchel, Lay Leng Chew, Kee Kiat Chua, Lai Ching Helen Ho, Keng Hong Lee, Liutong Lin, Weng Cheong Roy Tang, Keng Mun Yue, Kim Jyh Wong, Cheng Lam Chua
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Publication number: 20140309584Abstract: A dialysis device is provided comprising a disposable housing having a dialysate flow path along which dialysate received from a patient is subjected to contaminant removal when in operation, wherein said disposable housing comprises a storage chamber in fluid communication with the dialysate flow path for storing the dialysate therein; a controller for controlling the operation of said disposable housing; an interface means capable of operably coupling the controller and the disposable housing to enable the contaminant removal from the dialysate, and a fluid displacement means configured to move the dialysate along the dialysate flow path, wherein said fluid displacement means comprises a deformable diaphragm integrally formed with at least one wall of said storage chamber, wherein the flow path is fluidly sealed from the controller and interface means. A method of dialysis, a dialysis system and kits are also provided.Type: ApplicationFiled: November 8, 2011Publication date: October 16, 2014Applicant: Temasek PolytechnicInventors: Christian Gert Bluchel, Liutong Lin
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Publication number: 20140291218Abstract: A sensing system for detecting a substance in a dialysate. The system includes a hydrophobic barrier capable of allowing the substance in the dialysate to equilibrate to a gas; a detector capable of detecting the gas; an interface disposed between the hydrophobic barrier and the detector and configured to allow fluid communication of the gas; and one or more delivery mechanisms capable of transporting the gas from the hydrophobic barrier to the detector. A method of detecting ammonium gas in a dialysate is also provided.Type: ApplicationFiled: November 8, 2012Publication date: October 2, 2014Applicant: Temasek PolytechnicInventors: Christian Gert Bluchel, Yanmei Wang, Hua Zhang, Jui Pin Er, Kim Jyh Wong
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Publication number: 20140017761Abstract: A substrate having compounds disposed thereon for immobilizing a functional molecule, each compound having a chain including: a moiety R that is chemically coupled to the substrate, the moiety R being selected from the group consisting of an ether, ester, carbonyl, carbonate ester, thioether, disulfide, sulfinyl, sulfonyl, and carbonothioyl; and an epoxide-containing moiety that is coupled to the moiety R by a linker including at least one nucleophilic group. Methods of preparing the substrate and use of the substrate are also disclosed.Type: ApplicationFiled: September 18, 2013Publication date: January 16, 2014Applicant: TEMASEK POLYTECHNICInventors: Christian Gert BLUCHEL, Yanmei WANG
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Patent number: 8561811Abstract: A substrate having compounds disposed thereon for immobilizing a functional molecule, each compound having a chain including: a moiety R that is chemically coupled to the substrate, the moiety R being selected from the group consisting of an ether, ester, carbonyl, carbonate ester, thioether, disulfide, sulfinyl, sulfonyl, and carbonothioyl; and an epoxide-containing moiety that is coupled to the moiety R by a linker including at least one nucleophilic group. Methods of preparing the substrate and use of the substrate are also disclosed.Type: GrantFiled: March 15, 2013Date of Patent: October 22, 2013Assignee: Temasek PolytechnicInventors: Christian Gert Bluchel, Yanmei Wang
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Publication number: 20130210111Abstract: A substrate having compounds disposed thereon for immobilizing a functional molecule, each compound having a chain including: a moiety R that is chemically coupled to the substrate, the moiety R being selected from the group consisting of an ether, ester, carbonyl, carbonate ester, thioether, disulfide, sulfinyl, sulfonyl, and carbonothioyl; and an epoxide-containing moiety that is coupled to the moiety R by a linker including at least one nucleophilic group.Type: ApplicationFiled: March 15, 2013Publication date: August 15, 2013Applicant: TEMASEK POLYTECHNICInventors: Christian Gert BLUCHEL, Yanmei WANG
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Publication number: 20110184340Abstract: There is provided a flow system of a dialysis device including a dialysate conduit which is capable of being in fluid communication with the peritoneal cavity of a patient's body and of being in fluid communication with a flow path, the flow path allowing dialysate to flow from a patient's body to a sorbent capable of removing contaminants within the dialysate in an outflow mode and in an inflow mode returning the dialysate substantially free of contaminants to the patient's body. The device also includes a pump for moving the dialysate along the flow path in both the outflow mode and inflow mode and a plurality of valves disposed along the flow path. There is also provided a portable dialysis device.Type: ApplicationFiled: June 22, 2009Publication date: July 28, 2011Inventors: Kim Cheng Tan, Christian Gert Bluchel, Lay Leng Chew, Kee Kiat Chua, Lai Ching Helen Ho, Keng Hong Lee, Liutong Lin, Weng Cheong Roy Tang, Keng Mun Yue, Kim Jyh Wong, Cheng Lam Chua