Abstract: Provided herein are methods for culturing cells, including stimulating or expanding (proliferating), a plurality of cells in a composition of cells such as a population of lymphocytes. In some aspects, provided methods and reagents for the culturing, such as stimulation or expansion (proliferation), of cell populations involve binding of agents to a molecule on the surface of the cells, thereby providing one or more signals to the cells. In some cases, the reagents are multimerization reagents and the one or more agents are multimerized by reversibly binding to the reagent. In some aspects, the multimerized agent can provide for expansion or proliferation or other stimulation of a population of cells, and then such stimulatory agents can be removed by disruption of the reversible bond. Also provided are compositions, apparatus and methods of use thereof.

Abstract: A method for controlling a robot for manipulating, in particular picking up, an object. The method includes: creating an image which depicts the object; generating a manipulation-quality image from the image, in which, for each pixel which represents a point on the surface of the object, the pixel value of the pixel provides an assessment of how well the object may be manipulated at the point; recording descriptors of points of the object which should be used during the manipulation and/or of points which should be avoided during the manipulation; mapping the image onto a descriptor image; generating a manipulation-preference image by comparing the recorded descriptors of points to the descriptor image; selecting a point for manipulating the object taking into account the pixel values of the manipulation-quality image and the pixel values of the manipulation-preference image; and controlling the robot to manipulate the object at the selected point.

Abstract: A brush manufacturing device (1) for feeding tufts of bristles (2) to receiving openings (3) in a target plate (4) is provided, The device includes at least one sensor (7). The sensor allows to monitor the force which a sliding drive (5) of the device (1) applies to at least one sliding pin (6) of the device (1).

Abstract: A method for operating a motor vehicle, the motor vehicle has a control device and a drive train. The drive train includes as components a motor, a clutch, and at least one wheel. The motor is coupled to the at least one wheel via the clutch. The control device controls a rotational speed of the at least one wheel based on a rotational speed specification using a model mapping the drive train of the motor vehicle. A torque generated by the motor is influenced as the manipulated variable as a function of at least one state variable of the drive train determined on the basis of the model.

Abstract: A method for training a machine learning model for generating descriptor images for images of one or more objects. The method includes recording multiple camera images, each showing one or more objects, and, for each camera image, generating one or more augmented versions of the camera image by applying a respective augmentation to the camera image for each augmented version of the camera image, wherein the augmentation comprises a change in position of pixel values of the camera image, generating pairs of training images each including the camera image and an augmentation of the camera image or two augmented versions of the camera image; and training the machine learning model with contrastive loss using the pairs of training images.

Abstract: Despite the abundance of scandium, its commercial applications continue to be limited by the absence of reliable, secure, stable and long-term production. The subject-matter disclosed herein provides for a method for extracting Rare Earth Elements (REE), scandium and/or Rare-Earth Oxides (REO) from ore and mineral concentrates, the method comprising: providing Rare Earth Elements (REE) and/or scandium bearing feedstock; a high-pressure caustic (HPC) leaching step, comprising leaching the feedstock in an alkali solution at a first temperature for a target period of time and at a given pressure to produce a leachate slurry; extracting a solid residue from the leachate slurry; leaching of the solid residue in a mineral acid to form a primary leach solution; extracting scandium and/or REE from the primary leach solution; and/or precipitating REE remaining in the raffinate to form a mixed REE-carbonate to thereby facilitate the extraction of REO.

Abstract: An all-wheel system for a motor vehicle, with a first electric machine for driving a first drive axle of the motor vehicle; a first electronic power unit for controlling a rotational speed of the first electric machine; a second electric machine for driving a second drive axle of the motor vehicle; a second electronic power unit for controlling the rotational speed of the second electric machine on the basis of the rotational speed of the first electric machine and a specified differential rotational speed between the first electric machine and the second electric machine.

Abstract: A method for regulating a drive train of a motor vehicle. The drive train includes, as components, a motor, at least one mechanical component, and at least one wheel. The motor is coupled to the at least one wheel via the at least one mechanical component. A speed of the at least one component of the drive train based on a speed specification is regulated using a model depicting the drive train of the motor vehicle. A torque generated by the motor is influenced as a regulated variable as a function of at least one state variable of the drive train determined on the basis of the model.

Abstract: A method for regulating a drive train of a motor vehicle. The drive train includes, as components, a motor, at least one mechanical component, and at least one wheel. The motor is coupled to the at least one wheel via the at least one mechanical component. A speed of the at least one component of the drive train based on a speed specification is regulated using a model depicting the drive train of the motor vehicle. A torque generated by the motor is influenced as a regulated variable as a function of at least one state variable of the drive train determined on the basis of the model.

Abstract: A method for operating a motor vehicle, the motor vehicle has a control device and a drive train. The drive train includes as components a motor, a clutch, and at least one wheel. The motor is coupled to the at least one wheel via the clutch. The control device controls a rotational speed of the at least one wheel based on a rotational speed specification using a model mapping the drive train of the motor vehicle. A torque generated by the motor is influenced as the manipulated variable as a function of at least one state variable of the drive train determined on the basis of the model.

Abstract: An identity of an email-address utilized by a client device is verified. According to one example, a server receives a request for verifying the identity of the email-address and calculates a first verification token, which is transmitted to the email address to be verified. The first verification token is received by the client device, which in response calculates a second verification token. The second verification token is transmitted to the server. The server verifies the identity of the email-address by verifying that the first and second verification tokens are identical. Other examples are disclosed.

Abstract: A method for operating a clutch of a drive train of a vehicle wherein the clutch, a drive motor primary axis having first wheels that can be driven by the drive motor as first axis and a second axis having second wheels are driven by the drive motor via the clutch as second axis, with the clutch being adjusted between a closed position, wherein a first coupling torque of the clutch is set, and at least one second position differing from the closed position, wherein a second coupling torque of the clutch that is lower than the first coupling torque is set: determining at least one coefficient of friction of a roadway the vehicle is located on; and as a factor of the determined coefficient of friction: adjusting a basic torque of the clutch, with the clutch being prestressed in the second position by the basic torque.

Abstract: A method for operating a clutch of a drive train of a vehicle wherein the clutch, a drive motor primary axis having first wheels that can be driven by the drive motor as first axis and a second axis having second wheels are driven by the drive motor via the clutch as second axis, with the clutch being adjusted between a closed position, wherein a first coupling torque of the clutch is set, and at least one second position differing from the closed position, wherein a second coupling torque of the clutch that is lower than the first coupling torque is set: determining at least one coefficient of friction of a roadway the vehicle is located on; and as a factor of the determined coefficient of friction: adjusting a basic torque of the clutch, with the clutch being prestressed in the second position by the basic torque.

Abstract: Selective removal of erroneous nucleic acids or the selective retrieval of correct nucleic acids is enabled by controlled complementary strand synthesis using compositions of nucleotides at each cycle of the synthesis that facilitate the extension of correctly templated complementary strands and the termination of incorrectly templated complementary strands to the effect of allowing sufficient biochemical discrimination between correct and erroneous nucleic acids, for example, based on the completeness of the complementary strand synthesis.

Abstract: An apparatus for utilizing waste heat of an internal combustion engine includes an exhaust gas manifold and a thermoelectric element. The thermoelectric element is configured to generate an electric voltage as a result of a temperature difference between a side facing away from the exhaust gas manifold and an opposite side. The thermoelectric element is arranged on the exhaust gas manifold. The apparatus additionally includes a cooling element arranged on the thermoelectric element on the side facing away from the exhaust gas manifold. The cooling element has at least one cooling passage configured to provide for the throughflow of a fluid.

Abstract: The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc-mutated derivatives of two different monoclonal antibodies in mammalian cell lines.

Abstract: An all-wheel system for a motor vehicle, with a first electric machine for driving a first drive axle of the motor vehicle; a first electronic power unit for controlling a rotational speed of the first electric machine; a second electric machine for driving a second drive axle of the motor vehicle; a second electronic power unit for controlling the rotational speed of the second electric machine on the basis of the rotational speed of the first electric machine and a specified differential rotational speed between the first electric machine and the second electric machine.

Abstract: An endoscope or exoscope having a shaft and at least one objective and at least one electronic image recorder for recording an image of an object field, wherein the objective and image recorder are arranged in a distal end region of the endoscope or exoscope, and includes at least one cable, routed within the endoscope or exoscope, for supply of and/or image transmission from the electronic image recorder, wherein the electronic image recorder includes an optical unit, which is rotatable about a first axis of rotation identical or approximately parallel to a direction of view of the scope, and on which the cable is connected and can be wound on a circumferential surface of the optical unit, and wherein the distal end region includes a cavity, in which storage for holding a section of the cable is held.

Abstract: An identity of an email-address utilized by a client device is verified. According to one example, a server receives a request for verifying the identity of the email-address and calculates a first verification token, which is transmitted to the email address to be verified. The first verification token is received by the client device, which in response calculates a second verification token. The second verification token is transmitted to the server. The server verifies the identity of the email-address by verifying that the first and second verification tokens are identical. Other examples are disclosed.