Patents by Inventor Christian Hakemeyer

Christian Hakemeyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Infrared and fluorescence spectroscopic finger-printing of raw materials for use in the cultivation of a mammalian cell expressing a protein of interest
    Patent number: 10816477
    Abstract: The invention provides a method for the selection of cultivation component batches to be used in the cultivation of a mammalian cell expressing a protein of interest wherein at least two different components are employed in the cultivation.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: October 27, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jose Cardoso-Menezes, Christian Hakemeyer, Gledson Emidio Jose, Ulrike Strauss, Silke Werz
  • SPECTROSCOPIC FINGER-PRINTING OF RAW MATERIALS
    Publication number: 20180202938
    Abstract: The invention provides a method for the selection of cultivation component batches to be used in the cultivation of a mammalian cell expressing a protein of interest wherein at least two different components are employed in the cultivation.
    Type: Application
    Filed: September 22, 2017
    Publication date: July 19, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jose Cardoso-Menezes, Christian Hakemeyer, Gledson Emidio Jose, Ulrike Strauss, Silke Werz
  • Method for purifying polypeptide solutions
    Patent number: 9884904
    Abstract: Herein is reported a method for purifying cell cultivation supernatants either directly after fermentation or after one or more preliminary purification steps, such as protein A affinity chromatography. By adjusting the pH value in the acid range and subsequent incubation of the acidified solution host cell nucleic acid and host cell protein can be precipitated but the target polypeptide remains in solution. Thereafter the precipitate and therewith the contaminating host cell components can be removed by a simple physical separation step.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: February 6, 2018
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Vinzenz Binder, Christian Hakemeyer, Felizitas Schwarz
  • METHOD FOR PURIFYING POLYPEPTIDE SOLUTIONS
    Publication number: 20130005948
    Abstract: Herein is reported a method for purifying cell cultivation supernatants either directly after fermentation or after one or more preliminary purification steps, such as protein A affinity chromatography. By adjusting the pH value in the acid range and subsequent incubation of the acidified solution host cell nucleic acid and host cell protein can be precipitated but the target polypeptide remains in solution. Thereafter the precipitate and therewith the contaminating host cell components can be removed by a simple physical separation step.
    Type: Application
    Filed: March 9, 2011
    Publication date: January 3, 2013
    Inventors: Vinzenz Binder, Christian Hakemeyer, Felizitas Schwarz