Abstract: The invention features a method for identifying a gene associated with a desired phenotype. This method includes the steps of: (a) providing a plurality of cell cultures that include plant, animal, or fungal cells capable of exhibiting a desired phenotype; (b) contacting each of at least a subset of said cells with a stimulus that (i) induces said cells to exhibit the phenotype, or (ii) does not induce said cell cultures to exhibit the phenotype; (c) determining the presence of the phenotype in the cell cultures of step (b); and (d) identifying a gene having increased expression in response to stimuli that induce the phenotype but do not have increased expression in response to stimuli that do not induce the phenotype.

Abstract: The invention features a method for identifying a gene associated with a desired phenotype. This method includes the steps of: (a) providing a plurality of cell cultures that include plant, animal, or fungal cells capable of exhibiting a desired phenotype; (b) contacting each of at least a subset of said cells with a stimulus that (i) induces said cells to exhibit the phenotype, or (ii) does not induce said cell cultures to exhibit the phenotype; (c) determining the presence of the phenotype in the cell cultures of step (b); and (d) identifying a gene having increased expression in response to stimuli that induce the phenotype but do not have increased expression in response to stimuli that do not induce the phenotype.

Abstract: This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, antiproliferatives, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Further provided are methods of using the site-specific supplemented tissue sealants, including preparation of a biomaterial.

Abstract: This invention provides supplemented tissue sealants, methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one cytotoxin or cell proliferation inhibiting composition. The composition may be further supplemented with, for example, one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial compositions, cytokines, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like.