Abstract: A data collection device comprises: a first portion having one or more features configured for attaching of the first portion to a dosage knob of an injection device; a second portion rotatably coupled with the first portion, wherein at least part of the second portion is movable axially relative to the first portion; a sensor arrangement configured to detect rotation of the first portion relative to the second portion; and a processor arrangement configured to, based on said detected movement, determine a medicament amount expelled by the injection device, wherein the coupling arrangement is configured to provide a non-permanent coupling between the first portion and the dosage knob of the injection device.

Abstract: A data collection device comprises: a first portion having one or more features configured for attaching of the first portion to a dosage knob of an injection device; a second portion rotatably coupled with the first portion, wherein at least part of the second portion is movable axially relative to the first portion; a sensor arrangement configured to detect rotation of the first portion relative to the second portion; and a processor arrangement configured to, based on said detected movement, determine a medicament amount expelled by the injection device, wherein the coupling arrangement is configured to provide a non-permanent coupling between the first portion and the dosage knob of the injection device.

Abstract: An optoelectronic device may include an optoelectronic semiconductor chip that is configured to emit electromagnetic radiation. The chip may include a first semiconductor layer, a second semiconductor layer, first and second current spreading structures, and a plurality of electrical contact elements. The first current spreading layer may be arranged on a side of the second semiconductor layer facing away from the first semiconductor layer. The plurality of electrical contact elements may electrically connect the first semiconductor layer to the first current spreading layer. The second current spreading layer may be electrically connected to the second semiconductor layer. The second current spreading layer may be arranged between the first current spreading layer and the second semiconductor layer where an insulating layer insulates a first electrical contact element and a second electrical contact element from the second current spreading layer.

Abstract: Systems and methods are provided for computing user scores or ratings for an application program. The method comprises receiving a survey request from a scoring computer system and providing multiple instances of a survey template to a plurality of end-user-computers. A scoring computer system receives survey data from the plurality of end-user-computers and sends the survey data to the scoring computer system. The survey data is free of data allowing identification of individual end-users or end-user-computers. The scoring computer system computes a user experience score for the one application program as a function of the survey data and outputs a graphical representation of the computed score by the scoring computer system. The survey data is provided in a structure defined by one template, which allows the user experience of all end-users to be comparable.

Abstract: The present invention relates to novel compounds as new chemical entities with thymine skeleton, these compounds for use as in medicine, especially in the treatment of carcinoma, HSP27-associated diseases and cystic fibrosis; and a pharmaceutical product containing at least one of these compounds. Finally, a method of production of that novel compounds is presented. General formula of these compounds is formula (I): as further defined in claim 1.

Abstract: An ultrasound probe comprises an air chamber unit that includes a transducer slot, where the transducer slot is configured to receive a transducer assembly, the air chamber unit comprises at least one sealed cavity and each of the at least one sealed cavity is filled with one or more gases, and the transducer assembly comprises transducer elements configured to perform one or both of transmitting and receiving acoustic energy.

Abstract: The present invention relates to novel compounds as new chemical entities with thymine skeleton, these compounds for use as in medicine, especially in the treatment of carcinoma, HSP27-associated diseases and cystic fibrosis; and a pharmaceutical product containing at least one of these compounds. Finally, a method of production of that novel compounds is presented. General formula of these compounds is formula (I): as further defined in claim 1.

Abstract: The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.

Abstract: A switch, in particular a grounding switch, is for quickly establishing a ground connection and for extinguishing an arc fault for a switching system. The grounding switch includes at least one fixed contact having a first cable feed, a moving contact, a contact guide having a second cable feed, and a mechanical energy store. In the opened state, an insulating distance between the fixed contact and the moving contact, is filled with insulation liquid, at least in part. The switch further includes a triggering device and a locking mechanism.

Abstract: A device for analyzing and/or generating a polarization state of a measurement point of a target object includes a polarizer suitable for selecting, in an incident light wave, a light beam which is linearly polarized in a predefined direction; a first birefringent element suitable for having the light beam pass therethrough; a second birefringent element identical to the first element and suitable for having the light beam pass therethrough, the light beam then being directly or indirectly directed toward the object in order to be reflected in the form of a reflected beam. The device includes an optical assembly having one or more optical elements located in an optical path between the first element and the second element, and the optical assembly includes an odd number of mirrors, or, an odd number of half-wave plates, or, an odd number of a mix of mirrors and half-wave plates.

Abstract: The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.

Abstract: A switch, in particular a grounding switch, is for quickly establishing a ground connection and for extinguishing an arc fault for a switching system. The grounding switch includes at least one fixed contact having a first cable feed, a moving contact, a contact guide having a second cable feed, and a mechanical energy store. In the opened state, an insulating distance between the fixed contact and the moving contact, is filled with insulation liquid, at least in part. The switch further includes a triggering device and a locking mechanism.

Abstract: The present invention relates to novel HSP27 inhibitors, in particular purine derivatives according to general formula (I) or (II) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP2.

Abstract: A device for analyzing and/or generating a polarization state of a measurement point of a target object includes a polarizer suitable for selecting, in an incident light wave, a light beam which is linearly polarized in a predefined direction; a first birefringent element suitable for having the light beam pass therethrough; a second birefringent element identical to the first element and suitable for having the light beam pass therethrough, the light beam then being directly or indirectly directed toward the object in order to be reflected in the form of a reflected beam. The device includes an optical assembly having one or more optical elements located in an optical path between the first element and the second element, and the optical assembly includes an odd number of mirrors, or, an odd number of half-wave plates, or, an odd number of a mix of mirrors and half-wave plates.

Abstract: A system for producing tactile images from a drawing or graphics file includes an image scanner or input device for importing and creating a digital file, which may be operated upon by software in a computer. The software has edge detection and color detection functions that may be adjusted to create an image file that may be provided to an embossing machine, which in turn prints a tactile image.

Abstract: Disclosed are uracil derivatives of the formula (I): wherein R1, R2, R3, and X are as defined herein, and use thereof as therapeutic agents. The uracil derivatives are used in particular together with a cytostatic agent for suppressing or reducing resistance building up on cytostatic treatment.

Abstract: Methods and systems for connection to a transducer in ultrasound probes are provided. One connection arrangement includes a connector having a transducer connection portion configured to couple to a transducer of an ultrasound probe and a scan head connection portion configured to extend from a scan head of the ultrasound probe containing the transducer. The transducer connection portion and the scan head connection portion being a single element.

Abstract: A supplementary hydrogen fuel system is described. The supplementary hydrogen fuel system can include a hydrogen generator. The hydrogen generator can include a cylindrical enclosure of metal and a fuel cell unit disposed within the cylindrical enclosure. The fuel cell unit includes an anode core coupled to a second terminal of the power source. The anode core includes indentations on one or more surfaces. The indentations are arranged according to a first pattern.

Abstract: Systems and method for cooling a hydrogen generator of a supplementary fuel system are described. A controller can monitor a power consumption metric indicative of power consumption by the hydrogen generator of the supplementary fuel system. The controller can set, in view of the monitoring of the power consumption metric, a cooling system to a first setting to cool the hydrogen generator at a first rate.

Abstract: A connector assembly for coupling an coaxial cable to an ultrasound probe includes a cable clamp having an opening extending therethrough, the opening sized to receive a coaxial cable therethrough, the coaxial cable including a strain member and a plurality of coaxial cables extending therethrough, and a collet configured to couple to the cable clamp, the collet including an arbor that is configured to tension the strain member to a predetermined tension. A method of fabricating a connector assembly and an ultrasound imaging system are also described herein.