Abstract: The present invention relates to novel antibodies that are specific for human serum albumin (HSA).

Abstract: The present invention relates to novel antibodies that are specific for human CD3, in particular for the CD3? domain.

Abstract: The present invention relates to an isolated multispecific antibody comprising a first domain specifically binding TNF? and a second domain specifically binding IL-17A and, optionally, a third domain specifically binding human serum albumin. The present invention furthermore relates to an isolated antibody which specifically binds human IL-17A, Additionally, the present invention further relates to methods of use of said antibodies, pharmaceutical compositions and methods of use thereof, and a kit comprising said antibodies. The present invention also relates to a nucleic acid comprising a nucleotide sequence encoding said antibodies, a vector comprising said nucleic acid, a host cell comprising said nucleic acid or said vector, and a method of producing said antibodies.

Abstract: The present invention relates to an isolated antibody which specifically binds human CD137, and pharmaceutical compositions and methods of use thereof. The present invention further relates to a nucleic acid comprising a nucleotide sequence encoding said antibody, a vector comprising said nucleic acid, a host cell comprising said nucleic acid or said vector, and a method of producing said antibody.

Abstract: The invention relates to a fitting for producing a metallic connection with a metal pipe, with a base body made of metal, with at least one supporting body made of metal and formed in one piece with the base body for insertion into a pipe end and with at least one pressing sleeve made of metal and connected to the base body for receiving the pipe end, the supporting body and the pressing sleeve being designed for radial pressing.

Abstract: A measuring apparatus for measuring a structure comprises at least one measurement sensor configured to measure the structure, a bearing platform configured to carry the at least one measurement sensor and a control. The control is configured to specify at least one quality reference value for at least one characteristic of measurement quality, and further configured to adjust one or more parameters of the measuring apparatus which influence the at least one characteristic of measurement quality. An actual quality value is determined and approaches the at least one quality reference value as the one or more parameters are adjusted.

Abstract: The present invention relates generally to an isolated antibody which specifically binds human CD137, and pharmaceutical compositions and methods of use thereof, a nucleic acid comprising a nucleotide sequence encoding said antibody, a vector comprising said nucleic acid, a host cell comprising said nucleic acid or said vector, and a method of producing said antibody.

Abstract: The present invention relates to novel antibodies that are specific for human serum albumin (HSA).

Abstract: The present invention relates to an isolated antibody which specifically binds human PDL 1, and pharmaceutical compositions and methods of use thereof. The present invention further relates to a nucleic acid encoding said antibody, a vector comprising said nucleic acid, a host cell comprising said nucleic acid or said vector, and a method of producing said antibody.

Abstract: The present invention relates to novel antibody variable domain combinations with advantageous properties.

Abstract: This invention relates to novel hetero-dimeric multi-specific format of multiple antibody variable domains comprising a core of two split variable domain pairs wherein both variable light domains and the two cognate variable heavy domains are positioned tandem on two separate protein chains, respectively.

Abstract: The present invention relates to novel antibodies that are specific for human CD3, in particular for the CD3? domain.

Abstract: A hydraulic cylinder includes a cylinder having axially spaced-apart first and second bores, and a piston having a piston rod and arranged in the cylinder for movement between two end positions and dividing the cylinder into a piston side and a piston-rod side. A hydraulic pump pumps hydraulic oil into the piston side to move the piston from one end position toward the other end position while hydraulic fluid is discharged from the piston-rod side via the first bore and a first outlet line. A throttling device is operably connected to the cylinder to throttle a flow of the hydraulic fluid as the piston moves past and seals the first bore so that hydraulic fluid is discharged via the second bore, thereby reducing a delivery amount of the hydraulic oil and thereby braking and damping a movement of the piston toward the other one of the end positions.

Abstract: A device designed for the three-dimensional geometrical detection of an environment includes at least one inertial measurement system for provisionally calculating a trajectory of the detection device. The device is calibrated by steps of: (a) positioning and/or orienting the detection device in a position and/or orientation with respect to at least one reference point characterized by at least one predefined relative coordinate, or determining at least one relative coordinate which characterizes the position and/or the orientation of the detection device relative to at least one reference point; (b) determining at least one error variable which characterizes the deviation of the relative coordinate in accordance with step (a) from the relative coordinate(s) provisionally calculated by the inertial measurement system; and (c) if the error variable fulfills a predefined correction criterion, correcting the provisional trajectory.

Abstract: In Prior Art, there is no System, Process, or Machinery To Receive Incoming Nuclear Weapons, Missiles or Other like Devices, or Disarm Them, or Cut Them, Relocate or Send Back To Point Of Origin. This Invention creates A System, Process, Improvement, Apparatus, Machinery To Receive Incoming Nuclear Weapons, Missiles, or Other Devices, or Expand, or Disarm, Or Cut, Sever, Rip, Tear Apart Nuclear Weapons, Missiles, Chemical or Biological Devices, Reduce Size, or Relocate Them, or Send them back to Nation Of Origin. This Antinuclear Receiving, Cutting, Disarming, Relocating System can Be Attached to Movable Vehicles, Trucks, Cars, Automobiles, Planes, Trains, Ships, Submarines, Rockets, Subways, Buses etc. To Operate on Land, Air, Sea, Space, Underwater, Underground etc. It invents An Expanding Shield that can Shelter Humans To Deter, and Protect against Nuclear Weapons. By Cutting, Disarming, Relocating Nuclear Weapons will make Nuclear Weapons Obsolete, and Save The World From Nuclear Destruction.

Abstract: A method for pulling an autonomous submersible vehicle into a mother ship. The method includes the steps of letting out a floating line from the mother ship, allowing at least part of a capturing line to rise from the submersible vehicle using a capturing buoy, to cause the submersible vehicle to cross under the floating line in such a way that the capturing line with the capturing buoy becomes caught on the floating line, and to draw the submersible vehicle to the mother ship by pulling in the floating line.

Abstract: The invention relates to an underwater work system 1 with at least one autonomous unmanned underwater vehicle 2 and one unmanned relay vehicle 4 floating at the surface of the water 3, which comprises a radio antenna 5 for external communication 26 and a drive 16. The underwater vehicle 2 is connected to the relay vehicle 4 via an internal communication device. The invention furthermore relates to a method for operating an underwater work system. In order to create an underwater work system with an autonomous underwater vehicle and an unmanned relay vehicle floating at the surface of the water as well as a method for operating such an underwater work system, which provides an increased efficiency of the autonomous underwater vehicle 2 with short mission times, it is provided according to the invention that the relay vehicle 4 is controllable by means of a control unit 16 via the at least one autonomous underwater vehicle 2 in due consideration of navigation information 17.

Abstract: A hydraulic cylinder with end position damping includes at least one cylinder in which there is arranged at least one piston which is connected to at least one piston rod and can be moved in the axial direction, wherein the cylinder is subdivided by the piston into a piston side and a rod side and the hydraulic oil necessary for actuating the piston is pumped by a hydraulic pump via inlet and outlet lines through inlet and outlet openings provided on the cylinder, wherein the cylinder is assigned a mechanical prethottling via which, during the movement of the piston, the hydraulic oil can be discharged on the rod side through a first bore until the piston, during its movement, closes the first bore and the hydraulic oil is thus discharged through a second bore, wherein, at a preset pressure, the mechanical prethrottling means forces the hydraulic pump into an electronically regulated pressure cutoff function which reduces the delivery rate of the hydraulic oil and the piston can be moved into its end position

Abstract: The invention relates to an underwater work system 1 with at least one autonomous unmanned underwater vehicle 2 and one unmanned relay vehicle 4 floating at the surface of the water 3, which comprises a radio antenna 5 for external communication 26 and a drive 16. The underwater vehicle 2 is connected to the relay vehicle 4 via an internal communication device. The invention furthermore relates to a method for operating an underwater work system. In order to create an underwater work system with an autonomous underwater vehicle and an unmanned relay vehicle floating at the surface of the water as well as a method for operating such an underwater work system, which provides an increased efficiency of the autonomous underwater vehicle 2 with short mission times, it is provided according to the invention that the relay vehicle 4 is controllable by means of a control unit 16 via the at least one autonomous underwater vehicle 2 in due consideration of navigation information 17.

Abstract: A device designed for the three-dimensional geometrical detection of an environment includes at least one inertial measurement system for provisionally calculating a trajectory of the detection device. The device is calibrated by steps of: (a) positioning and/or orienting the detection device in a position and/or orientation with respect to at least one reference point characterized by at least one predefined relative coordinate, or determining at least one relative coordinate which characterizes the position and/or the orientation of the detection device relative to at least one reference point; (b) determining at least one error variable which characterizes the deviation of the relative coordinate in accordance with step (a) from the relative coordinate(s) provisionally calculated by the inertial measurement system; and (c) if the error variable fulfills a predefined correction criterion, correcting the provisional trajectory.