Abstract: Binding proteins comprising a VL region paired with a VH region, and a CH1 region paired with a CL region, wherein the VL region and VH region comprise opposite charged mutations to facilitate pairing, and wherein the CH1 region and CL region comprise mutations to facilitate pairing, are provided. Binding proteins comprising one or more cysteine residues engineered into the VH/VL pair to form one or more disulfide bonds, are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Abstract: The system and method of the present disclosure is a contextual authentication system, comprising: an authentication server, which comprises a memory; and an authentication application, wherein said authentication application may be configured to be run on at least a primary personal computing device and one or more secondary personal computing devices. The devices are networked with each other and each other and the authentication server. The primary device may have a resource that may be shared with the secondary devices if the users of the secondary devices are able to properly provide a contextual authentication, as required by the primary device. If the secondary users cannot properly authenticate, then they are denied access. The server may make the determination.

Abstract: The system and method of the present disclosure is a contextual authentication system, comprising: an authentication server, which comprises a memory; and an authentication application, wherein said authentication application may be configured to be run on at least a primary personal computing device and one or more secondary personal computing devices. The devices are networked with each other and each other and the authentication server. The primary device may have a resource that may be shared with the secondary devices if the users of the secondary devices are able to properly provide a contextual authentication, as required by the primary device. If the secondary users cannot properly authenticate, then they are denied access. The server may make the determination.