Patents by Inventor Christian Hilty

Christian Hilty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230072083
    Abstract: The present disclosure provides methods for measuring interactions between a ligand and a protein, comprising hyperpolarizing a ligand in a solvent using para-hydrogen to form a first solution; transferring the first solution to a detector; mixing the first solution with a protein solution, the protein solution having one or more ligands of interest therein; and determining interactions of the hyperpolarized ligand with the one or more ligands of interest by observing a change in an NMR signal of the hyperpolarized ligand. The ligand can include one or more sites for hyperpolarization by parahydrogen, and one or more binding sites for interaction with the protein.
    Type: Application
    Filed: August 22, 2022
    Publication date: March 9, 2023
    Inventors: Christian HILTY, Ratnamala MANDAL, Pierce PHAM
  • Patent number: 8547095
    Abstract: A method and apparatus are described wherein a micro sample of a fluidic material may be assayed without sample contamination using NMR techniques, in combination with magnetoresistive sensors. The fluidic material to be assayed is first subject to pre-polarization, in one embodiment, by passage through a magnetic field. The magnetization of the fluidic material is then subject to an encoding process, in one embodiment an rf-induced inversion by passage through an adiabatic fast-passage module. Thereafter, the changes in magnetization are detected by a pair of solid-state magnetoresistive sensors arranged in gradiometer mode. Miniaturization is afforded by the close spacing of the various modules.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: October 1, 2013
    Assignee: The Regents of the University of California
    Inventors: Dmitry Budker, Alexander Pines, Shoujun Xu, Christian Hilty, Micah P. Ledbetter, Louis S. Bouchard
  • Publication number: 20100264917
    Abstract: A method and apparatus are described wherein a micro sample of a fluidic material may be assayed without sample contamination using NMR techniques, in combination with magnetoresistive sensors. The fluidic material to be assayed is first subject to pre-polarization, in one embodiment, by passage through a magnetic field. The magnetization of the fluidic material is then subject to an encoding process, in one embodiment an rf-induced inversion by passage through an adiabatic fast-passage module. Thereafter, the changes in magnetization are detected by a pair of solid-state magnetoresistive sensors arranged in gradiometer mode. Miniaturization is afforded by the close spacing of the various modules.
    Type: Application
    Filed: April 2, 2010
    Publication date: October 21, 2010
    Applicant: The Regents of the University of California
    Inventors: Dmitry Budker, Alexander Pines, Shoujun Xu, Christian Hilty, Micah P. Ledbetter, Louis S. Bouchard