Abstract: A computer-implemented method for generating a 2D or 3D object, including training an autoencoder on a first set of training data to identify a first set of latent variables and generate a first set of output data; training an hourglass predictor on a second set of training data, where the hourglass predictor encoder converts a set of related but different training input data to a second set of latent variables, which decode into a second set of output data of the same type as the first set of output data; and using the hourglass predictor to predict a 2D or 3D object of the same type as the first set of output data based on a 2D or 3D object of the same type as the second set of input data.

Abstract: The invention relates to an immune cell comprising at least one Fc receptor on its surface, characterised in that a hybrid molecule is grafted onto the Fc receptor, said hybrid molecule comprising at least one antibody Fc fragment covalently bound to at least one fibrin-derived peptide comprising one or more citrullyl residue(s). The present invention also relates to the uses of such a grafted cell, as well as its method of production.

Abstract: The invention relates to a hybrid molecule comprising a fibrin-derived citrullinated peptide and an antibody or antibody fragment which binds to CD38 and/or CD138, the uses of such a hybrid molecule and its method of production.

Abstract: The present invention relates to the field of therapeutic treatment, particularly of cell therapy based on CD16+ cells and NK (Natural Killer) cells. In particular, the invention relates to a pharmaceutical composition comprising a CD16+ cell, a NK cell or a NK cell precursor, in combination with a recombinant polypeptide comprising a modified Fc region, in particular a modified CH2 domain.

Abstract: A computer-implemented method for generating a 2D or 3D object, including training an autoencoder on a first set of training data to identify a first set of latent variables and generate a first set of output data; training an hourglass predictor on a second set of training data, where the hourglass predictor encoder converts a set of related but different training input data to a second set of latent variables, which decode into a second set of output data of the same type as the first set of output data; and using the hourglass predictor to predict a 2D or 3D object of the same type as the first set of output data based on a 2D or 3D object of the same type as the second set of input data.

Abstract: The present invention relates to an in vitro method for preparing a composition comprising mesenchymal stem cells (MSCs) intended for treating ischemia-reperfusion injury, comprising: a) providing MSCs; b) cultivating MSCs in a culture medium comprising a PPAR?/? agonist; c) removing the culture medium and washing the MSCs; and d) collecting MSCs in a pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier does not contain a PPAR?/? agonist. It further relates to MSCs obtained using the method of the invention, as well as their use as a medicament, preferably in the treatment or prevention of ischemia-reperfusion injury, wherein the method of treatment or prevention does not comprise administering a PPAR?/? agonist to the subject.

Abstract: A computer-implemented method for generating a 2D or 3D object, including training an autoencoder on a first set of training data to identify a first set of latent variables and generate a first set of output data; training an hourglass predictor on a second set of training data, where the hourglass predictor encoder converts a set of related but different training input data to a second set of latent variables, which decode into a second set of output data of the same type as the first set of output data; and using the hourglass predictor to predict a 2D or 3D object of the same type as the first set of output data based on a 2D or 3D object of the same type as the second set of input data.

Abstract: A computer-implemented method for generating a corresponding 3D mesh representing a 3D object includes transforming an initial three-dimensional mesh into a planar mesh, wherein each vertex or edge of the planar mesh is a transformation of a vertex or edge from the initial three-dimensional mesh; and sampling the planar mesh to generate a plurality of samples such that each sample comprises a three-dimensional coordinate representing a point in a three-dimensional space derived and/or taken directly from the initial three-dimensional mesh, and a coordinate representing a position of the sample relative to other samples; and generating the sampled matrix based on the plurality of samples; and representing the sampled matrix as a corresponding 3D mesh.

Abstract: A computer-implemented method for generating a 2D or 3D object, including training an autoencoder on a first set of training data to identify a first set of latent variables and generate a first set of output data; training an hourglass predictor on a second set of training data, where the hourglass predictor encoder converts a set of related but different training input data to a second set of latent variables, which decode into a second set of output data of the same type as the first set of output data; and using the hourglass predictor to predict a 2D or 3D object of the same type as the first set of output data based on a 2D or 3D object of the same type as the second set of input data.

Abstract: The present invention relates to peptidomimetic macrocycles comprising at least one macrocycle-forming linker and an amino acid sequence chosen from the group consisting of: i) an amino acid sequence with at least about 50%, 60%, 70%, 80%, 90%, or 95% sequence identity to a human sequence IRAK2 54-71 (SEQ ID No1) and 100% identity with the amino acids in the positions 5-6, 9-11, 14-15 or ii) an amino acid sequence with at least about 50%, 60%, 70, 80%, 90%, or 95% sequence identity to a human sequence IRAKM 66-83 (SEQ ID No2) and 100% identity with the amino acids in the positions 5-6, 9-11, 13-14, wherein the peptidomimetic macrocycle comprises an a-helix and at least two natural or two non-natural amino acids crosslinked by a macrocycle-forming linker. It also concerns method of preparation of said peptidomimetic macrocycles and uses thereof, pharmaceutical composition and uses thereof, in particular as inhibitors of inflammatory pathways.

Abstract: A computer-implemented method for generating a corresponding 3D mesh representing a 3D object includes transforming an initial three-dimensional mesh into a planar mesh, wherein each vertex or edge of the planar mesh is a transformation of a vertex or edge from the initial three-dimensional mesh; and sampling the planar mesh to generate a plurality of samples such that each sample comprises a three-dimensional coordinate representing a point in a three-dimensional space derived and/or taken directly from the initial three-dimensional mesh, and a coordinate representing a position of the sample relative to other samples; and generating the sampled matrix based on the plurality of samples; and representing the sampled matrix as a corresponding 3D mesh.

Abstract: The present invention relates to peptidomimetic macrocycles comprising at least one macrocycle-forming linker and an amino acid sequence chosen from the group consisting of: i) an amino acid sequence with at least about 50%, 60%, 70%, 80%, 90%, or 95% sequence identity to a human sequence IRAK2 54-71 (SEQ ID No 1) and 100% identity with the amino acids in the positions 5-6, 9-11, 14-15 or ii) an amino acid sequence with at least about 50%, 60%, 70, 80%, 90%, or 95% sequence identity to a human sequence IRAKM 66-83 (SEQ ID No2) and 100% identity with the amino acids in the positions 5-6, 9-11, 13-14, wherein the peptidomimetic macrocycle comprises an ?-helix and at least two natural or two non-natural amino acids crosslinked by a macrocycle-forming linker. It also concerns method of preparation of said peptidomimetic macrocycles and uses thereof, pharmaceutical composition and uses thereof, in particular as inhibitors of inflammatory pathways.

Abstract: A computer-implemented method for generating a corresponding 3D mesh representing a 3D object, includes transforming an initial three-dimensional mesh into a planar mesh, wherein each vertex or edge of the planar mesh is a transformation of a vertex or edge from the initial three-dimensional mesh; and sampling the planar mesh to generate a plurality of samples such that each sample comprises a three-dimensional coordinate representing a point in a three-dimensional space derived and/or taken directly from the initial three-dimensional mesh, and a coordinate representing a position of the sample relative to other samples; and generating the sampled matrix based on the plurality of samples; and representing the sampled matrix as a corresponding 3D mesh.

Abstract: Methods for treating an arthritic condition in a subject by administering to the subject at least one human Tr1 cell population directed to a joint-associated antigen.

Abstract: The present invention relates to the field of adeno-associated virus (AAV) based gene therapy, in particular in vivo gene therapy, of rheumatoid arthritis (RA). The invention provides recombinant AAV virions being highly efficient in delivering genes encoding therapeutic proteins to the arthritic joints, and method for using such virions in in vivo gene therapy.

Abstract: The present invention relates to methods for obtaining chondrocytes by culturing pluripotent or multipotent stem cells with a culture medium comprising Wnt6 or a derivative thereof. The inventive methods have the advantage of specifically leading to chondrogenic lineage and providing chondrocytes without differentiation towards hypertrophic chondrocytes, adipocytes or osteoblasts.

Abstract: The present invention relates to compositions comprising human Tr1 cells directed to a joint-associated antigen and methods for treating an arthritic condition.

Abstract: A computer network security system comprising a network transport device, a Domain Controller, at least one network resource and at least one client operably connected as to form a computer network wherein a means for monitoring authentication of said client to said Domain Controller is connected between said network transport device and said client.

Abstract: The present invention relates to the field of adeno-associated virus (AAV) based gene therapy, in particular in vivo gene therapy, of rheumatoid arthritis (RA). The invention provides recombinant AAV virions being highly efficient in delivering genes encoding therapeutic proteins to the arthritic joints, and method for using such virions in in vivo gene therapy.

Abstract: The technique of producing a printing on a foil in a thermal printing operation during a packaging operation in which the foil is used as a packaging foil or as an information foil sheet to be applied to or below a wrap around or packaging foil for packaging a product being an organic or inorganic product. The examples of products relevant in the present context are unlimited ranging from toys, cosmetics, consumer products, foodstuffs, drugs etc. In general, any product which is to be packed in a foil or to be applied with an information printing after the product has been included in a separate package may be relevant in the present context. High speed printing and packaging operations in which the foil on which the printing is to be applied is moved at a speed up to several hundred millimetres per second.