Abstract: The present invention relates to methods of treating a disease, and methods for reduction of the formation of anti-drug antibodies (ADAs) in response to the administration of a therapeutic agent. The invention further relates to methods of treating a disease, particularly a B-cell proliferative disorder, and methods for reduction of adverse effects in response to the administration of a therapeutic agent, particularly a T-cell activating therapeutic agent.

Abstract: The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with a CD79b antibody-drug conjugate for the treatment of cancer, especially to the combination therapy of CD20 expressing cancers with an afucosylated humanized B-Ly1 antibody and a CD79b antibody-drug conjugate.

Abstract: The present invention is directed to a combination therapy involving a type II anti-CD20 antibody and a selective Bcl-2 inhibitor for the treatment of a patient suffering from cancer, particularly, a CD20-expressing cancer.

Abstract: Techniques for providing adaptive assistive technology for assisting users with visual impairment can be used on a computing device. These techniques include displaying content to a user, capturing a series of images or video of the user using a camera, analyzing the series of images or video to determine whether the user is exhibiting behavior or characteristics indicative of visual impairment, and rendering a magnification user interface on the display configured to magnify at least a portion of the content of the display based on a determination that the user is exhibiting behavior or characteristics indicative of visual impairment. The magnification user interface may be controlled based on head and/or eye movements of the user of the computing device.

Abstract: Adaptive assistance technologies can assist a user with operating a computing device. A method according to these techniques includes analyzing user interactions with the computing device, determining that the user interactions with the computing device are indicative of a user experiencing one or more issues for which adaptive assistive technologies provided by the computing device may assist the user, identifying one or more assistive technologies provided by the computing device that may address the one or more issues, modifying one or more operating parameters of the computing device using the one or more assistive technologies, and operating the computing device according to the one or more modified operating parameters.

Abstract: The present invention generally relates to specificity assays using cell cultures, in particular to chimeric antigen receptor (CAR) expressing reporter T (CAR-T) cell assays to test novel target antigen binding moieties in different formats. Furthermore, the present invention relates to the use of reporter CAR-T cells, transfected/transduced with an engineered CAR capable of specific binding to a recognition domain comprising a tag.

Abstract: A bivalent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bivalent binding agent, and for use of the disclosed bivalent binding agent in histological staining procedures.

Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

Abstract: Techniques for application launching in a multi-display device are described. In one or more implementations, an apparatus such as a mobile device includes multiple interconnected display devices. According to one or more implementations, techniques described herein enable application launching behavior to be determined based on context information. For instance, based on a determined context condition of a multi-display client device, an application launch behavior is determined and used to launch an application on the client device.

Abstract: Technologies are disclosed herein for positioning application windows based on existing application layout and anticipated user workflows. When an existing application window and a recently launched application window are determined to be related to a workflow, and the default position of the recently launched application window is determined to overlap with the existing application window, the recently launched application window may be displayed in a non-default display region to avoid occlusion. By avoiding occlusion, the foldable device may provide a user-friendly application layout, reducing the number of times a user will move, resize, or switch between application windows in the workflow. This in turn may improve device performance and efficiency while reducing errors attributable to user input. The user-friendly layout may also enable a user to view more content at the same time, increasing productivity, reducing eye strain, facilitating operations such as cut and paste, etc.

Abstract: A bendable computing device can operate in a single display region mode when the device is in an unbent posture and can operate in a multiple display region mode when the device is in a bent posture. The multiple display region mode subdivides the bendable screen of the bendable computing device into a first display region and a second display region. When operating in the multiple display region mode, the bendable computing device can display an artificial hardware seam between the first display region and the second display region. User input gestures originating at the artificial hardware seam or terminating at the artificial hardware seam can be utilized to provide various types of functionality. Various types of functionality can also be provided when the bendable computing device detects that it has transitioned from an unbent posture to a bent posture or from a bent posture to an unbent posture.

Abstract: The present invention relates to combination therapies employing 4-1BB (CD137) agonists, in particular 4-1BBL trimer containing antigen binding molecules, in combination with HER-2 targeting agents, the use of these combination therapies for the treatment of cancer, and methods of using the combination therapies.

Abstract: A foldable computing device provides user interface (“UI”) transitions and optimizations while operating in a productivity mode. When the foldable computing device is operating in productivity mode, it can present a UI below a hardware keyboard placed over a display region and occluding only a top portion of the display region or a software keyboard presented in the display region occluding only the top portion of the display region. If the hardware keyboard or the software keyboard occlude only the bottom of the display region, a UI can be shown above the hardware keyboard or the software keyboard. The foldable computing device can adjust the position of UI windows that are occluded when the hardware or software keyboard is placed on the display region. The foldable computing device can move the UI windows back to their original positions if the hardware or software keyboard no longer occlude the display region.

Abstract: A foldable computing device can be configured to provide a user interface (UI) optimization that enables an application window to be presented in a predictable location when an application is launched, a UI optimization that enables an application window to be moved to an active display area, a UI optimization that enables a modal UI element to be presented in such a way that it does not overlap a seam on the device, a UI optimization that enables an image presented by the device to be adjusted to maintain a view of the focal point of the image across device posture or orientation changes, a UI optimization that enables the device to transition between UI modes optimized for front-facing and world-facing image capture, and/or a UI optimization that enables the device to provide a UI for instructing a user to flip the device when a biometric sensor is in use.

Abstract: The present invention relates to bispecific antibody against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2) of human IgG1 or IgG4 subclass with mutations I253A, H310A, and H435A, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

Abstract: A foldable computing device is disclosed that is configured to determine a user interface (UI) component rendering mode based on content occlusion and a prediction of user intent. The foldable computing device is configured to increase, maintain, or reduce prominence of a UI component based whether and where the UI component occludes an underlying application window or other existing UI. The foldable device may also determine an existing UI component's rendering mode based on an anticipated location of an application window associated with an application that was just launched. Furthermore, the foldable device may predict what a user is going to do with the application window, including causing any future occlusion, and adjust the UI component's rendering mode accordingly.

Abstract: A computing device implements global keyboard shortcuts targeting a specific display region using repeated key presses, targeting a specific display region using chorded modifier keys, targeting a specific display region using a single modifier key, targeting a specific display region based on user activity, targeting multiple display regions, or targeting a specific display region using multi-modal input. Other types of global keyboard shortcuts for targeting specific display regions might also be provided by other embodiments.

Abstract: A technique allows a user to project content onto a shared display region in a controlled manner. The technique involves receiving context information that describes a context in which a user is currently interacting with a local user computing device. The technique then determines, based on policy logic and the context information, whether it is appropriate to invoke a private state, or to remove the private state and enter a shared state. The private state involves presenting a privacy screen on one or more shared display regions. The local user computing device remains connected to the display device(s) that host the shared display region(s) while operating in both the private state and the shared state. According to one advantage, the technique eliminates or reduces the risk that the user will inadvertently release private information to others; further, it does so without asking the user to perform burdensome preparatory actions.

Abstract: Technologies are disclosed herein that enable a foldable computing device having multiple screen regions to perform an inter-region user interface (UI) operation in response to an intra-region UI gesture. For example, a UI gesture that begins and ends within a first region may be used to move a window from the first region to the second region. The disclosed technologies address the technical problems described above by providing succinct, accurate UI gestures that cause foldable computing devices to perform inter-region UI operations. The disclosed technologies further address the technical problems described above by combining different types of UI gestures to increase gesture accuracy and expressiveness of inter-region UI operations.