Patents by Inventor Christian Kliem

Christian Kliem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) LIGANDS COMPRISING AN AMYLASE CLEAVABLE LINKER
    Publication number: 20220324898
    Abstract: In particular, the present invention relates to a PSMA binding ligand comprising an oligosaccharide building block which comprises a bond being cleavable by alpha-amylase. Typically, this PSMA binding ligand further comprises a PSMA binding motif Q and a chelator residue A, wherein the PSMA binding motif Q and the chelator residue A are preferably linked via at least one linker LAQ comprising the oligosaccharide building block, the PSMA binding ligand thus preferably having the structure (I) A-LAQ-Q or a pharmaceutically acceptable salt or solvate thereof.
    Type: Application
    Filed: February 14, 2020
    Publication date: October 13, 2022
    Inventors: Matthias Eder, klaus Kopka, Martin Schäfer, Ulrike Bauder-Wuest, Uwe Haberkrn, Hans-Christian Kliem, Walter Mier, Thomas Lindner
  • Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
    Patent number: 10471160
    Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: November 12, 2019
    Assignees: DEUTSCHES KREBSFORSCHUNGSZENTRUM, RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
    Inventors: Matthias Eder, Klaus Kopka, Martin Schäfer, Ulrike Bauder-Wüst, Uwe Haberkorn, Michael Eisenhut, Walter Mier, Martina Benesova, Hans-Christian Kliem, Clemens Kratochwil
  • LABELED INHIBITORS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA), THEIR USE AS IMAGING AGENTS AND PHARMACEUTICAL AGENTS FOR THE TREATMENT OF PROSTATE CANCER
    Publication number: 20190008988
    Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).
    Type: Application
    Filed: July 18, 2018
    Publication date: January 10, 2019
    Inventors: Matthias EDER, Klaus KOPKA, Martin SCHÄFER, Ulrike BAUDER-WÜST, Uwe HABERKORN, Michael EISENHUT, Walter MIER, Martina BENESOVA, Hans-Christian KLIEM, Clemens KRATOCHWIL
  • Post-synthetic modification of nucleic acids by inverse diels-alder reaction
    Patent number: 9169283
    Abstract: The present invention concerns a method and a kit for the post-synthetic modification of nucleic acids via an inverse Diels-Alder reaction.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: October 27, 2015
    Assignees: DEUTSCHES KREBSFORSCHUNGSZENTRUM, RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
    Inventors: Manfred Wiessler, Peter Lorenz, Heinz Fleischhacker, Karola Ursula Fleischhacker, Marlen Fleischhacker, Nadja Fleischhacker, Christian Kliem, Andres Jäschke, Juliane Schoch
  • DIMEDON DERIVATIVE AND A METHOD FOR THE PURIFICATION OF PNA AND PEPTIDE OLIGOMERS
    Publication number: 20130274440
    Abstract: The present invention concerns a new dimedon derivative and a method for the purification of PNA and peptide oligomers.
    Type: Application
    Filed: April 8, 2013
    Publication date: October 17, 2013
    Inventors: Anette JACOB, Jörg HOHEISEL, Marc DAUBER, Manfred WIESSLER, Peter LORENZ, Heinz FLEISCHHACKER, Hans-Christian KLIEM
  • Process for the covalent coupling of two molecules by means of a diels-alder reaction with inverse electron requirement
    Patent number: 8552183
    Abstract: The present invention relates to a process for linking two molecules by means of a Diels Alder reaction with inverse electron requirement (DARinv), comprising the following steps: reaction of a (a) triazine or tetrazine with one or more electron-attracting substituents on the ring as a diene component, the electron-attracting substituents being selected from: COOR C(O)NR2 CX3 (X=halogen) halogen CN SO2—R or SO3—R PR2 wherein R?H, alkyl, aryl, heterocycle, which in turn may be substituted, where appropriate, with alkyl, OH, SH, halogen, aryl, heterocycle, nitro, carboxyamido or amine group.
    Type: Grant
    Filed: June 18, 2007
    Date of Patent: October 8, 2013
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Manfred Wiessler, Eduard Müller, Peter Lorenz, Christian Kliem, Heinz Fleischhacker
  • POST-SYNTHETIC MODIFICATION OF NUCLEIC ACIDS BY INVERSE DIELS-ALDER REACTION
    Publication number: 20130085271
    Abstract: The present invention concerns a method and a kit for the post-synthetic modification of nucleic acids via an inverse Diels-Alder reaction.
    Type: Application
    Filed: July 25, 2012
    Publication date: April 4, 2013
    Inventors: Manfred WIESSLER, Peter Lorenz, Heinz Fleischhacker, Christian Kliem, Andres Jäschke, Juliane Schoch
  • PROCESS FOR THE COVALENT COUPLING OF TWO MOLECULES BY MEANS OF A DIELS-ALDER REACTION WITH INVERSE ELECTRON REQUIREMENT
    Publication number: 20100016545
    Abstract: The present invention relates to a process for linking two molecules by means of a Diels Alder reaction with inverse electron requirement (DARinv), comprising the following steps: reaction of a (a) triazine or tetrazine with one or more electron-attracting substituents on the ring as a diene component, the electron-attracting substituents being selected from: COOR C(O)NR2 CX3 (X=halogen) halogen CN SO2—R or SO3—R PR2 wherein R?H, alkyl, aryl, heterocycle, which in turn may be substituted, where appropriate, with alkyl, OH, SH, halogen, aryl, heterocycle, nitro, carboxyamido or amine group.
    Type: Application
    Filed: June 18, 2007
    Publication date: January 21, 2010
    Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS
    Inventors: Manfred Wiessler, Eduard Müller, Peter Lorenz, Christian Kliem, Heinz Fleischhacker
  • Method for producing water-soluble saccharide conjugates and saccharide mimetics by Diels-Alder reaction
    Patent number: 6958395
    Abstract: The present invention relates to a method by which saccharide compounds can be prepared in a very easy way. This method comprises the steps of: (a) attaching at least one saccharide to a cyclic or acyclic diene, (b) reacting the saccharide-containing diene obtained in step (a) or a commercially available saccharide-containing diene with a dienophile by Diels-Alder reaction.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: October 25, 2005
    Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Manfred Wiessler, Hans-Christian Kliem, Bernd Sauerbrei, Birgit Schmauser
  • Method for producing water-soluble saccharide conjugates and saccharide mimetics by diels-alder reaction
    Publication number: 20040059101
    Abstract: The present invention relates to a method by which saccharide compounds can be prepared in a very easy way.
    Type: Application
    Filed: September 8, 2003
    Publication date: March 25, 2004
    Inventors: Manfred Weissler, Hans-Christian Kliem, Bernd Sauerbrei, Birgit Schmauser
  • SACCHARIDE LIBRARY
    Publication number: 20030119051
    Abstract: The present invention relates to a saccharide library with different saccharide-containing molecules, in which each of the molecules comprises a nuclear molecule with at least two functional groups and at least two saccharides. The invention also relates to the production of such a library and its use.
    Type: Application
    Filed: July 29, 1999
    Publication date: June 26, 2003
    Inventors: MANFRED WIESSLER, CHRISTIAN KLIEM, WALTER MIER, STEFAN MENZLER