Patents by Inventor Christian Klinger
Christian Klinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132829Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measuredType: ApplicationFiled: December 1, 2023Publication date: April 25, 2024Inventors: Detlef EISENKRAETZER, Christian KLINGER, Katrin GREPPMAIR
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Publication number: 20240124005Abstract: A control unit and a method are provided for controlling a riding function of a two-wheeled vehicle. The riding function is configured to guide the two-wheeled vehicle longitudinally and/or transversely in an automated manner. The control unit is configured to detect that the riding function is activated in order to bring about automated longitudinal and/or transverse guidance by the riding function, to determine that dynamic adaptation of the riding function is requested by the driver, and in response thereto, to initiate that, with the riding function being active, a control parameter influencing the dynamics of the riding function is adapted on the basis of the requested dynamic adaptation.Type: ApplicationFiled: February 3, 2022Publication date: April 18, 2024Inventors: Markus HAMM, Christian KLINGER, Jonas LICHTENTHAELER, Michael SCHREIBAUER
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Patent number: 11866686Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measuredType: GrantFiled: January 13, 2022Date of Patent: January 9, 2024Assignee: Hoffmann-La Roche, Inc.Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair
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Patent number: 11473042Abstract: The invention relates to a system (100) for monitoring deviations of a state of a cell culture in a bioreactor (104, 106) from a reference state of a cell culture in a reference bioreactor (102). The bioreactor comprises the same medium (M1) as the reference bioreactor.Type: GrantFiled: October 28, 2016Date of Patent: October 18, 2022Assignee: Hoffmann-La Roche, Inc.Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair, Claudia Schmidberger
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Publication number: 20220325223Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measuredType: ApplicationFiled: January 13, 2022Publication date: October 13, 2022Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair
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Patent number: 11371006Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: —receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); —receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measured aType: GrantFiled: October 28, 2016Date of Patent: June 28, 2022Assignee: Hoffman-La Roche, Inc.Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair
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Publication number: 20210040528Abstract: Herein is reported a feed mixing device for adding feed solutions with a non-physiologically pH value to a cell cultivation vessel comprising a chamber for mixing the feed solutions prior to their addition to the cell cultivation vessel as well as its use. With the feed mixing device as reported herein feed components can be provided in solution at a pH value at which they have good solubility and/or good stability whereby the pH value can be clearly different from the pH value of the cultivation medium, i.e. different from the physiological pH value. This allows performing the cultivation with more flexibility compared to a cultivation in which the pH value of the feed solution is limited to a small range around the pH value of the cultivation.Type: ApplicationFiled: October 28, 2020Publication date: February 11, 2021Applicant: Hoffmann-La Roche Inc.Inventors: Sylvia BAUMANN, Jens HOFFMANN, Alexander JOCKWER, Christian KLINGER, Thomas TROEBS
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Patent number: 10837042Abstract: Herein is reported a feed mixing device for adding feed solutions with a non-physiologically pH value to a cell cultivation vessel comprising a chamber for mixing the feed solutions prior to their addition to the cell cultivation vessel as well as its use. With the feed mixing device as reported herein feed components can be provided in solution at a pH value at which they have good solubility and/or good stability whereby the pH value can be clearly different from the pH value of the cultivation medium, i.e. different from the physiological pH value. This allows performing the cultivation with more flexibility compared to a cultivation in which the pH value of the feed solution is limited to a small range around the pH value of the cultivation.Type: GrantFiled: September 22, 2017Date of Patent: November 17, 2020Assignee: Hoffman-La Roche Inc.Inventors: Sylvia Baumann, Jens Hoffmann, Alexander Jockwer, Christian Klinger, Thomas Troebs
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Publication number: 20190367854Abstract: The invention relates to a system (100) for monitoring deviations of a state of a cell culture in a bioreactor (104, 106) from a reference state of a cell culture in a reference bioreactor (102). The bioreactor comprises the same medium (M1) as the reference bioreactor.Type: ApplicationFiled: October 28, 2016Publication date: December 5, 2019Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair, Claudia Schmidberger
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Publication number: 20180273885Abstract: The invention relates to a system (100) for monitoring deviations of a state of a cell culture in a bioreactor (104, 106) from a reference state of a cell culture in a reference bioreactor (102). The bioreactor comprises the same medium (M1) as the reference bioreactor.Type: ApplicationFiled: October 28, 2016Publication date: September 27, 2018Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair, Claudia Schmidberger
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Publication number: 20180216059Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: —receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); —receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measured aType: ApplicationFiled: October 28, 2016Publication date: August 2, 2018Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair
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Publication number: 20180010162Abstract: Herein is reported a feed mixing device for adding feed solutions with a non-physiologically pH value to a cell cultivation vessel comprising a chamber for mixing the feed solutions prior to their addition to the cell cultivation vessel as well as its use. With the feed mixing device as reported herein feed components can be provided in solution at a pH value at which they have good solubility and/or good stability whereby the pH value can be clearly different from the pH value of the cultivation medium, i.e. different from the physiological pH value. This allows performing the cultivation with more flexibility compared to a cultivation in which the pH value of the feed solution is limited to a small range around the pH value of the cultivation.Type: ApplicationFiled: September 22, 2017Publication date: January 11, 2018Applicant: Hoffmann-La Roche Inc.Inventors: Sylvia Baumann, Jens Hoffmann, Alexander Jockwer, Christian Klinger, Thomas Troebs
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Publication number: 20160208522Abstract: The invention relates to a motor vehicle lock having an actuating element, in particular a control shaft, which can be adjusted about an actuating element axis, and a drive for adjusting the actuating element, the drive having a rotor which is assigned to the actuating element and which has a permanent magnet arrangement, and a stator with a coil arrangement comprising at least two coils. It is proposed that the stator has at least two poles, via which a magnetic field which is generated by the coil arrangement is guided, and wherein, possibly in a manner which is dependent on the position of the rotor, at least one pole of the stator reaches up to an end side of the rotor apart from an axial gap in relation to the actuating element axis.Type: ApplicationFiled: August 22, 2014Publication date: July 21, 2016Inventors: Joerg Reinert, Peter Pszola, Christian Klinger, Matthias Koch
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Publication number: 20150034199Abstract: Pre-fabricated lining hose for the rehabilitation of fluid-carrying line systems comprising at least one fiber strip impregnated with a one-component epoxy resin which is curable by chain growth polymerization.Type: ApplicationFiled: February 18, 2013Publication date: February 5, 2015Inventor: Christian Klinger
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Publication number: 20140051121Abstract: Herein is reported a feed mixing device for adding feed solutions with a non-physiologically pH value to a cell cultivation vessel comprising a chamber for mixing the feed solutions prior to their addition to the cell cultivation vessel as well as its use. With the feed mixing device as reported herein feed components can be provided in solution at a pH value at which they have good solubility and/or good stability whereby the pH value can be clearly different from the pH value of the cultivation medium, i.e. different from the physiological pH value. This allows performing the cultivation with more flexibility compared to a cultivation in which the pH value of the feed solution is limited to a small range around the pH value of the cultivation.Type: ApplicationFiled: June 4, 2013Publication date: February 20, 2014Inventors: Sylvia Baumann, Jens Hoffmann, Alexander Jockwer, Christian Klinger, Thomas Troebs
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Patent number: 8460895Abstract: A method for the recombinant production of a polypeptide in a eukaryotic host cell modified in the citrate cycle is described, wherein the method comprises cultivating the eukaryotic host cell in a suitable medium under conditions which allow the expression of the polypeptide, wherein the content of dissolved CO2 (pCO2) in the medium is maintained at a constant value in the range of 10% to 20%.Type: GrantFiled: March 11, 2009Date of Patent: June 11, 2013Assignee: Hoffmann-La Roche Inc.Inventors: Detlef Eisenkraetzer, Jochen Gaetgens, Alexander Jockwer, Christian Klinger, Thomas Noll, Barbara Bezdek-Sueess
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Publication number: 20110159539Abstract: A method for the recombinant production of a polypeptide in a eukaryotic host cell modified in the citrate cycle is described, wherein the method comprises cultivating the eukaryotic host cell in a suitable medium under conditions which allow the expression of the polypeptide, wherein the content of dissolved CO2 (pCO2) in the medium is maintained at a constant value in the range of 10% to 20%.Type: ApplicationFiled: March 11, 2009Publication date: June 30, 2011Inventors: Detlef Eisenkraetzer, Alexander Jockwer, Christian Klinger, Jochen Gaetgens, Thomas Noll, Barbara Bezdek-Sueess